Trends in the identification and clinical features of celiac disease in a North American community, 1950–2001

Murray, Joseph A.; Dyke, Carol Van; Plevak, Matthew F.; Dierkhising, Ross A.; Zinsmeister, Alan R.; Melton, L. Joseph

doi:10.1053/jcgh.2003.50004

Cited by 295 publications

(237 citation statements)

References 42 publications

Supporting

Mentioning

212

Contrasting

Unclassified

Order By: Relevance

“…A significant proportion of children with CD can be detected by screening children with genetic risk, such as children with type 1 DM. Type 1 DM has been associated with diabetes mellitus,14 and a higher percentage was reported from our region 1516. It was considered the most common indication for regular screening for CD.…”

Section: Discussionmentioning

confidence: 61%

Celiac disease in children and adolescents at a singe center in Saudi Arabia

Saadah

2011

Annals of Saudi Medicine

View full text Add to dashboard Cite

BACKGROUND AND OBJECTIVES:Celiac disease (CD) is an immune-mediated enteropathy, induced by gluten in genetically susceptible individuals. The objective of this study was to describe the clinical pattern of CD in children from the western region of Saudi Arabia.DESIGN AND SETTING:Retrospective, hospital-based.PATIENTS AND METHODS:This study included children with a biopsy-proven diagnosis of CD made between September 2002 and July 2007. Children were admitted to the endoscopy unit for a small-bowel biopsy if they had gastrointestinal symptoms suggestive of CD or if they were positive for a CD-antibody screen performed for the high-risk groups.RESULTS:Eighty children were identified with a diagnosis of CD. Their mean (SD) age was 9.6 (4.9) years (range, 0.5-18 years). There were 44 (55%) female patients. Forty-one (51%) patients were detected during screening of high-risk groups, while 39 (49%) patients had classical symptoms of malabsorption. The screening also detected asymptomatic patients. Of 65 patients tested, 11 (17%) had elevated liver function tests, which reverted to normal after introduction of a gluten-free diet (GFD) except in one case. Seventy-three (91%) patients were positive for anti-tissue transglutaminase antibodies, 18 (23%), for IgG anti-gliadin antibodies; and 46 (58%), for IgA anti-gliadin antibodies. Forty-one (56%) patients showed good adherence to GFD as assessed by dietary history and the decline in anti-tTG level.CONCLUSION:CD may present with classical symptoms or be identified through screening programs. Growth and laboratory abnormalities usually improve after introduction of a GFD. Adherence to a GFD remains a problem; therefore, thorough assessment and counseling at the time of diagnosis and ongoing care are crucial.

show abstract

Section: Discussionmentioning

confidence: 61%

Celiac disease in children and adolescents at a singe center in Saudi Arabia

Saadah

2011

Annals of Saudi Medicine

View full text Add to dashboard Cite

show abstract

“…33 , 34 This suggests that changes in the interaction between environmental and genetic factors are contributing to a real disease rate increase. Some epidemiological studies have proposed that milk feeding practices and intestinal infections could play a role as predisposing factors, but to date, a causal relationship remains unconfirmed.…”

Section: Discussionmentioning

confidence: 99%

Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study

et al. 2018

View full text Add to dashboard Cite

Celiac disease (CD) is an immune-mediated enteropathy involving genetic and environmental factors, whose interaction influences disease risk. The intestinal microbiota, including viruses and bacteria, could play a role in the pathological process leading to gluten intolerance. In this study, we investigated the prevalence of pathogens in the intestinal microbiota of infants at familial risk of developing CD. We included 127 full-term newborns with at least one first-degree relative with CD. Infants were classified according to milk-feeding practice (breastfeeding or formula feeding) and HLA-DQ genotype (low, intermediate or high genetic risk). The prevalence of pathogenic bacteria and viruses was assessed in the faeces of the infants at 7 days, 1 month and 4 months of age. The prevalence of Clostridium perfringens was higher in formula-fed infants than in breast-fed over the study period, and that of C. difficile at 4 months. Among breastfed infants, a higher prevalence of enterotoxigenic E. coli (ETEC) was found in infants with the highest genetic risk compared either to those with a low or intermediate risk. Among formula-fed infants, a higher prevalence of ETEC was also found in infants with a high genetic risk compared to those of intermediate risk. Our results show that specific factors, such as formula feeding and the HLA-DQ2 genotype, previously linked to a higher risk of developing CD, influence the presence of pathogenic bacteria differently in the intestinal microbiota in early life. Further studies are warranted to establish whether these associations are related to CD onset later in life.

show abstract

“…Following approval by the Institutional Review Boards of Mayo Clinic and the Olmsted Medical Center, the complete inpatient and outpatient medical records of each candidate case were retrieved and reviewed for the diagnosis of celiac sprue between 1950 and 2002 by study criteria previously used in an epidemiologic review of celiac patients in Olmsted County [4].…”

Section: Study Samplementioning

confidence: 99%

“…The prevalence of diagnosed celiac disease varies widely from 1 per 5,000 to 2 per 300 [2,3]. Recent studies have indicated that the prevalence of diagnosed celiac disease has increased from 1 per 4,800 to 1 per 2,000 in the United States [4]. This probably still greatly underestimates the true prevalence as judged by population-based screening studies [5].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

et al. 2007

Self Cite

View full text Add to dashboard Cite

Celiac disease is associated with decreased bone density, but there are conflicting data regarding fracture risk. We determined the fracture incidence relative to matched controls in a population-based cohort with celiac disease before and after diagnosis. Olmsted County residents with celiac disease (n = 83) diagnosed between 1950 and 2002 were compared with 166 gender and age matched controls. Fracture histories were ascertained from each subject's medical records. Celiac disease is linked to an increased fracture risk before and after diagnosis. Before the index date, cases had a fracture rate twice that of controls (CI: 1.0-3.9, P = 0.045) and 2.5-fold greater after the index date (CI: 1.1-5.6, P = 0.026). Appendicular and axial fractures were 2.5 (CI: 0.9-6.5) and 3.2 times more likely (CI: 1.0-10.5) after the index date. These observations support a rationale for earlier detection of celiac disease, and active management of bone disease before bone effects have occurred, to reduce the persistent risk of fractures.

show abstract

Trends in the identification and clinical features of celiac disease in a North American community, 1950–2001

Cited by 295 publications

References 42 publications

Celiac disease in children and adolescents at a singe center in Saudi Arabia

Celiac disease in children and adolescents at a singe center in Saudi Arabia

Increased prevalence of pathogenic bacteria in the gut microbiota of infants at risk of developing celiac disease: The PROFICEL study

Long-term Fracture Risk in Patients with Celiac Disease: A Population-Based Study in Olmsted County, Minnesota

Contact Info

Product

Resources

About