Trends in the consumption of opioid analgesics in Spain. Higher increases as fentanyl replaces morphine

Pozo, Javier García del; Carvajal, Alfonso; Viloria, Jose Maria; Velasco, A. M.; Pozo, Victorina García del

doi:10.1007/s00228-007-0419-9

Cited by 81 publications

(48 citation statements)

References 9 publications

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“…Changes in opioid consumption have previously been described worldwide . In Europe, these were characterized by increasing use of tramadol, fentanyl and oxycodone . In Scandinavian countries, the total amount of opioids consumed increased from 2002 to 2006, due to a clear increase in fentanyl and oxycodone use, whereas the use of morphine decreased .…”

Section: Discussionmentioning

confidence: 85%

Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe

Hider‐Mlynarz

Cavalié

Maison

2018

Brit J Clinical Pharma

123

106

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Section: Discussionmentioning

confidence: 85%

Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe

Hider‐Mlynarz

Cavalié

Maison

2018

Brit J Clinical Pharma

123

106

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show abstract

“…In the past two decades, the use of opioid analgesics also significantly increased in Europe (DCAMC, 2012, Ruscitto et al, 2014, Zin et al, 2014, Schubert et al, 2013, Bandieri et al, 2009, Garcia del et al, 2008, Poulsen et al, 2013, Fredheim et al, 2010, Hawton et al, 2012, NHS, 2011,but it is unlikely that in the UK and elsewhere in Europe the non-medical use of prescription opioids will become as prevalent as in the U.S. (Fischer et al, 2014, Weisberg et al, 2014. In the U.S. opioids are widely available as they are often given by family and friends or can be obtained by "doctor shopping" or purchased from semi-legal and illegal pain clinics.…”

Section: Introductionmentioning

confidence: 99%

Ranking the harm of non-medically used prescription opioids in the UK

Amsterdam

Phillips

Henderson

et al. 2015

Regulatory Toxicology and Pharmacology

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Running head: ranking prescription opioidsKey words: opioids, MCDA, risk assessment, ranking, prescription drugs, harm,street heroin Both forms of heroin scored very high: overall harm score of 99 for injected heroin and 72 for smoked heroin on a scale of 0-100. The main feature that distinguishes both forms of street heroin use is that their harm to others is more than five times that of the other eleven opioids. The overall harm score of fentanyl (including injection of fentanyl extracted from patches) and diamorphine (medically prescribed form of heroin) was 54 and 51, respectively, whereas that of orally used opioids ranged from 32 (pethidine) to 11 (codeine-containing pharmaceuticals).Injected street heroin, fentanyl and diamorphine emerged as most harmful to users, with the latter two very low in harm to others.Pethidine, methadone, morphine and oxycodone are also low in harm to others, while moderate in harm to users.We conclude that the overall harms of non-medically used prescription opioids are less than half that of injected street heroin.These data may give a basis for precautionary regulatory measures that should be considered if the rising trend in non-medical use of prescription opioids were to become evident in the UK.

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“…Unfortunately for many pain conditions, including lower back pain (Akkaya and Ozkan 2009; Chenot et al 2007), chronic post-surgical pain (Apkarian et al 2009), neuropathic pain (Cavenagh et al 2006; Colombo et al 2006; Jensen et al 2009), and chronic pelvic pain (Dalpiaz et al 2008), there is a lack of effective treatments, although the use of opioids for treating these conditions is increasing (Atluri et al 2003; Bell et al 2009; Benyamin et al 2008; Birxner et al 2006; Garcia del Pozo et al 2008; Pergolizzi et al 2008; Stein, 2013; Trescot et al 2008). With the number of people in the United States over the age of 65 expected to more than double by 2050 (Kalapatapu and Sullivan 2010), it is expected that an increased number of aged individuals will be more frequently prescribed opioids for longer periods of time.…”

Section: Introductionmentioning

confidence: 99%

Thermal sensitivity across ages and during chronic fentanyl administration in rats

2013

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Rationale Chronic pain is becoming a more common medical diagnosis and is especially prevalent in older individuals. As such, prescribed use of opioids is on the rise, even though the efficacy for pain management in older individuals is unclear. Objectives Thus the present preclinical study assessed the effectiveness of chronic fentanyl administration to produce antinociception in aging rats (16, 20, 24 months). Methods Animals were tested in a thermal sensitivity procedure known to involve neural circuits implicated in chronic pain in humans. Sensitivity to heat and cold thermal stimulation was assessed during 28 days of fentanyl administration (1.0 mg/kg/day), and 28 days of withdrawal. Results Fentanyl resulted in decreased thermal sensitivity to heat but not cold stimulation indicated by more time spent in the hot compartment relative to time spent in the cold or neutral compartments. Unlike previous findings using a hot-water tail withdrawal procedure, tolerance did not develop to the antinociceptive effects of fentanyl over a 28-day period of drug administration. The oldest animals were least sensitive, and the youngest animals most sensitive to the locomotor-stimulating effects of fentanyl. The effect on the antinociceptive response to fentanyl in the oldest group of rats was difficult to interpret due to profound changes in the behavior of saline-treated animals. Conclusions Overall, aging modifies the behavioral effects of opioids, a finding that may inform future studies for devising appropriate treatment strategies.

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Trends in the consumption of opioid analgesics in Spain. Higher increases as fentanyl replaces morphine

Abstract: A huge increase in opioid consumption has occurred during the time period covered by this study, with fentanyl consumption accounting for most of that increase. Although oral morphine is the first-choice drug among strong opioids, fentanyl is currently the most consumed.

Cited by 81 publications

References 9 publications

Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe

Trends in analgesic consumption in France over the last 10 years and comparison of patterns across Europe

Ranking the harm of non-medically used prescription opioids in the UK

Thermal sensitivity across ages and during chronic fentanyl administration in rats

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