Trends in prevalence and incidence of diabetes mellitus from 2005 to 2014 in Taiwan

Sheen, Yi‐Jing; Hsu, Chih‐Cheng; Jiang, Yi; Huang, Chien‐Ning; Liu, Jia‐Sin; Sheu, Wayne Huey‐Herng

doi:10.1016/j.jfma.2019.06.016

Cited by 113 publications

(95 citation statements)

References 14 publications

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“…Age is a major risk factor for type 2 diabetes, and the percentage of adults with diabetes increases with age. 3 The risk of impaired glucose tolerance (IGT) or type 2 diabetes rises with increasing BMI. [62][63][64] In addition, in a cohort investigation, hypertension were associated with an increased risk of developing type 2 diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…2 Type 2 diabetes, which accounts for over 90% of all patients with diabetes, may remain undiagnosed for years, leading to unchecked progress of complications because of gradual, asymptomatic onset. 3,4 Almost half of all adults with diabetes are not diagnosed globally, and the proportion of undiagnosed diabetes is as high as 30-50% even in high-income countries. 3,5 Screening for prediabetes and type 2 diabetes using an informal assessment of risk factors or validated tools in asymptomatic adults is recommended according to the available guidelines.…”

Section: Introductionmentioning

confidence: 99%

“…3,4 Almost half of all adults with diabetes are not diagnosed globally, and the proportion of undiagnosed diabetes is as high as 30-50% even in high-income countries. 3,5 Screening for prediabetes and type 2 diabetes using an informal assessment of risk factors or validated tools in asymptomatic adults is recommended according to the available guidelines. 6,7 Tumor markers are used clinically for cancer screening and monitoring.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation

Cheng

Hsu

et al. 2020

DMSO

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Purpose: Carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) are tumor-associated antigens. An increased serum level of CEA and CA19-9 separately has been reported in diabetes. In this study, we examined the composite effect of elevated serum levels of both CEA and CA19-9 on subjects with type 2 diabetes and prediabetes. Patients and Methods: A total of 3568 adults who attended a health examination were enrolled into this cross-sectional study. Subjects were grouped into four groups according to the median serum CEA and CA19-9 levels. Results: Subjects with high CEA and high CA19-9 levels had the highest proportions of diabetes (43.9%) and prediabetes (33.04%). There was a statistically significant trend in the proportion of diabetes across the four groups (P < 0.001). Multivariable logistic regression analysis revealed higher risks of type 2 diabetes in subjects with high CEA and low CA19-9 levels (odds ratio [OR] = 2.10, 95% confidence interval [CI]: 1.39-3.18, P < 0.001) and in those with high CA19-9 and low CEA levels (OR = 2.18, 95% CI: 1.42-3.34, P < 0.001) than in those with low CEA and low CA19-9 levels; among these four groups, the highest risk of type 2 diabetes was observed in subjects with high CEA and high CA19-9 levels (OR = 2.65, 95% CI: 1.81-3.88, P < 0.001). The risk of prediabetes was significantly higher only in subjects with high CEA and high CA19-9 levels compared to those with low CEA and low CA19-9 levels (OR = 1.32, 95% CI: 1.08-1.61, P = 0.006). Conclusion: CEA and CA19-9 had a synergistic ability to increase the risk of type 2 diabetes and prediabetes.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation

Cheng

Hsu

et al. 2020

DMSO

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“…Considering both the increased incidence and prolonged life expectancy, this surge in the prevalence of diabetes is expected [5, 6]. In 2014, the prevalence of diabetes in the older people (≥65 years old) in Taiwan was 39.9% and still raising [7]. It was estimated that over half of American seniors would have diabetes or prediabetes in 2030 [8], and therefore, increased numbers of people are exposed to the risk of hyperglycemic crises.…”

