Trends in the Use of Proper Methods for Estimating Mutation Rates in Fluctuation Experiments
Guillem A. Devin,
Alejandro Couce
Abstract:The accurate quantification of mutation rates holds significance across diverse fields, including evolution, cancer research, and antimicrobial resistance. Eighty years ago, Luria and Delbrück demonstrated that the proper quantification of mutation rates requires one to account for the non-linear relationship between the number of mutations and the final number of mutants in a cell population. An extensive body of literature has since emerged, offering increasingly efficient methods to account for this phenome… Show more
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