Trends in sinonasal cancer in The Netherlands: More squamous cell cancer, less adenocarcinoma

Clinical and histopathological presentations of sinonasal cancers in Komfo Anokye Teaching Hospital

“…A male to female ratio of 1.3:1 was in concordance to that of Betlejewski et al [7] (1.5:1), Brobby [9] (1.5:1), Fasunla and Lasisi [8] (2:1), Kuijpens et al [1] (2:1) and Arnold et al [6] (2:1). The higher incidence in males than females may be due to the fact that males may be more exposed to certain conditions that may contribute to the insurgence of the disease.…”

“…Madison Michael et al [13] reported squamous cell carcinoma (64.0%) and adenocarcinoma (18.0%), Kuijpens et al [1] also reported 46.0% and 15.0%, Myers et al [2] reported 51.0% and 11.0% while Arnold et al [6] reported 30.9% and 17.1%, respectively. All these studies confirm the higher incidence of squamous cell carcinoma in sinonasal cancers.…”

Sinonasal Adenocarcinoma—Experience of an Oncology Center

“…Intestinal type adenocarcinoma (28% -41.8%) was the second most frequent histopathology after adenocarninoma with no other specification. Twentythree patients (34.3%) had tumor extension to orbit (9), skull base (2), orbit and skull base (8) and others places like pterigopalatine fossa and cheek (5). According to T stages, 1 (1.5%) patient was T1, 19 (28.4%) T2, 21 (31.3%) T3, 21 (31.3%) T4a and 5 (7.5%) T4b.…”

“…These are mostly intestinal-type sinonasal adenocarcinomas and show a strong preference for the ethmoid sinus [4]. Some authors supported that cigarette smoking acts in a synergic manner [2,5].…”

“…They represent less than 1% of all tumours with an annual European incidence of 1 -2/100,000 inhabitants [2,3]. Furthermore, adenocarcinoma accounts for only a small percentage (10% -20%) of all sinonasal cancers [4], although it is the second most frequent histopathology type after squamous cell carcinoma [5,6]. The average age for presentation is 50 -60 years, with male predominance (2 -4:1) [4,7].…”