Trends in Risks for Second Primary Cancers Associated With Index Human Papillomavirus–Associated Cancers

Suk, Ryan; Mahale, Parag; Sonawane, Kalyani; Sikora, Andrew G.; Chhatwal, Jagpreet; Schmeler, Kathleen M.; Sigel, Keith; Cantor, Scott B.; Chiao, Elizabeth Y.; Deshmukh, Ashish A.

doi:10.1001/jamanetworkopen.2018.1999

Cited by 56 publications

(56 citation statements)

References 46 publications

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“…Patients with HPV-related cancers are more frequently younger and with a better prognosis than those with OPSCCs HPV-negative [ 31 ]. Numerous studies in the literature show an increased risk of SPCs onset after anogenital HPV-related lesion [ 6 – 8 , 10 , 23 , 26 ]. We confirmed this evidence.…”

Section: Discussionmentioning

confidence: 99%

Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

et al. 2020

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Background The aim was to estimate the risk of subsequent extra-cervical Human Papillomavirus (HPV) related cancer in patients surgically treated for high grade cervical intraepithelial neoplasia (CIN 2–3). This is the first study in Italy investigating the occurrence of extra-cervical tumors in this cohort of patients. Methods 3184 patients surgically treated for CIN2–3 since 1992 at the Department of Surgical Sciences of University of Torino were considered. The risk of HPV-related cancer was calculated as Standardized Incidence Ratio (SIR), using as expected values tumour age specific incidence of resident population. Results 173 second primary cancer (SCPs) were identified. SIR to develop cancer after treatment for CIN2–3 was 2.2 (CI 95% 1.89–2.50). Among these occurrences, 10 are in HPV related sites: 1 anus (SIR = 1.8; 0.04–10.0), 3 vagina (SIR = 12.4; 2.56–36.3), 1 vulva (SIR = 1.7; 0.04–9.59), 5 oropharynx (SIR = 8.5; 2.76–19.8). Significant risk has been also recorded for pulmonary (SIR = 3.1; 0.70–5.27) and bladder (SIR = 4.05; 1.10–10.56), with smoking as possible cofactor. We also found increased risk for breast (SIR = 2.4; 2.07–2.84) and ovarian cancers (SIR = 2.1; 1.13–3.49), probably due to an higher adherence to spontaneous and programmed screening programs. Conclusions Our study supports the hypothesis of an increased risk of HPV-related tumours for CIN treated patients, mostly for CIN3. It is conceivable the need of early diagnosis for these cancers in this higher-risk populations.

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Section: Discussionmentioning

confidence: 99%

Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

et al. 2020

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“…We identified one additional article by manually searching the references of the included articles (Chan, Gooi, Mydlarz, & Agrawal, 2016). A total of 26 studies (Boakye et al., 2018, 2019; Chan et al., 2016; Chen et al., 2008, 2011; Chow, Au, Mang, Cheung, & Risk, 2019; Chuang et al., 2008; Cianfriglia, Di Gregorio, & Manieri, 1999; Dikshit et al., 2005; Dong & Hemminki, 2001; Goggins et al., 2010; Jégu, Binder‐Foucard, Borel, & Velten, 2013; Jung, Lim, Jung, Ryu, & Won, 2015; Lee, Wang, Lu, Huang, & Chen, 2017; Levi, Randimbison, & Te, 2003; Levi, Te, Randimbison, Maspoli, & La Vecchia, 2006; Min et al., 2019; Morris, Sikora, Hayes, Patel, & Ganly, 2011; Neumann et al., 2016; Ooft & van Ipenburg, 2016; Preyer, Concin, Obermair, Concin, & Ulmer, 2017; Scélo et al., 2007; Sikora et al., 2009; Söderholm et al., 1994; Suk et al., 2018; Warnakulasuriya et al., 2003) met the eligibility criteria for this systematic review.…”

Section: Resultsmentioning

confidence: 99%

Occurrence of metachronous second primary cancer in head and neck cancer survivors: A systematic review and meta‐analysis of the literature

et al. 2020

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“…Several previous studies have also shown a strong correlation between both cervical dysplasia and anogenital warts and the subsequent development of anal cancer. 12,13 It is possible that the reduction in cervical precancers and anogenital warts that have been reported for the past 20 years could be contributing to the observed decreasing trends of anal cancer in women. [14][15][16] After analyzing the zip-code-specific patterns of disease, we also found significant sociodemographic differences in the incidence of anal cancer.…”

Section: Discussionmentioning

confidence: 99%

Disparities in the Epidemiology of Anal Cancer: A Cross-Sectional Time Series

et al. 2020

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Purpose: To assess the trends and sociodemographic disparities of anal cancer. Methods: For this time series, billing claims were reviewed for all encounters between 2007 and 2011 in the Yale New Haven Health System. Results: There were 80 new cases identified. Decreasing trends were seen in women and increasing trend in men (À30.1% and 27.3%). Diagnoses were more common in areas with the highest proportion of racial minorities (incidence rate ratio [IRR] = 1.75; p £ 0.01) and poverty (IRR = 1.72; p = 0.04). Conclusions: Anal cancer continues to rise in men during the postvaccine era. Communities with the highest proportion of poverty and racial/ethnic minority groups bear the highest burden of disease.

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Trends in Risks for Second Primary Cancers Associated With Index Human Papillomavirus–Associated Cancers

Cited by 56 publications

References 46 publications

Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

Risk of HPV-related extra-cervical cancers in women treated for cervical intraepithelial neoplasia

Occurrence of metachronous second primary cancer in head and neck cancer survivors: A systematic review and meta‐analysis of the literature

Disparities in the Epidemiology of Anal Cancer: A Cross-Sectional Time Series

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