Trends in the postmortem epidemiology of invasive fungal infections at a university hospital

Lehrnbecher, Thomas; Frank, Cornelia; Engels, K.; Kriener, S.; Groll, Andreas H.; Schwabe, Dirk

doi:10.1016/j.jinf.2010.06.018

Cited by 107 publications

(79 citation statements)

References 17 publications

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“…However, exclusive kidney involvement is rare in human systemic candidiasis and kidney manifestation typically only occurs in disseminated candidiasis affecting multiple organs. 29,30 Despite this, the murine infection model enables the analysis of rapid immune activation induced by systemic Candida dissemination and has undoubtedly revealed important insights into host responses to fungal infection. 31,32 Unlike humans, mice are intrinsically Candida na€ ıve and establishing colonization of the gastrointestinal tract in adult mice requires anti-microbial therapy and oral application of Candida.…”

Section: Candida Bloodstream Infection and Sepsismentioning

confidence: 99%

Host response toCandida albicansbloodstream infection and sepsis

et al. 2015

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Section: Candida Bloodstream Infection and Sepsismentioning

confidence: 99%

Host response toCandida albicansbloodstream infection and sepsis

et al. 2015

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“…Invasive aspergillosis is associated with high morbidity and mortality (19), and in a recent case series chronic pulmonary aspergillosis was shown to have a 50% mortality rate during an 18-month period (26). It is estimated that there are over 3 million patients worldwide with allergic bronchopulmonary aspergillosis (8) and more than 1 million have chronic pulmonary aspergillosis (CPA) following tuberculosis (9).…”

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confidence: 99%

Interrogation of Related Clinical Pan-Azole-Resistant Aspergillus fumigatus Strains: G138C, Y431C, and G434C Single Nucleotide Polymorphisms in cyp51A , Upregulation of cyp51A , and Integration and Activation of Transposon Atf1 in the cyp51A Promoter

Albarrag

Anderson²,

Howard³

et al. 2011

Antimicrob Agents Chemother

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Multiple Aspergillus fumigatus isolates from a patient with two aspergillomas complicating chronic pulmonary aspergillosis were pan-azole resistant. Microsatellite typing was identical for all isolates despite major phenotypic and some growth rate differences. Three different cyp51A mutations were found (G138C, Y431C, and G434C), of which the first two were demonstrated by heterologous expression in a hypersusceptible Saccharomyces cerevisiae strain to be at least partly responsible for elevated MICs. cyp51A and cyp51B gene duplication was excluded, but increased expression of cyp51A was demonstrated in three isolates selected for additional study (7-to 13-fold increases). In the isolate with the greatest cyp51A expression, an

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“…Invasive fungal infections (IFIs) are increasing in incidence and constitute an important cause of morbidity and mortality in immunocompromised pediatric patient populations, including, but not limited to, preterm neonates, children and adolescents with hematologic malignancies, and those undergoing hematopoietic stem cell transplantation (HSCT) [1][2][3]. Although children and adults are similarly vulnerable to IFIs, important differences between these two patient groups have to be considered.…”

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confidence: 99%