Section: Introductionmentioning

confidence: 99%

Risk of Dementia in Diabetic Patients with Hyperglycemic Crisis: A Nationwide Taiwanese Population-Based Cohort Study

et al. 2020

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Background: A hyperglycemic crisis episode (HCE) signifies poor control of diabetes and may increase the risk of dementia via microvascular and macrovascular injuries. Objectives: We conducted this study to clarify this issue, which remains unclear. Methods: Using the Taiwan National Health Insurance Database, we identified 9,466 diabetic patients with HCE and the identical number of diabetic patients without HCE who were matched by age and sex for this nationwide population-based cohort study. The risk of dementia was compared between the 2 cohorts by following up until 2014. Investigation of independent predictors of dementia was also done. Results: In the overall analysis, the risk of dementia between the 2 cohorts was not different. However, stratified analyses showed that patients with HCE had a higher risk of subsequent dementia in the age subgroup of 45−54 and 55–64 years (adjusted odds ratio [AOR]: 2.4, 95% confidence interval [CI]: 1.6–3.6, and AOR: 1.2, 95% CI: 1.0–1.5, respectively). In the overall analysis, older age, female sex, ≥3 HCEs, hypertension, hyperlipidemia, depression, cerebrovascular disease, Parkinson’s disease, and head injury were independent predictors. Conclusions: HCE increased the risk of dementia in diabetic patients aged 45–64 years. Dementia was predicted by ≥3 HCEs. Prevention of recurrent HCE, control of comorbidities, and close follow-up of cognitive decline and dementia are suggested in patients with HCE.

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“…The total health expenditure for adults (20–79 years) with diabetes has been growing considerably worldwide from US$ 232 billion in 2007 to US$ 760 billion in 2019, representing an increase of 328% [ 1 ]. In Taiwan, from 2005 to 2014, the total number of patients with diabetes rose by 66%, age-standardized prevalence in patients with diabetes aged 20–79 years rose by 41%, and diabetes incidence rose by 19% [ 2 ]. The average yearly costs per diabetes patient incurred at the inpatient department were 1.4 times higher than the general population, and the annual average medical cost of each diabetes patient with both micro-and macro-vascular complications was four times higher than those without such complications in Taiwan [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Social Determinants of Diabetes-Related Preventable Hospitalization in Taiwan: A Spatial Analysis

Chuang

Chen

et al. 2021

IJERPH

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Diabetes-Related Preventable Hospitalization (DRPH) has been identified as an important indicator of efficiency and quality of the health system and can be modified by social determinants. However, the spatial disparities, clustering, and relationships between DRPH and social determinants have rarely been investigated. Accordingly, this study examined the association of DRPH with area deprivation, densities of certificated diabetes health-promoting clinics (DHPC) and hospitals (DHPH), and the presence of elderly social services (ESS) using both statistical and spatial analyses. Data were obtained from the 2010–2016 National Health Insurance Research Database (NHIRD) and government open data. Township-level ordinary least squares (OSL) and geographically weighted regression (GWR) were conducted. DRPH rates were found to be negatively associated with densities of DHPC (β = −66.36, p = 0.029; 40.3% of all townships) and ESS (β = −1.85, p = 0.027; 28.4% of all townships) but positively associated with area deprivation (β = 2.96, p = 0.002; 25.6% of all townships) in both OLS and GWR models. Significant relationships were found in varying areas in the GWR model. DRPH rates are high in townships of Taiwan that have lower DHPC densities, lower ESS densities, and greater socioeconomic deprivation. Spatial analysis could identify areas of concern for potential intervention.

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Trends in prevalence and incidence of diabetes mellitus from 2005 to 2014 in Taiwan

Cited by 113 publications

References 14 publications

<p>Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation</p>

<p>Synergistic Association of Carcinoembryonic Antigen and Carbohydrate Antigen 19-9 on the Risk of Abnormal Glucose Regulation</p>

Risk of Dementia in Diabetic Patients with Hyperglycemic Crisis: A Nationwide Taiwanese Population-Based Cohort Study

Social Determinants of Diabetes-Related Preventable Hospitalization in Taiwan: A Spatial Analysis

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