Trends in the incidence of AIDS and epidemiological features in Tianjin, China from 2005 to 2016

Ma, Ping; Zhang, Defa; Yu, Aimin; Qiu, Chunting; Li, Lei; Yu, Fangfang; Wu, Yue; You, Wei; Guo, Yongxian; Ning, Xianjia; Lü, Wei

doi:10.18632/oncotarget.21016

Cited by 7 publications

(6 citation statements)

References 29 publications

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“…During the study period from 2011-2017, the average age of MSM decreased. The trend of decreasing age of MSM was also reported from another city in northern China, Tianjin, but no trend was found in a city in southwest China, Chengdu, and an opposite trend that was found in Beijing, the capital city of China, indicating a diversity in characteristics of MSM in different areas of China [7, 26, 27]. The education levels of MSM increased over the study period with the proportions of people with a college or above education significantly increased from 43.3% in 2011 to 70.6% in 2017 in Yinchuan.…”

Section: Discussionmentioning

confidence: 86%

“…The increasing coverage of antiretroviral therapies and scaling-up of other HIV control measures have reduced the number of new infections each year globally. However, HIV infection in MSM have been increasing or remaining high in many areas, indicating that the current control measures have not successfully reached this population, or have not correctly adapted to the changes of this population [7, 23, 24]. Therefore, monitoring of this population became extremely important to identify the risk factors that cause the high rate of new HIV infections around the world [25].…”

Section: Discussionmentioning

confidence: 99%

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Dynamic Characteristics and HIV Infection of Men who have Sex with Men from 2011 to 2017 in Yinchuan, Ningxia, China

Guan

Zhao

et al. 2019

CHR

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Objectives: Ningxia Hui Autonomous Region, an important area for ethnic Hui settlement in Northwest China, is a low HIV prevalence region. However, HIV infection rates among men who have sex with men (MSM) in Ningxia have increased to an alarming level, despite scale-up of control measures in recent years. This study aimed to understand the demographical and sexual behavior dy-namics of MSM and to explore the factors associated with HIV infection. Methods: Annual cross-sectional surveys were carried out among MSM during 2011~2017 in Yin-chuan, the capital city of Ningxia. Information regarding social demographics, sexual behavior and HIV prevention knowledge was collected. Blood samples were taken for HIV, HCV serological and genetic analysis, and syphilis serological analysis. The dynamic trend was analyzed with trend χ2 test and factors associated with HIV infection were identified by multivariate logistic regression analysis. Results: The study found a decreasing trend for mean age of the MSM population over the study peri-od. MSMs with a college education or higher increased significantly, while the proportions that were in a marriage significantly decreased over the study period. The rate of HIV positive among MSM in-creased during the study period (p<0.05), however, the rate of recently diagnosed infections decreased from 2012 (p<0.05). Overall, a very high proportion (98%) of MSM had basic knowledge of HIV prevention, however, only approximately 40% of them used condoms consistently during anal sex with male partners. Unprotected anal sex was identified as a risk factor associated with HIV infection, as was syphilis infection. Local residency status and MSM who received intervention and detection services were the factors that decreased HIV infection risk. Sequence analysis identified the HIV-1 CRF55_01B subtype from MSM for the first time in Yinchuan. Conclusion: The reduction of recent HIV diagnoses is an encouraging sign of successful HIV control measures in MSM in Ningxia. The finding that a high proportion of MSM had knowledge of HIV prevention but still conducted unprotected sex highlights the need for further control measures to change unsafe sexual practices among MSM.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Dynamic Characteristics and HIV Infection of Men who have Sex with Men from 2011 to 2017 in Yinchuan, Ningxia, China

Guan

Zhao

et al. 2019

CHR

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“…is the natural demolition rate for and is the disease related death rate from ,  is disappearance rate of the virus, 0  p represents the increase of virus level due to spreading from infected cells, 0  e is the production rate of AIDS class that is assumed to be constant in system (2). On the other hand, the second subsystem of system (1) consists of the last four equations, which represent by system (3).…”

