Trends in the epidemiology of inflammatory bowel disease among Jewish Israeli adolescents: a population‐based study

Abstract

Background: The incidence and prevalence trends of inflammatory bowel disease (IBD) vary between developed and developing countries. Aim: To investigate the prevalence and associated sociodemographic factors of IBD in Israeli Jewish adolescents Methods: The files of the army medical corps were reviewed for adolescents recruited in 2002-2016 with confirmed IBD. Covariate data included birth date, patient and parental country of birth, number of children in the household, age at diagnosis, and socioeconomic status. Findings were compared with the remaining recruits without IBD. Results: Of the 1,144,213 adolescents recruited, 2372 (0.2%) had IBD (Crohn's disease, 68%). Median age of the cohort was 17.1 years (interquartile range, 16.9-17.3). Over the study period, the annual point prevalence per 100,000 examinees significantly increased: total IBD, 58 to 373; Crohn's disease, 42 to 425; ulcerative colitis, 16 to 128. Mean age at IBD diagnosis decreased from 15.0 ± 2.8 years in 2002-2008 to 14.3 ± 3.1 years in 2009-2016 (P < 0.0001). Significance was maintained on separate analyses of Crohn's disease and ulcerative colitis. Both diseaseswere significantly less prevalent in subjects from families with at least one parent born in a developing country and ≥3 children. There was a significant association of lower socioeconomic status with lower prevalence of Crohn's disease (odds ratio 0.41, 95% confidence interval, 0.31-0.54) and ulcerative colitis (odds ratio 0.25, 95% confidence interval, 0.15-0.42). Conclusions: The point prevalence of Crohn's disease and ulcerative colitis in IsraeliJewish adolescents increased six-fold and eight-fold, respectively, over 15 years along with a decrease in age at diagnosis.

Geographic Distribution, Phenotype and Epidemiological Tendency in Inflammatory Bowel Disease Patients in Romania

“…In pediatric patients (<17 years), 24 had IBD, among these 14/24 had UC. A similar frequency was found in studies reported in the literature [15,16,17]. In Romania, the trend of age diagnosis seems to be similar to studies reported in literature: CD was diagnosed at a younger age than UC.…”

Micronutrient Deficiencies in Children With Inflammatory Bowel Diseases

“…Inflammatory bowel disease (IBD) is a multifactorial disease characterized by chronic inflammation of the intestinal tract in genetically predisposed children and adults. IBD includes Crohn's disease (CD) and ulcerative colitis (UC), with pediatric patients currently accounting for up to 25% of newly diagnosed cases, reaching a point prevalence of 373 per 100,000 children by the age of 17 years …”

“…IBD includes Crohn's disease (CD) and ulcerative colitis (UC), with pediatric patients currently accounting for up to 25% of newly diagnosed cases, 1 reaching a point prevalence of 373 per 100,000 children by the age of 17 years. 2 Nutrition deficiencies in patients with IBD can be divided into those involving macronutrients, mainly protein intake, and micronutrients (vitamins, minerals, and trace elements). The latter can be found deficient even in the remission phase of both CD and UC.…”

Korean Children and Adolescents with Crohn's Disease Are More Likely to Present with Perianal Fistulizing Disease at Diagnosis Compared to Their European Counterparts

“…While all the investigators of the participating centers in our study were responsible for the primary examination of new patients aged <18 years, approximately one-third of the participating centers in the EUROKIDS cohort reported that new patients aged >15 years were always referred to an adult gastroenterologist [10]. Meanwhile, a recent study from Israel analyzing data from adolescents who had undergone obligatory medical examination at 17 years to assess their eligibility for military service, revealed a diagnosis age of 14.2±3.2 years among 1,612 patients who had been previously diagnosed with CD [5], which is comparable to the results of our study (median 14.7 years).…”

“…Approximately 25% of patients with CD are known to present before 20 years of age [2]. Moreover, the incidence and prevalence of pediatric CD is increasing worldwide and the age of CD diagnosis is also getting younger [3][4][5]. Meanwhile, CD is well-known as a contemporary condition of industrialized societies, and newly industrialized countries in Asia are experiencing a rapid increase in incidence [6].…”