Trends in primary multidrug-resistant tuberculosis in the State of Rio de Janeiro: a retrospective study conducted during 2000-2019

Bhering, Marcela; Kritski, Afrânio Lineu

doi:10.1590/0037-8682-0086-2021

Cited by 1 publication

(1 citation statement)

References 8 publications

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“…On the contrary, an upward trend of primary MDR-TB in Brazil from 2000 to 2019 was reported. [25] The possible reason for the downward trend in the current study was the implementation of effective strategies for TB control in China. Directly observed treatment short-course, which had been put forward in China since the 1990s, still plays an important role in controlling DR-TB prevalence, in terms of supervising TB patients to complete their treatments.…”

Section: Discussionmentioning

confidence: 98%

Patterns and trends of primary drug-resistant tuberculosis in Chongqing, China, from 2012 to 2020

et al. 2023

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Primary drug-resistant tuberculosis (DR-TB) contributes significantly to the global TB epidemic, particularly in countries with high TB burdens. This study aimed to investigate the characteristics of primary DR-TB prevalence in Chongqing, China, from 2012 to 2020. A total of 4546 newly diagnosed and 2769 relapse TB patients admitted to the hospital from 2012 to 2020 were included. Categorical variables were compared using Pearson chi-square test or Fisher exact test, as appropriate. Logistic regression analysis was performed to determine factors associated with primary DR-TB. The rate of primary DR-TB was 24.5%, whereas that of acquired DR-TB was 67.8%. Among newly diagnosed TB cases, the percentage of DR-TB (from 48.9 to 44.2%), monoresistant TB (from 11.8 to 9.7%), multidrug-resistant TB (MDR-TB; from 25.3 to 6.9%), and pre-extensive drug-resistant TB (from 13.7 to 5.8%) showed a decreasing trend from 2012 to 2020. Age from 15 to 64 years was a risk factor for the development of primary DR-TB (15-44 years: adjusted odds ratio = 2.227, 95% confidence interval: 1.053-4.710; 45-64 years: adjusted odds ratio = 2.223, 95% confidence interval: 1.048-4.717). The rates of primary DR-TB (P = .041) and MDR-TB (P = .007) were significantly higher in the age group of 15 to 64 years than in the age groups of ≤14 years and ≥65 years. Noticeably, rising trends of primary DR-TB (from 0 to 27.3%) and MDR-TB (from 0 to 9.1%) in the population of ≤14 years were observed from 2012 to 2020. Although the rate of primary DR-TB showed a downward trend, a rising drug-resistance rate among some particular subgroups was still observed. Further control of primary DR-TB should focus more on TB patients aged 15 to 64 years. Abbreviations: aOR = adjusted odds ratio, DR = drug-resistant, DST = drug susceptibility testing, INH = isoniazid, MDR = multidrug-resistant, MR = mono-resistant, PDR = polydrug-resistant, pre-XDR = pre-extensive drug-resistant, RFP = rifampicin, RR = rifampicin-resistant, TB = tuberculosis.

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Section: Discussionmentioning

confidence: 98%