Trends in Pharmacognosy: A modern science of natural medicines

Dhami, Namraj

doi:10.1016/j.hermed.2013.06.001

Cited by 49 publications

(39 citation statements)

References 53 publications

(63 reference statements)

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“…1) A considerable portion of clinical anticancer drugs in the market are natural products (NPs) or are developed from NP pharmacophores. 2,3) Monoterpenoid indole alkaloids (MIAs) are a very important family of NPs that have been well known for their anticancer activities. For example, vincristine has long been used as a first-line antitumor drug.…”

Section: Introductionmentioning

confidence: 99%

11-Methoxytabersonine Induces Necroptosis with Autophagy through AMPK/mTOR and JNK Pathways in Human Lung Cancer Cells

et al. 2020

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Aspidosperma alkaloids, a subclass of monoterpenoid indole alkaloids rich in the Apocynaceae plants, possess remarkable antitumor activities, but the underlying mechanisms have rarely been reported. In the current project, 11-methoxytabersonine (11-MT), an aspidosperma-type alkaloid isolated from Tabernaemontana bovina, significantly inhibited the viability of two human lung cancer cell lines A549 and H157, and the molecular mechanisms were thus investigated. The results showed that 11-MT killed lung cancer cells via induction of necroptosis in an apoptosis-independent manner. In addition, 11-MT strongly induced autophagy in the two cell lines, which played a protective role against 11-MT-induced necroptosis. Finally, the autophagy caused by 11-MT was found to be via activation of the AMP activated protein kinase (AMPK)/ mammalian target of rapamycin (mTOR) and the c-Jun N-terminal kinase (JNK) signaling pathways in both cells. Taken together, 11-MT exhibited an antitumor mechanism different from that of previously reported analogues and could have the potential to serve as a lead compound for the development of new chemotherapy for lung cancer.

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Section: Introductionmentioning

confidence: 99%

11-Methoxytabersonine Induces Necroptosis with Autophagy through AMPK/mTOR and JNK Pathways in Human Lung Cancer Cells

et al. 2020

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“…Since ancient times the medicinal and aromatic plants resources have been reliable source of everyday health care needs for individual and society (Gurib‐Fakim, ; Dhami, ). Even now these plants are the key ingredients for many pharmaceuticals (Gurib‐Fakim, ) and being widely traded across the industries for producing various health care and specialty materials (Lubbe & Verpoorte, ).…”

Section: Introductionmentioning

confidence: 99%

From Commodity to Brand: The Country of Origin Branding Perspective for Indian Medicinal and Aromatic plants

2018

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The medicinal and aromatic plants resources of India are known as a source of economy, sustainable livelihood, and employment for many rural communities. However, perhaps the recognition for medicinal and aromatic plants as a source for sustainable economy generation without linking sustainable marketing orientation, such as branding, is less appropriate. Because, the lack of required marketing orientation is leading challenges for resource sustainability in the sector. Therefore, to address the need of sustainable marketing orientation in the medicinal and aromatic plants sector of India and to conceptualize the branding strategy for the medicinal and aromatic plants resources, this qualitative study, based on the brand heritage of Indian medicinal and aromatic plants, demonstrates the implications of country of origin branding framework to brand the Indian medicinal and aromatic plants. Our study provides a fresh perspective on the branding of natural products and offers strategies for differentiation, competitiveness, and authenticity while trading across the globe. KEYWORDS branding strategy, country of origin, differentiation and competitiveness, marketing orientation, medicinal and aromatic plants

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“…Natural medicines have been used to enhance human and veterinary health since time immemorial and the success of modern medical science largely depends on drugs originally obtained from natural resources. In the past, traditional medicinal knowledge prevalent in the form of holy books, incantations, folklores, Materia Medica and other historical literature defined the preliminary guidelines for the authorization of plant derived natural medicines [7]. The conventional medical practices adopted for identification and authentication of natural remedies eventually framed the botanico-chemical approach to Pharmacognosy during the early 19 th century.…”

Section: Scope Of Pharmacognosymentioning

confidence: 99%

The Scope of Pharmacognosy Today & Tomorrow

Taviad¹

2018

IPCM

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Trends in Pharmacognosy: A modern science of natural medicines

Cited by 49 publications

References 53 publications

11-Methoxytabersonine Induces Necroptosis with Autophagy through AMPK/mTOR and JNK Pathways in Human Lung Cancer Cells

11-Methoxytabersonine Induces Necroptosis with Autophagy through AMPK/mTOR and JNK Pathways in Human Lung Cancer Cells

From Commodity to Brand: The Country of Origin Branding Perspective for Indian Medicinal and Aromatic plants

The Scope of Pharmacognosy Today & Tomorrow

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