Section: Modeling Formulationmentioning

confidence: 99%

“…It is an acute intestinal infectious disease caused by an Acquired Immunodeficiency Syndrome (AIDS) as a result of HIV infection. Statistics for the last few years show an outbreak that affected 38.8 million and caused a mortality rate of 1.2 million in 2015, with the infection rate being relatively constant at 2.6 million per year from 2006 to 2015 [2]. Mathematical modeling of viral infections has led to enhance the understanding of virus dynamics and helped in predicting and controlling the spread of viral diseases such as HIV and hepatitis A, B, and C. The first epidemiological model on HIV was studied in 1985, followed by many studies [3][4][5][6][7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Dynamical Analysis Within-Host and Between-Host for HIV\AIDS with the Application of Optimal Control Strategy

Mohsen¹,

Naji

2020

eijs

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The aims of this paper is investigating the spread of AIDS both within-host, through the contact between healthy cells with free virus inside the body, and between-host, through sexual contact among individuals and external sources of infectious. The outbreak of AIDS is described by a mathematical model consisting of two stages. The first stage describes the within-host spread of AIDS and is represented by the first three equations. While the second stage describes the between-host spread of AIDS and represented by the last four equations. The existence, uniqueness and boundedness of the solution of the model are discussed and all possible equilibrium points are determined. The local asymptotic stability (LAS) of the model is studied, while suitable Lyapunov functions are used to investigate the global asymptotic stability (GAS) of the model. Optimal control strategy is used to control the outbreak of AIDS. Finally, a numerical simulation is carried out to confirm the analytical results and understand the effects of varying the parameters on the spread of disease.

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“…The overall HIV prevalence among MSM in China increased sharply from 0.3% [3] in 2003 to 7.75% in 2016 [4]. In some Chinese cities, HIV prevalence among MSM was higher than 15% [5,6], and homosexual behaviors had become the most important route of HIV transmission [7][8][9].…”

mentioning

confidence: 99%

ART initiation and predictive factors among men who have sex with men living with HIV after the implementation of new ART strategy in China: an observational cohort study

Chen¹,

Wang

Fan³

et al. 2020

Preprint

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BackgroundChina started the new antiretroviral therapy (ART) strategy since 2016, after which free ART could be provided for all people living with HIV. We aimed to understand the prevalence of ART initiation among men who have sex with men (MSM) living with HIV and to explore how ART-related perceptions, psycho-social status etc. predict ART initiation under the new strategy.MethodsA cohort study (maximum follow-up period = 578 days) was conducted in Guangzhou, China. A total of 303 ART-naïve MSM were recruited from community. Baseline information collected demographic characteristics, HIV/AIDS-related health status, ART-related perceptions, weighting of pros versus cons and psycho-social status. The outcome was ART initiation. Cox regression models were fitted for data analyses.ResultsThe prevalence of ART initiation was 83.8% of all participants and 92.6% of MSM diagnosed recently (within 30 days). In multivariate Cox regression models, HIV-positive MSM received HIV diagnosis ≤30 days were less likely to initiate ART (HR = 0.37, 95% CI: 0.28-0.49). In adjusted analyses, belief that immediate ART initiation would have more benefit for themselves associated with increased ART initiation (HRa = 1.44, 95% CI: 1.06-1.96). In the final model, weighting of pros versus cons and time since diagnosis of HIV infection remained significant.ConclusionThe prevalence of ART initiation was high among MSM living with HIV in Guangzhou. To reach the second 90% target, measures should be focused on MSM previously diagnosed. Interventions showing HIV-positives the benefits of ART were also needed.

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Trends in the incidence of AIDS and epidemiological features in Tianjin, China from 2005 to 2016

Cited by 7 publications

References 29 publications

Dynamic Characteristics and HIV Infection of Men who have Sex with Men from 2011 to 2017 in Yinchuan, Ningxia, China

Dynamic Characteristics and HIV Infection of Men who have Sex with Men from 2011 to 2017 in Yinchuan, Ningxia, China

Dynamical Analysis Within-Host and Between-Host for HIV\AIDS with the Application of Optimal Control Strategy

ART initiation and predictive factors among men who have sex with men living with HIV after the implementation of new ART strategy in China: an observational cohort study

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