Trends in Primary Gallbladder Cancer Incidence and Incidence-based Mortality in the United States, 1973 to 2015

Low, Soon Khai; Giannis, Dimitrios; Thuong, Nguyen Dinh; Nam, Nguyen Hai; Alshareef, Abdulmueti; Koulas, Ioannis; Geropoulos, Georgios; Moris, Demetrios; Molmenti, Ernesto P.; Huy, Nguyen Tien

doi:10.1097/coc.0000000000000918

Cited by 5 publications

(4 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…[34] In GBC patients, overall age-adjusted IBM rate increased from 2000 to 2020, but had plateaued since 2002 (APC = 0.14) compared to 2000 to 2002 (APC = 36.59*). [35] While in patients with cholangiocarcinoma (APC = 44.89*) or pancreatic cancer (APC = 27.79*), overall age-adjusted IBM rate had sheerly increased since 2002, which could partly explained by the increases in the prevalence of risk factors. [10,36] The strengths of our analysis were prominent, including the largest cohort in SEER database, long-term follow-up time and population-based settings.…”

Section: Discussionmentioning

confidence: 99%

Causes of death and nomogram for patients with oncologic hepato-biliary-pancreatic disorders: A large-cohort study

Xu,

Huang,

Yan

et al. 2024

Medicine

View full text Add to dashboard Cite

The improvement of digestive cancer survival results in increased morbidity of noncancerous comorbidities. This study aimed at clarifying causes of death (COD) and predicting overall survival (OS) in patients diagnosed with liver cancer, gallbladder cancer, cholangiocarcinoma, and pancreatic cancer. We used the Surveillance, Epidemic, and End Results database to extract information. Nomograms of multivariate Cox regression was used to predict OS of cancer patients. The models were evaluated using the concordance indexes (C-indexes), the receiver operating characteristic curves and calibration curves. Respectively 58,895, 15,324, 30,708, and 109,995 cases with cancer of liver, gallbladder, bile duct or pancreas were retrieved between 2000 and 2020. Approximately 80% deaths occurred within 1 years after cancer diagnosis. Sequence in noncancerous COD proportion was diverse, while diseases of heart always accounted for a great part. Risks of death from most noncancerous COD were significantly higher than that of the cancer-free population. Nomograms were developed by predictors of interest such as age, therapy and TNM stage. The concordance indexes of nomograms were 0.756, 0.729, 0.763, and 0.760 respectively, well-calibrating to the reality. The 0.5-, 1-, and 2-year areas under the receiver operating characteristic curve were about 0.800, indicating good reliability and accuracy. Noncancerous COD accounted for larger part in gallbladder cancer and cholangiocarcinoma. Noncancerous COD showed an upward trend as follow-up time extended and the majorities were diseases of heart, cerebrovascular disease, chronic liver disease and cirrhosis. The novel OS-nomograms can provide personalized prognosis information with satisfactory accuracy.

show abstract

Section: Discussionmentioning

confidence: 99%

Causes of death and nomogram for patients with oncologic hepato-biliary-pancreatic disorders: A large-cohort study

Xu,

Huang,

Yan

et al. 2024

Medicine

View full text Add to dashboard Cite

show abstract

“…Studies based on the Surveillance Epidemiology and End Results (SEER) database have shown a signi cant decrease in the incidence of GBC in the United States over the past 40 years, followed by a stable trend. Incidence-based mortality (IBM) has also experienced an average annual decrease of 1.69%, which may be related to advancements in surgical techniques and adjuvant and neoadjuvant therapies 7,8 . However, an increase in the incidence of GBC has been observed in the population aged < 45 years 9 .…”

Section: Introductionmentioning

confidence: 99%

Novel Multi-factor Predictive Model for Postoperative Survival in Gallbladder Cancer: A Multi-Center Study

