Trends in sales of antidepressants in Brazil from 2014 to 2020: A time trend analysis with joinpoint regression

Hoefler, Rogério; Tiguman, Gustavo Magno Baldin; Galvão, Taís Freire; Ribeiro-Vaz, Inês; Silva, Marcus Tolentino

doi:10.1016/j.jad.2022.11.069

Cited by 3 publications

(1 citation statement)

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“…Sales of antidepressant drugs in Brazil have increased over time, mainly driven by high prescription of newer therapeutic classes. 6 , 7 Although data related to trends in drug sales are available, recent estimates on the proportion of the Brazilian population under antidepressant treatment are lacking. Investigation of the prevalence of antidepressant use in the community setting may serve as an important indicator of access to mental health care, especially in vulnerable settings.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of antidepressant use in Brazil: a systematic review with meta-analysis

Tiguman,

Hoefler,

Silva

et al. 2024

Brazilian Journal of Psychiatry

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Objectives: To estimate the prevalence of antidepressant use in Brazil. Methods: We conducted a systematic review with searches in MEDLINE, Embase, Scopus, LILACS, and SciELO up to May 2023. Two researchers independently selected studies, extracted data, and assessed the methodological quality. We pooled the prevalence of antidepressant use using meta-analyses of proportions (Freeman-Tukey transformation) and estimated heterogeneity by the I 2 statistic. OR meta-analyses of antidepressant use by sex were calculated (men as reference) and between-study variation was explored by meta-regressions. Results: Out of 3,299 records retrieved, 23 studies published in 28 reports were included, with a total of 75,061 participants. The overall prevalence of antidepressant use was 4.0% (95%CI 2.7-5.6%; I 2 = 98.5%). Use of antidepressants in the previous 3 days was higher in women (12.0%; 95%CI 9.5-15.1%; I 2 = 0%) than men (4.6%; 95%CI 3.1-6.8%; I 2 = 0%) (p < 0.001; OR = 2.82; 95%CI 1.72-4.62). Gender differences were particularly higher for antidepressant use in the previous year (women: 2.3%; 95%CI 1.6-3.1; I 2 = 37.6% vs. men: 0.5%; 95%CI 0.2-1.0%; I 2 = 0%, p < 0.001; OR = 4.18; 95%CI 2.10-8.30). Between-study variation in the overall prevalence of antidepressant use significantly increased with mean participant age (p = 0.035; residual I 2 = 0%; regression coefficient = 0.003). Conclusion: Four out of every 100 Brazilians used antidepressants in this 3-decade assessment. Use increased with age and was more prevalent in women compared to men. Registration number: PROSPERO CRD42022345332.

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Section: Introductionmentioning

confidence: 99%