Trends in peptic ulcer pharmacotherapy

Abstract

Considering the diseases of the stomach and duodenum, peptic ulcer has been the one with a significant clinical impact. The pathophysiology of peptic ulcer has centred on an imbalance between aggressive and protective factors. The discovery of Helicobacter pylori as a cause of peptic ulcer has changed our approach greatly towards this disease. Despite the decreasing frequency of H. pylori-induced peptic ulcers, peptic ulcer remains a major clinical problem partly because nonsteroidal anti-inflammatory drug (NSAID)-related ulcers and hospital admissions for ulcer complications associated with NSAIDs have increased in frequency. The interaction between H. pylori and NSAIDs is one of the most controversial issues in peptic ulcer. In this article, current concepts of peptic ulcer etiopathogenesis and the management of peptic ulcer according to the etiology were reviewed.

Perforated Peptic Ulcer Disease: A Review of History and Treatment

“…[15]. In recent years, Helicobacter pylori infection and NSAIDs have been identified as the two main causes of peptic ulcer [17]. The use of crack cocaine has also led to an increase in PPU, but with a different underlying mechanism, since PPU secondary to the use of crack cocaine is caused by ischemia of the gastric mucosa, and treatment of these perforations does not require acid reducing definitive surgery [12].…”

“…Duodenal ulcer is the predominant lesion of the western population, whereas gastric ulcers are more frequent in oriental countries, particularly in Japan. Gastric ulcers have a higher associated mortality and a greater morbidity resulting from hemorrhage, perforation and obstruction [17]. PPU used to be a disorder mainly of younger patients (predominantly males), but recently the age of PPU patients is increasing (predominantly females) [16,20].…”

Perforated Peptic Ulcer: A Clinical Analysis and Outcome

“…5 found the perforation to be more common in men deducing it to be on the basis of greater hardship, alcoholism and NSAIDs. Helicobacter pylori infection is responsible for more than 90% of duodenal ulcers and up to 80% of gastric ulcers, Sivri (2004). 6 Ahmed (2005).…”

“…Helicobacter pylori infection is responsible for more than 90% of duodenal ulcers and up to 80% of gastric ulcers, Sivri (2004). 6 Ahmed (2005). 7 In recent times helicobacter pylori infection and NSAIDs are said to be the two main causes of peptic ulcer, Sivri (2004).…”

“…6 Ahmed (2005). 7 In recent times helicobacter pylori infection and NSAIDs are said to be the two main causes of peptic ulcer, Sivri (2004). 6 Helicobacter pylori test was not done in our study because of lack of test materials.…”