Trends in Second-Hand Tobacco Smoke Exposure Levels at Home among Viet Nam School Children Aged 13-15 and Associated Factors

Lam, Nguyen Tuan; Nga, Pham Thi Quynh; Minh, Hoàng Văn; Giang, Kim Bảo; Hai, Phan Thi; Huyen, Doan Thu; Linh, Nguyễn Thùy; Van, Duong Khanh; Khue, Luong Ngoc

doi:10.7314/apjcp.2016.17.s1.43

Cited by 7 publications

(4 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Children whose caregivers worked in non-governmental sectors were more likely to be exposed to passive smoking than those whose caregivers were farmers. The result was contrasted to the previous finding in a national survey on secondhand smoke exposure among Vietnamese youths, which showed that children having parents as farmers were more likely to be exposed to SHS than parents having other jobs [41]. This might be due to the small sample size in our study and the difference in the age of the studied children.…”

Section: Discussioncontrasting

confidence: 99%

Passive Smoking Exposure and Perceived Health Status in Children Seeking Pediatric Care Services at a Vietnamese Tertiary Hospital

Ngo

Phan

et al. 2020

IJERPH

View full text Add to dashboard Cite

Understanding the predictors of health conditions and exposure to secondhand smoke among children is necessary to determine the severity of the issues and identify effective solutions. Despite the significant prevalence in smoking and child exposure to secondhand smoke, there have been only a few studies focusing on this area in Vietnam, and thus the current study aims to fill in this gap. The questionnaires of 435 children aged between 0 and 6 and their caregivers, who agreed to participate in the research, were collected at the Pediatric Department of Bach Mai hospital, Hanoi, in 2016. Multivariable logistic regression was employed to identify factors associated with perceived health status and exposure to secondhand smoke among children in the last 24 h and the last 7 days from the date of the survey. Our study found that 43% of the respondents had smokers in the family, and 46.4% of children were exposed to passive smoking in the last 7 days. Urban children were most frequently exposed to passive smoking at home and in public, whereas in the rural area, the home and relatives’ houses were the most common places for exposure. Compared to children whose caregivers were farmers, children of non-government workers were more likely to be exposed to passive smoking in the last 7 days. Moreover, children in a family having smoking rules and no smokers were less likely to be exposed to passive smoking in the last 24 h and 7 days than those living in a family allowing smoking and having smokers. In conclusion, our study shows that the government needs to implement better public smoking monitoring and encourage caregivers to implement smoke-free households or smoking rules in their houses.

show abstract

Section: Discussioncontrasting

confidence: 99%

Passive Smoking Exposure and Perceived Health Status in Children Seeking Pediatric Care Services at a Vietnamese Tertiary Hospital

Ngo

Phan

et al. 2020

IJERPH

View full text Add to dashboard Cite

show abstract

“…Breast cancer (BC) is currently the most common malignancy in women, both in developed and less developed countries, and the leading cause of cancer-related deaths among women worldwide, with a high incidence rate [ 1 , 2 ]. Every breast cancer subtype is characterized by intrinsic molecular features and metastatic lesions, and their natural heterogeneity leads to a high diversity in prognosis and clinical responses to available medical treatments, even for patients with similar diagnosis, histology and stage of disease [ 3 , 4 , 5 , 6 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Human Plasma Metabolomics for Biomarker Discovery: Targeting the Molecular Subtypes in Breast Cancer

Díaz-Beltrán

González-Olmedo

Luque-Caro

et al. 2021

Cancers

View full text Add to dashboard Cite

Purpose: The aim of this study is to identify differential metabolomic signatures in plasma samples of distinct subtypes of breast cancer patients that could be used in clinical practice as diagnostic biomarkers for these molecular phenotypes and to provide a more individualized and accurate therapeutic procedure. Methods: Untargeted LC-HRMS metabolomics approach in positive and negative electrospray ionization mode was used to analyze plasma samples from LA, LB, HER2+ and TN breast cancer patients and healthy controls in order to determine specific metabolomic profiles through univariate and multivariate statistical data analysis. Results: We tentatively identified altered metabolites displaying concentration variations among the four breast cancer molecular subtypes. We found a biomarker panel of 5 candidates in LA, 7 in LB, 5 in HER2 and 3 in TN that were able to discriminate each breast cancer subtype with a false discovery range corrected p-value < 0.05 and a fold-change cutoff value > 1.3. The model clinical value was evaluated with the AUROC, providing diagnostic capacities above 0.85. Conclusion: Our study identifies metabolic profiling differences in molecular phenotypes of breast cancer. This may represent a key step towards therapy improvement in personalized medicine and prioritization of tailored therapeutic intervention strategies.

show abstract

“…Breast cancer is the most common malignant tumor in women [1]. The incidence of breast cancer among women in China is rising [2, 3]. Triple-negative breast cancer (TNBC) is a special type of breast cancer, where expressions of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor-2 (Her-2) are all negative.…”

Section: Introductionmentioning

confidence: 99%

Formononetin Enhances the Tumoricidal Effect of Everolimus in Breast Cancer MDA-MB-468 Cells by Suppressing the mTOR Pathway

Zhou

Zhang

Tian

et al. 2019

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Background. Formononetin, an active ingredient isolated from the traditional Chinese medicinal herb Astragalus membranaceus, has anticancer and chemoresistance-reducing biological activities. We evaluated the efficacy of formononetin in improving the tumoricidal effect of everolimus by suppressing the mTOR pathway in breast cancer cells. Methods. Cell survival was assessed using an MTT assay. Apoptosis was detected using flow cytometry. Proteins related to the mTOR pathway were detected and assessed using real-time PCR and Western blot analysis. Results. The results showed that formononetin enhances the efficacy of everolimus in suppressing breast cancer cell growth both in vitro and in vivo. The combination of formononetin and everolimus resulted in a 2-fold decrease in tumor volume and a 21.6% decrease in cell survival. The apoptosis ratio in cells treated with formononetin and everolimus increased by 27.9%. Formononetin and everolimus also inhibited the expression of p-mTOR and p-P70S6K and increased the expression of PTEN and p-4EBP-1. Notably, formononetin alone inhibited p-Akt expression but not everolimus. Conclusions. Formononetin enhances the tumoricidal effect of everolimus by inhibiting the activity of Akt.

show abstract

Trends in Second-Hand Tobacco Smoke Exposure Levels at Home among Viet Nam School Children Aged 13-15 and Associated Factors

Cited by 7 publications

References 5 publications

Passive Smoking Exposure and Perceived Health Status in Children Seeking Pediatric Care Services at a Vietnamese Tertiary Hospital

Passive Smoking Exposure and Perceived Health Status in Children Seeking Pediatric Care Services at a Vietnamese Tertiary Hospital

Human Plasma Metabolomics for Biomarker Discovery: Targeting the Molecular Subtypes in Breast Cancer

Formononetin Enhances the Tumoricidal Effect of Everolimus in Breast Cancer MDA-MB-468 Cells by Suppressing the mTOR Pathway

Contact Info

Product

Resources

About