Trends in the Incidence of Invasive and In Situ Vulvar Carcinoma

Judson, Patricia L.; Habermann, Elizabeth B.; Baxter, Nancy N.; Durham, Sara; Virnig, Beth A

doi:10.1097/01.aog.0000210268.57527.a1

Cited by 402 publications

(232 citation statements)

References 17 publications

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“…In Scotland the female rates were higher than the males rates throughout the period studied, whereas in our population these were initially lower than in men, but became higher from the early 1990s onwards. Judson et al (2006) found a 20% increase in invasive vulval cancer in the United States of America between 1973 and 2000. No increase was seen in the period rates for vulval cancer in our data, nor any increase in the period rates for cancers of the vagina or penis.…”

Section: Discussionmentioning

confidence: 99%

An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England

2009

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Patients diagnosed in 1960 -2004 with cancer of the cervix, anus, vulva, vagina or penis were identified from the Thames Cancer Registry database, and age-standardised period (temporal) incidence rates calculated by direct standardisation. Age-cohort modelling techniques were used to estimate age-specific incidence rates in the earlier and later cohorts, enabling the calculation of agestandardised cohort (generational) rates. Incidence of anal cancer increased for both men and women over the period studied, mainly in those born from 1940 onwards. Similar generational patterns were seen for cancers of the vulva and vagina, but those for penile cancer were different. For cervix cancer, the steep downward trend in cohort rates due to screening levelled off in women born from 1940 onwards. Our findings are compatible with the hypothesis that changes in sexual practices were a major contributor to the increases of these cancers. Programmes of vaccination against HPV, aimed at reducing the burden of cervical cancer, may also help to reduce the incidence of cancer at other anogenital sites. (Daling and Sherman, 1992;Frisch et al, 1997;Daling et al, 2004; Bjørge et al, 2002), vulva and vagina (Madeleine et al, 1997; Daling et al, 2002;Goffin et al, 2006;Madsen et al, 2008). Cancers of the anus, vulva and vagina occur more frequently than expected following cervical intraepithelial neoplasia III or invasive cervical cancer, suggesting a strong common aetiological factor (Evans et al, 2003). HPV infection may also play a role in a subset of penile squamous cell carcinomas (Iwasawa et al, 1993;Rubin et al, 2001; Daling et al, 2005;Heideman et al, 2007;Tornesello et al, 2008).Increasing trends in anal cancer have been reported, possibly due to changes in sexual practices (Daling et al, 1987;Scholefield et al, 1990;Frisch et al, 1993Frisch et al, , 1997. If this were the case, a strong generational effect would be expected in the incidence trends of anogenital cancers. We have explored this hypothesis by plotting age-standardised period (temporal) and cohort (generational) rates for cancer sites linked to HPV infection. (World Health Organization, 1976), and were retrospectively recoded to the ICD-10 classification in the case of tumours diagnosed before its introduction in the early 1990s. Examination of proportional frequency plots revealed no coding discrepancies or inconsistencies over the period of the study. Age at diagnosis was categorised into 5-year groups (0 -4, 5-9, y, 80 -84, 85 þ ), and period of diagnosis into 5-year periods (1960 -1964, 1965 -1969, y, 2000 -2004). Nominal birth cohort groups (1875, 1880, y, 2000) were then calculated by subtracting the midpoint of the age group from the midpoint of the period. For each site, an age-standardised incidence rate for each calendar period was calculated by direct standardisation, using the European standard population. As the earlier and later birth cohorts were missing data from the younger and older age groups, respectively, a Poisson regression age-cohort m...

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Section: Discussionmentioning

confidence: 99%

An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England

2009

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“…Radiation and chemotherapy treatment are usually combined with surgical treatment. Radical excision of the vulva, together with regional lymph nodes, is an operation that involves early and late complications (Judson et al, 2006). Removal of lymph nodes in which metastatic cells are present leads to a reduction in tumor mass, which can have a positive therapeutic effect.…”

Section: Introductionmentioning

confidence: 99%

Expression of Vascular Endothelial Growth Factors VEGF- C and D, VEGFR-3, and Comparison of Lymphatic Vessels Density Labeled with D2-40 Antibodies as a Prognostic Factors in Vulvar Intraepithelial Neoplasia (VIN) and Invasive Vulvar Cancer

Jach¹,

Dyduch²,

Radoń-Pokracka³

et al. 2012

Intraepithelial Neoplasia

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“…Judson and collaborators published in 2006 the biggest series of 13176 patients in USA for 74% of VIN and 26% of invasive cancers [13].…”

Section: Epidemiological Aspectmentioning

confidence: 99%

Invasive Cancer of the Vulva: Clinical and Therapeutic Aspects in the Gynecology and Obstetrics Service at Donka Hospital, Guinea- Conakry

Mk¹,

Ld²,

Diarra³

et al. 2017

Gynecol Obstet

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Results Epidemiological aspectThe frequency: The vulva cancer is rare with 12 cases among 1234 about 1%. Medium ageThe medium age during the diagnosis was 54 years with extreme of 22 and 84 years. 75% of women were olded than 55 years and menopause. The socio-economic levelThe women have low socio-economic level married women 5% housewife 67% and multiparous 75%. Clinical aspectsParity: 75% of vulva cancer was found in multiparous with a polygamy sexual regimen (Figure 1 We noted 1% of vulva cancer among the 1234 cases of Gynecological cancers diagnosed in the service. Two-third of the patients were elder than 55 years and the multiparous with 75%.The prurition and the tumefaction were the principal motive of consultation among 41.66 %.The tumor had epithelial origin in the clinical stage III in 50% of cases according to FIGO (2009). 3.6% of vulvectomy associated with lymphadenectomy in two-third and one case of radiotherapy.The cancers cases recorded were invasive epithelium type in old age women. These were intended to allow precocious diagnose and adequate taking care of the disease.

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Trends in the Incidence of Invasive and In Situ Vulvar Carcinoma

Abstract: The incidence of in situ vulvar carcinoma is increasing. The incidence of invasive vulvar cancer is also increasing but at a much lower rate.

Cited by 402 publications

References 17 publications

An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England

An analysis of temporal and generational trends in the incidence of anal and other HPV-related cancers in Southeast England

Expression of Vascular Endothelial Growth Factors VEGF- C and D, VEGFR-3, and Comparison of Lymphatic Vessels Density Labeled with D2-40 Antibodies as a Prognostic Factors in Vulvar Intraepithelial Neoplasia (VIN) and Invasive Vulvar Cancer

Invasive Cancer of the Vulva: Clinical and Therapeutic Aspects in the Gynecology and Obstetrics Service at Donka Hospital, Guinea- Conakry

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