Trends in Renal Function After Radical Cystectomy and Ileal Conduit Diversion: New Insights Regarding Estimated Glomerular Filtration Rate Variations

Rouanne, Mathieu; Perreaud, A.; Letang, N.; Yonneau, Laurent; Hervé, Jean-Marie; Botto, Henry; Lebrét, Thierry

doi:10.1016/j.clgc.2014.11.003

Cited by 24 publications

(46 citation statements)

References 13 publications

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“…The initial eGFR in our cohort was 65.8 ml/min/1.73 m 2 , which is similar to previous reports (10,(12)(13)(14)19) with initial eGFR ranging from 65 to 69.7 ml/min, with the exception of Samuel et al, that show an eGFR of 77, most likely because of a younger population group. The eGFR after two years was 55 ml/min, again similar to previous reports with ranges from 55 to 59 (11)(12)(13)(14)19), being comparable. 62.8% of patients had a decline of their kidney function during follow up, and 32.8% of patients had a decrease of > 10 ml/min/1.73 m2 at 2 years.…”

Section: Discussionsupporting

confidence: 91%

“…The demographics of our cohort are similar to that of previous studies in terms of age, gender (10)(11)(12)(13)(14)(18)(19)(20), mean follow up period 7.5 to 10 years (5, 11-14, 19, 20), prevalence of hypertension and diabetes (10-12, 14, 19, 20), indication for RC bladder cancer (10-12, 14, 18, 19), with stages T ≥ 2 from 63 to 78% (12,19,20), therefore, our study is comparable to these previous reports.…”

Section: Discussionsupporting

confidence: 68%

“…62.8% of patients had a decline of their kidney function during follow up, and 32.8% of patients had a decrease of > 10 ml/min/1.73 m2 at 2 years. Previous studies have shown a high prevalence 70% (11,20) at 10 years, and 49% at 5 years (11), however there are reports with a lower prevalence 34 to 51% (12)(13)(14)(15). The difference in the prevalence through the different studies could be explained due to different de nitions to categorize the decline in kidney function, as well as different follow up times, and different methods to measure the GFR.…”

Section: Discussionmentioning

confidence: 97%

“…Chronic kidney disease itself is an independent risk factor for all-cause mortality, and cardiovascular events (8,9). Multiple factors have been implicated in the deterioration of renal function postoperatively, these can be divided into patient factors such as advancing age, central obesity, diabetes mellitus, hypertension and preoperative renal impairment, and iatrogenic factors such as use nephrotoxic chemotherapy, perioperative blood loss, post-operative urinary tract infection or obstruction (10)(11)(12)(13)(14)(15)(16). The trajectory of the deterioration of renal function is thought to be biphasic: an accelerated decline is seen in the rst two postoperative years with a moderate loss occurring gradually over later years (12).…”

Section: Introductionmentioning

confidence: 99%

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Long-term renal function and mortality after radical cystectomy and ileal conduit formation.

Chevarria

Ebad

Hamill

et al. 2020

Preprint

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Background. Treatment for bladder cancer includes radical cystectomy (RC) and urinary diversion, RC is associated with long-term morbidity, renal function deterioration and mortality. Our aim was to identify risk factors associated with postoperative long-term renal function decline and mortality. Methods. Retrospective study in patients with RC and urinary diversion in Beaumont Hospital from 1996 to 2016. We include patients who had assessment for at least two years post procedure and confirmed live status. We assessed the estimated glomerular filtration rate (eGFR) preoperatively, at first and second year, renal function decline > 10 ml/min/1.73 m2, start dialysis and mortality. Logistic regression analyses were applied to assess risk factors associated, a significant p-value < 0.05 was considered. Results. We included 264 patients, with median age 68.3 years, 73,7% males, main diagnose was bladder cancer 93.3%, TNM stages were grouped in T ≥ 2 75.9%, N ≥ 1 47.6% and M1 28%. The median eGFR preoperative was 65.8 ml/min/1.73 m2 and after 2 years 58.2 ml/min/1.73 m2 (p:0.009), 5.6% required chronic dialysis and 32.8% had a decrease > 10 ml/min/1.73 m2. Risk factors associated with ESKD included age (HR:1.13, CI95% 1.05–1.22), preoperative eGFR (HR:1.04, CI95% 1.01–1.07). Overall mortality was 43.2%, 75.9% at 5 and 10 years respectively, risk factors were age (HR:1.1, CI95% 1.04–1.18), preoperative eGFR (HR:1.03, CI95% 1.01–1.06) and male gender (HR:14.8, CI95% 1.1–192). Conclusions. Patients with RC have risk of progressive renal function deterioration and high mortality and the main risk factors associated were age, sex, and preoperative eGFR. Regular monitoring of renal function will permit early diagnosis and treatment.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 68%

Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

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Long-term renal function and mortality after radical cystectomy and ileal conduit formation.

Chevarria

Ebad

Hamill

et al. 2020

Preprint

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“…This rate has been reported as 26% in the first year of the follow-up and 54% in the fifth year of follow-up (2). In a study by Rouanne et al (10), these rates were reported as 39.3% and 20.3%, respectively. In our study, renal function deterioration was seen in 53.3% of patients in the first year and 41.1% of patients in the fifth year.…”

Section: Discussionmentioning

confidence: 92%

The Course of Renal Function After Radical Cystectomy with Ileal Conduit Diversion for Bladder Cancer

Özer¹,

Gören²,

Eğilmez³

et al. 2019

jus

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Amaç: Bu çalışmada mesane kanseri nedeniyle radikal sistektomi ve ileal kondüit diversiyon uygulanan hastalarda böbrek fonksiyonlarındaki değişiklik ve böbrek fonksiyon kaybı için potansiyel risk faktörleri değerlendirildi. Gereç ve Yöntem: Retrospektif çalışmada radikal sistektomi ve ileal kondüit diversiyon yapılan 114 erkek ve 7 kadın, 121 hasta değerlendirildi. Tahmini glomerüler filtrasyon hızı (eGFR) hesaplandı ve postoperatif böbrek fonksiyon değişiklikleri gözden geçirildi. Böbrek fonksiyonlarını etkileyen klinik değişkenler değerlendirildi. Bulgular: Medyan izlem süresi 35,6 ay (dağılım 12,2-139,6 ay) idi. Ortalama eGFR, ameliyat öncesi 78,37±27,58 mL/dakika/1,73 m 2 ve ameliyat sonrası 5. yılda 90,14±29,68 mL/dakika/1,73 m 2 idi. Ameliyat öncesi eGFR ile son takipteki eGFR k arşılaştırması istatistiksel olarak anlamlı bir fark göstermedi (p=1,95). İstatistiksel analiz postoperatif üriner sistem tıkanıklığı gelişiminin ve postoperatif üriner sistem enfeksiyonunun anlamlı olumsuz faktörler olduğunu gösterdi (sırası ile p=0,008, p=0,026). Sonuç: İzlem süreci boyunca, 32 hastanın (%53,3) böbrek fonksiyonlarında azalma görüldü. Postoperatif üriner sistem tıkanıklığının böbrek fonksiyonlarını etkileyen önemli bir olumsuz faktör olduğu bulundu.

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Pelvic exenteration associated with future renal dysfunction

Sando

Uehara

et al. 2020

Surg Today

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Trends in Renal Function After Radical Cystectomy and Ileal Conduit Diversion: New Insights Regarding Estimated Glomerular Filtration Rate Variations

Cited by 24 publications

References 13 publications

Long-term renal function and mortality after radical cystectomy and ileal conduit formation.

Long-term renal function and mortality after radical cystectomy and ileal conduit formation.

The Course of Renal Function After Radical Cystectomy with Ileal Conduit Diversion for Bladder Cancer

Pelvic exenteration associated with future renal dysfunction

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