Trends in thyroid carcinoma among thyroidectomy patients: a 12-year multicenter study

Doubi, Aseel; Al‐Qannass, Ali; Al‐Angari, Samiah S.; Al‐Qahtani, Khalid; Alessa, Mohammed; Aldhahri, Saleh

doi:10.5144/0256-4947.2019.345

Cited by 13 publications

(10 citation statements)

References 14 publications

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“…Median age of the study population was 39.2 years. This finding is similar to studies from other Middle Eastern ethnicities ( 24 – 27 ), but lower than that seen in Western population ( 28 ). This most likely represents the inherent aggressive nature of PTC in the Middle Eastern ethnicity.…”

Section: Discussionsupporting

confidence: 88%

Male Sex Is an Independent Predictor of Recurrence-Free Survival in Middle Eastern Papillary Thyroid Carcinoma

et al. 2022

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BackgroundDisparity between sexes with regard to incidence, disease aggressiveness, and prognosis has been documented in several cancers. Although various reports have documented the association between male sex and aggressive papillary thyroid carcinoma (PTC), the prognostic impact of sex on PTC has been inconsistent. The role of sex in PTC aggressiveness and outcome in Middle Eastern PTC remains unknown. Therefore, our study retrospectively analyzed the data of a large cohort of Middle Eastern PTC patients to address this issue.MethodsWe compared men and women with respect to clinico-pathological characteristics, disease persistence, structural recurrence, risk stratification, and prognosis. We included 1,430 patients—1,085 (75.9%) women and 345 (24.1%) men.ResultsThe median follow-up was 9.3 years. At diagnosis, 27% (93/345) of men were ≥55 years, compared with 17.8% (193/1085) of women (p = 0.0003). Men had significantly more advanced disease at presentation: higher stage (p = 0.0074), larger tumor size (p = 0.0069), higher rates of lymphovascular invasion (p = 0.0129), extrathyroidal extension (p = 0.0086), regional lymph node metastasis (p = 0.0279), and distant metastasis (p = 0.0101). There was a higher rate of recurrence (p < 0.0001) and TERT mutations (p = 0.0003) in male PTC patients than in female patients. Additionally, radioiodine refractoriness was higher in male PTC patients (p = 0.0014). In multivariate analysis, male sex was an independent prognostic factor for poor recurrence-free survival (RFS) (hazard ratio = 1.58; 95% confidence interval = 1.20–2.06; p = 0.0011).ConclusionsMen with PTC are more likely to present with more advanced and aggressive disease. Importantly, male sex was an independent prognostic factor for RFS. Thus, men may benefit from more aggressive management and therapeutic interventions.

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Section: Discussionsupporting

confidence: 88%

Male Sex Is an Independent Predictor of Recurrence-Free Survival in Middle Eastern Papillary Thyroid Carcinoma

et al. 2022

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“…We are anticipating that the trend in Saudi Arabia will also exhibit a similar pattern in the upcoming few years, especially with the availability of more sophisticated medical investigations and as more Saudis gain access to private insurance. Of note, a recent Saudi study from Riyadh analysing TC trends concluded that the incidence of TC microcarcinomas has increased in the previous seven years in comparison to a steady overall TC incidence [17].…”

Section: Figure 3: Correlation Between the Year Of Diagnosis And The Tumor Size Discussionmentioning

confidence: 99%

Clinicopathological Characteristics of Thyroid Cancer in a Saudi Academic Hospital

Samargandy

Qari

ALJadani

et al. 2020

Cureus

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BackgroundThe global incidence of thyroid cancer (TC) has increased significantly over the past decades. In Saudi Arabia, it is the third most common cancer among adults. This study aims to review the clinical and histopathological characteristics of TC in Saudi Arabia and analyze the size trend over the years. MethodsWe conducted a retrospective chart review of all differentiated and poorly differentiated TC patients following up at a tertiary care center in the Western region of Saudi Arabia. All patients 11 years and older, diagnosed between 2004 -2018, and with sufficient histopathological data were included.

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“…PTC is common in Middle Eastern population with favorable long term prognosis ( 4 , 28 , 29 ). The fundamental therapy of PTC is surgery.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors for Central Lymph Node Metastases and Benefit of Prophylactic Central Lymph Node Dissection in Middle Eastern Patients With cN0 Papillary Thyroid Carcinoma

et al. 2022

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BackgroundProphylactic central lymph node dissection (PCLND) for adult patients with papillary thyroid carcinoma (PTC) is still a matter of debate. Data on incidence, risk and benefits of PCLND in Middle Eastern patients is lacking. Therefore, we aimed to identify the incidence and predictive clinico-pathological and molecular marker of PCLND in adult patients with clinically node negative (cN0) Middle Eastern PTC.MethodsThis retrospective study included 942 adult Middle Eastern patients with cN0 PTC who underwent total thyroidectomy (TT) or TT+PCLND. Clinico-pathological associations of central lymph node metastasis (CLNM) were assessed. Multivariate analysis was performed using logistic regression and Cox proportional hazards model.Results213 patients underwent PCLND and 38.0% (81/213) had positive CLNM. Multivariate analysis demonstrated age ≤55 years (Odds Ratio (OR) = 7.38; 95% Confidence Interval (CI) = 1.59 – 34.31; p = 0.0108), tumor bilaterality (OR = 3.01; 95% CI = 1.01 – 9.21; p = 0.0483), lymphovascular invasion (OR = 2.92; 95% CI = 1.18 – 7.23; p = 0.0206) and BRAF mutation (OR = 3.24; 95% CI = 1.41 – 7.49; p = 0.0058) were independent predictors of CLNM in adult PTC. Furthermore, patients who underwent PCLND showed significant association with improved recurrence-free survival (RFS; p = 0.0379). Multivariate analysis demonstrated that PCLND was an independent predictor of improved recurrence-free survival.ConclusionscN0 Middle Eastern PTC patients treated with PCLND showed a significantly better prognosis. PCLND was effective in improving RFS in Middle Eastern PTC patients and should be encouraged for patients with potential risk factors for CLNM.

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Trends in thyroid carcinoma among thyroidectomy patients: a 12-year multicenter study

Cited by 13 publications

References 14 publications

Male Sex Is an Independent Predictor of Recurrence-Free Survival in Middle Eastern Papillary Thyroid Carcinoma

Male Sex Is an Independent Predictor of Recurrence-Free Survival in Middle Eastern Papillary Thyroid Carcinoma

Clinicopathological Characteristics of Thyroid Cancer in a Saudi Academic Hospital

Risk Factors for Central Lymph Node Metastases and Benefit of Prophylactic Central Lymph Node Dissection in Middle Eastern Patients With cN0 Papillary Thyroid Carcinoma

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