Background: Industrialization is the significant cause of death and inability in the most developed and developing countries, and a greater part of nourishing inadequacies and infectious diseases is attibuted to this outcome of modernity. The current study aimed at determining the status of the cardiovascular disease progression in Iran (as a developing country) by assessing the trend of risk factors such as blood pressure (PB), total cholesterol, and body mass index (BMI) from 1980 to 2010.