Deng,

Xing,

et al. 2024

Preprint

View full text Add to dashboard Cite

Background and study purpose: Gallbladder cancer (GBC) is a highly aggressive malignancy, and surgery is the primary curative option. However, postoperative survival of patients with GBC remains limited. This study aimed to develop a practical model for predicting the postoperative overall survival (OS) of patients with GBC. The model aims to guide surgical decisions and benefit-risk assessments, addressing an unmet need in current practice. Methods A total of 287 patients from three medical institutions were analyzed. Univariate Cox regression analysis was used to screen for prognostic factors. Bidirectional stepwise multivariate Cox regression analysis was used for the feature selection. A nomogram was constructed to predict 1-, 3-, and 5-year postoperative survival rates. The predictive performance of the nomogram was assessed using Harrell's concordance index (C-index), receiver operating characteristic (ROC) curves, and calibration curves. Kaplan-Meier curves and log-rank tests were used to compare survival between the high-risk and low-risk groups determined by the nomogram. Decision curves were used to evaluate the clinical benefits of the nomograms. After training in one institution, internal and external validation were performed in the other two institutions to assess the reliability of the nomogram. Results Eight factors were selected via stepwise regression: TNM stage, serum carbohydrate antigen 125 (CA125), carbohydrate antigen 199 (CA199), R0 resection, body mass index (BMI), serum albumin, age-adjusted Charlson Comorbidity Index (aCCI), and serum platelet count. The C-index values were 0.770 and 0.757 before and after bootstrap resampling, respectively. The time-dependent C-index consistently exceeded 0.70 from 6 months to 5 years postoperatively, significantly outperforming TNM staging and CA199 levels. Time-dependent ROC analysis showed an area under the curve (AUC) of over 75% when predicting 1-, 3-, and 5-year postoperative survival. The calibration curves demonstrated good concordance between the predicted and observed 1-, 3-, and 5-year postoperative survival rates. The high-risk group identified by the nomogram exhibited significantly better survival than the low-risk group in both the overall population and in late-stage patients. Decision curves indicated the superior clinical benefits of the novel model compared to TNM staging and CA199 levels. The model performance in the validation process was comparable to that in the training process, demonstrating good reliability. Conclusions Our innovative multi-factor nomogram exhibits excellent discriminative and predictive efficacy, along with robust generalizability. The nomogram model has the potential to be a high-quality tool for forecasting postoperative survival in GBC, aiding clinical decision-making.

show abstract

“…Gallbladder cancer (GBC) is the most common tumor of biliary tract and the sixth most common malignant tumor of digestive system 1 .…”

Section: Introductionmentioning

confidence: 99%

Non cancer causes of death after gallbladder cancer diagnosis: a population-based analysis

Xia,

Lu,

Huo

et al. 2023

Sci Rep

View full text Add to dashboard Cite

Mortality from non cancer causes in patients with gallbladder cancer (GBC) still unclear. This study evaluated the causes and risk factors of non cancer death during different follow-up periods after GBC diagnosis. Non cancer causes of death for GBC patients diagnosed between 2000 and 2017 in Surveillance, Epidemiology and End Results database were analyzed and standardized mortality rates (SMR) for each non cancer death were calculated. Predictors for non cancer death were identified through multivariate competing risk analysis. A total 11,927 GBC patients were identified for further analysis, 9393 died during follow up. The largest proportion of non cancer deaths occurred > 3 years after diagnosis (39.4%). Most common non cancer cause were cardiovascular disease (43.3%), followed by other cause of death (34.4%) and infectious diseases (8.6%). Compared with US general population, GBC patients has higher risk of death from disease of heart (SMR, 1.58; 95%CI, 1.41–1.75), septicemia (SMR,3.21; 95%CI, 2.27–4.40), diabetes mellitus (SMR,1.97; 95%CI, 1.43–2.63), alone with other causes. Non cancer causes accounted for a significant proportion of deaths during the follow-up period after GBC diagnosis. The risk of non cancer death is higher in GBC patients than in the general population. Our study provides comprehensive assessment of death from non cancer cause in GBC patients, which has important implications for health management in GBC patients.

show abstract

Trends in Primary Gallbladder Cancer Incidence and Incidence-based Mortality in the United States, 1973 to 2015

Cited by 5 publications

References 88 publications

Causes of death and nomogram for patients with oncologic hepato-biliary-pancreatic disorders: A large-cohort study

Causes of death and nomogram for patients with oncologic hepato-biliary-pancreatic disorders: A large-cohort study

Novel Multi-factor Predictive Model for Postoperative Survival in Gallbladder Cancer: A Multi-Center Study

Non cancer causes of death after gallbladder cancer diagnosis: a population-based analysis

Contact Info

Product

Resources

About