Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin

Lee, Chun-Ting; Shaw, Jei‐Fu; Chen, Jung–Ren; Kuo, Wen-Shuo; Shen, Gangxu; Grumezescu, Alexandru Mihai; Holban, Alina Maria; Wang, Yiting; Wang, Junsheng; Hsiang, Yi-Ping; Lin, Yumei; Hsu, Hsiao-Han; Yang, Chih-Hui

doi:10.3389/fphar.2020.575704

Cited by 51 publications

(33 citation statements)

References 101 publications

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“…It is a naturally derived active compound produced by Cordyceps militaris, belonging to the Clavicipitaceae family. It is a fungus with a long history of common use in traditional medicine and its specific compound, cordycepin, has several health-promoting properties, including anticancer, anti-inflammatory, immunomodulatory, antidiabetic, and antiobesity effects [85][86][87]. Furthermore, antidiabetic and nephroprotective effects have been attributed to cordycepin in experimental studies [88].…”

Section: Cordycepinmentioning

confidence: 99%

Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease

et al. 2021

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Background: The blockade of the progression or onset of pathological events is essential for the homeostasis of an organism. Some common pathological mechanisms involving a wide range of diseases are the uncontrolled inflammatory reactions that promote fibrosis, oxidative reactions, and other alterations. Natural plant compounds (NPCs) are bioactive elements obtained from natural sources that can regulate physiological processes. Inflammation is recognized as an important factor in the development and evolution of chronic renal damage. Consequently, any compound able to modulate inflammation or inflammation-related processes can be thought of as a renal protective agent and/or a potential treatment tool for controlling renal damage. The objective of this research was to review the beneficial effects of bioactive natural compounds on kidney damage to reveal their efficacy as demonstrated in clinical studies. Methods: This systematic review is based on relevant studies focused on the impact of NPCs with therapeutic potential for kidney disease treatment in humans. Results: Clinical studies have evaluated NPCs as a different way to treat or prevent renal damage and appear to show some benefits in improving OS, inflammation, and antioxidant capacity, therefore making them promising therapeutic tools to reduce or prevent the onset and progression of KD pathogenesis. Conclusions: This review shows the promising clinical properties of NPC in KD therapy. However, more robust clinical trials are needed to establish their safety and therapeutic effects in the area of renal damage.

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Section: Cordycepinmentioning

confidence: 99%

Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease

et al. 2021

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“…As a natural component of polycarbonyl and polyhydroxyl groups, emodin can coordinate and chelate with the zinc ions of type IV collagenase to inactivate type IV collagenase, thereby preventing type IV collagenase (MMP-2, MMP- 9) degradation of basement membrane and extracellular matrix of normal tissue cells, play a role in anti-invasion and anti-metastasis ( Wang, 2006 ). As a nucleoside antibiotic, cordycepin has a good application prospect in regulating immunity and scavenging free radicals ( Lee et al, 2020 ).…”

Section: Neuroprotective Role Of Other Compounds In Ischemic Brain Injurymentioning

confidence: 99%

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Xie

et al. 2021

Front. Pharmacol.

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Natural products have a significant role in the prevention of disease and boosting of health in humans and animals. Stroke is a disease with high prevalence and incidence, the pathogenesis is a complex cascade reaction. In recent years, it’s reported that a vast number of natural products have demonstrated beneficial effects on stroke worldwide. Natural products have been discovered to modulate activities with multiple targets and signaling pathways to exert neuroprotection via direct or indirect effects on enzymes, such as kinases, regulatory receptors, and proteins. This review provides a comprehensive summary of the established pharmacological effects and multiple target mechanisms of natural products for cerebral ischemic injury in vitro and in vivo preclinical models, and their potential neuro-therapeutic applications. In addition, the biological activity of natural products is closely related to their structure, and the structure-activity relationship of most natural products in neuroprotection is lacking, which should be further explored in future. Overall, we stress on natural products for their role in neuroprotection, and this wide band of pharmacological or biological activities has made them suitable candidates for the treatment of stroke.

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“…Some agents which modulate the immune response, the so-called immunomodulation agents, have been proposed for use in cancer treatment because they modulate the anti-tumor activity of immune cells either by directly stimulating immune cell function or by indirectly sensitizing cancer cells to immune cell cytotoxicity. Previously, some herbal extracts and natural bioactive compounds has been reported to have immunomodulating properties [ 15 , 16 , 17 ]. Natural substances have been increasingly receiving attention because of the remarkable potential biological activity that they exhibit, and their high levels of safety since they have been used in traditional medicine.…”

Section: Introductionmentioning

confidence: 99%

“…Cordyceps spp. has been used for centuries in Chinese medicine to promote health, and its activity to modulate the immune system has been recently reviewed emphasizing its probable utility in modern medicine [ 16 , 18 ]. Its bioactive compound, a nucleoside analogue (3′-deoxyadenosine) named cordycepin, exerts a broad range of pharmacological effects such as anti-oxidant, anti-inflammatory, anti-microbial, and anti-cancer activities [ 16 , 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…has been used for centuries in Chinese medicine to promote health, and its activity to modulate the immune system has been recently reviewed emphasizing its probable utility in modern medicine [ 16 , 18 ]. Its bioactive compound, a nucleoside analogue (3′-deoxyadenosine) named cordycepin, exerts a broad range of pharmacological effects such as anti-oxidant, anti-inflammatory, anti-microbial, and anti-cancer activities [ 16 , 19 ]. The immunomodulatory activity of cordycepin has been reported to lower lipopolysaccharide-induced RAW 264.7 macrophage inflammation via decreasing the pro-inflammatory cytokine production involving TNF–α, IL-1β, IL-6 and inflammation-related proteins iNOS, and COX2 [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

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Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells

et al. 2021

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Immunotherapy harnessing immune functions is a promising strategy for cancer treatment. Tumor sensitization is one approach to enhance tumor cell susceptibility to immune cell cytotoxicity that can be used in combination with immunotherapy to achieve therapeutic efficiency. Cordycepin, a bioactive compound that can be extracted from some Cordyceps spp. has been reported to effectively inhibit tumor growth, however, the mechanism of its tumor sensitization activity that enhances immune cell cytotoxicity is unknown. In the present study, we investigated the potency of cordycepin to sensitize a lethal cancer, cholangiocarcinoma (CCA), to natural killer (NK) cells. Treatment with cordycepin prior to and during co-culturing with NK-92 cells significantly increased cell death of KKU-213A as compared to solitary cordycepin or NK treatment. Moreover, sensitization activity was also observed in the combination of NK-92 cells and Cordyceps militaris extract that contained cordycepin as a major component. The cordycepin treatment remarkably caused an increase in TRAIL receptor (DR4 and DR5) expression in KKU-213A, suggesting the possible involvement of TRAIL signaling in KKU-213A sensitization to NK-92 cells. In conclusion, this is the first report on the sensitization activity of cordycepin on CCA cells to NK cytotoxicity, which supports that cordycepin can be further developed as an alternate immunomodulating agent.

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Trends in the Immunomodulatory Effects of Cordyceps militaris: Total Extracts, Polysaccharides and Cordycepin

Cited by 51 publications

References 101 publications

Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease

Potential Therapeutic Effects of Natural Plant Compounds in Kidney Disease

Neuroprotective Effect for Cerebral Ischemia by Natural Products: A Review

Cordycepin Sensitizes Cholangiocarcinoma Cells to Be Killed by Natural Killer-92 (NK-92) Cells

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