Trends in primary, booster, and updated COVID-19 vaccine readiness in the United States, January 2021–April 2023: Implications for 2023–2024 updated COVID-19 vaccines

Ihongbe, Timothy O.; Kim, Jae-Eun C.; Dahlen, Heather; Kranzler, Elissa C.; Seserman, Kate; Moffett, Kenneth; Hoffman, Leah

doi:10.1016/j.ypmed.2024.107887

Preventive Medicine

2024

DOI: 10.1016/j.ypmed.2024.107887

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Trends in primary, booster, and updated COVID-19 vaccine readiness in the United States, January 2021–April 2023: Implications for 2023–2024 updated COVID-19 vaccines

Timothy O. Ihongbe,

Jae-Eun C. Kim,

Heather Dahlen

et al.

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2024

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Identifying the plasma metabolome responsible for mediating immune cell action in severe COVID-19: a Mendelian randomization investigation

Zhang,

Hua,

Chen

2024

Front. Cell. Infect. Microbiol.

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IntroductionThe immune response regulates the severity of COVID-19 (sCOVID-19). This study examined the cause-and-effect relationship between immune cell traits (ICTs) and the risk of severe COVID-19. Additionally, we discovered the potential role of plasma metabolome in modulating this risk.MethodsEmploying data from a genome-wide association study (GWAS), we conducted a two-sample Mendelian randomization (MR) assessment of 731 genetic ICTs and sCOVID-19 (5,101 cases, 1,383,241 controls) incidence. The MR analysis was utilized to further quantitate the degree of plasma metabolome-mediated regulation of immune traits in sCOVID-19.ResultsThe inverse variance weighted method recognized 2 plasma metabolites (PMs) responsible for casual associations between immune cells and sCOVID-19 risk. These included Tridecenedioate (C13:1-DC) which regulated the association between CD27 on IgD- CD38br (OR 0.804, 95% CI 0.699–0.925, p = 0.002) and sCOVID-19 risk (mediated proportion: 18.7%); arginine to citrulline ratio which controlled the relationship of CD39 on monocyte (OR 1.053, 95% CI 1.013–1.094, p = 0.009) with sCOVID-19 risk (mediated proportion: -7.11%). No strong evidence that genetically predicted sCOVID-19 influenced the aforementioned immune traits.ConclusionIn this study, we have successfully identified a cause-and-effect relationship between certain ICTs, PMs, and the likelihood of contracting severe COVID-19. Our findings can potentially improve the accuracy of COVID-19 prognostic evaluation and provide valuable insights into the underlying mechanisms of the disease.

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Identifying the plasma metabolome responsible for mediating immune cell action in severe COVID-19: a Mendelian randomization investigation

Zhang,

Hua,

Chen

2024

Front. Cell. Infect. Microbiol.

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show abstract

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Trends in primary, booster, and updated COVID-19 vaccine readiness in the United States, January 2021–April 2023: Implications for 2023–2024 updated COVID-19 vaccines

Cited by 1 publication

References 41 publications

Identifying the plasma metabolome responsible for mediating immune cell action in severe COVID-19: a Mendelian randomization investigation

Identifying the plasma metabolome responsible for mediating immune cell action in severe COVID-19: a Mendelian randomization investigation

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