Trends in Pediatric Thyroid Cancer Incidence, Treatment, and Clinical Course in Korea During 2004–2016: A Nationwide Population-Based Study

Lee, Young Ah; Yun, Hyo Ri; Lee, Jun-Young; Moon, Hyemi; Shin, Choong Ho; Kim, Sin Gon; Park, Young Joo

doi:10.1089/thy.2020.0155

Cited by 16 publications

(24 citation statements)

References 33 publications

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“…Pediatric thyroid cancer can be differentiated from adult thyroid cancer based on some characteristics, such as a high frequency of ETE, increased multifocality and bilaterality, a high incidence of nodal involvement, a higher risk of recurrence, and an excellent prognosis [2,3]. The ATA guidelines recommend aggressive surgery (subtotal or BTT) for the treatment of pediatric thyroid cancer.…”

Section: Discussionmentioning

confidence: 99%

“…However, the incidence of thyroid cancer in children has rapidly continued to increase in the last three decades. Thyroid cancer in advanced stages with local or distant metastasis at the time of diagnosis and recurrence is more common in children than in adults, but the prognosis remains very favorable [1][2][3][4][5][6]. The important clinical, molecular, and pathological differences Cancers 2021, 13, 3293. https://doi.org/10.3390/cancers13133293 https://www.mdpi.com/journal/cancers in differentiated thyroid cancer among children compared to that in adults have prompted the development of unique pediatric guidelines.…”

Section: Introductionmentioning

confidence: 99%

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Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

Lee

Kim

et al. 2021

Cancers

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Thyroid cancer in children is very uncommon. For pediatric thyroid cancer, robotic surgery has served as a minimally invasive surgical alternative to conventional open surgery. Our study aimed to evaluate the results of robotic versus open surgical treatment for patients with thyroid cancer younger than 20 years of age at the time of diagnosis. This retrospective review included 161 pediatric patients who underwent robotic transaxillary or conventional open thyroidectomy at our institution from 2008 to 2019. Of these patients, 99 comprised the robotic group and 62 the open group. Patient demographics, surgical outcomes, and disease-free survival rates were compared between the two groups. Patients in the open group were more likely to have advanced stage diseases with a larger tumor size and higher tumor-node-metastasis stage than those in the robotic group. Operation time and follow-up period were similar in both groups. Patients in the robotic group had a lower rate of postoperative complications and a shorter length of hospital stay, but they also had a lower average number of retrieved central lymph nodes. However, there were no significant between group differences in recurrence rates and disease-free survival. In the hands of an experienced surgeon, robotic thyroidectomy is a feasible and safe option for pediatric patients.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

Lee

Kim

et al. 2021

Cancers

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“…Differentiated thyroid cancer (DTC) is the most common paediatric endocrine cancer and accounts for 3% of all paediatric cases of malignant neoplasms 1‐4 . Although disease‐specific survival rate exceeds 99% at 30 years in paediatric DTC, 4,5 cancer recurrence and persistence remain a concern for paediatric patients, their parents and physicians.…”

Section: Introductionmentioning

confidence: 99%

Prognostic value of lymph node ratio in children and adolescents with papillary thyroid cancer

Wang

Zhang

et al. 2021

Clinical Endocrinology

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Objective Neck lymph node (LN) metastasis is a common feature of paediatric papillary thyroid cancer, and LN ratio (LNR) is defined as the ratio of the number of positive LNs excised to the total number of removed. Unlike in adults, few data are available regarding the clinical implication of LNR in the paediatric population. Our purpose was to investigate the association of LNR with clinical outcomes in paediatric papillary thyroid cancer. Design & Methods The study retrospectively reviewed 136 consecutive children and adolescents with papillary thyroid cancer and LN involvement but no initial distant metastasis. Initial treatment, included in all patients a total thyroidectomy with central and/or lateral neck dissection followed by radioactive iodine ablation. Within the neck dissections, total number of LNs removed, total positive LNs and LN ratios were determined. The effect of clinicopathologic characteristics and intraoperative findings on persistent and recurrent diseases were analysed by univariate and multivariate analyses. Results Median number of positive LNs was 9, and median LNR was 0.4. During a median follow‐up of 49 months (range, 12.0‐139 months), persistent disease occurred in 43 (31.6%) patients. The multivariable analysis showed that age and LNR were the independent factors predictive of persistent disease. Patients with a LNR >0.34 exhibited a threefold higher risk of persistent disease after initial therapy than the counterparts (P = .02). Conclusion Our findings suggest that LNR was an independent determinant predictive of persistent disease after initial therapy in children and adolescents with papillary thyroid cancer.

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“…The increasing temporal trends in TC incidence in adults was also found for PATC by Vaccarella et al who suggested that overdiagnosis could have a major role in children and adolescents as well as in adults [33]. While in a number of countries a significantly increasing IR of PATC has been documented [4,15,30,[34][35][36], this is not a universal finding [34,37]. It also remains unclear whether any apparent rises are due to increased detection or true increase of PATC (at least in some populations).…”

Section: Introductionmentioning

confidence: 60%

Increasing incidence and survival of paediatric and adolescent thyroid cancer in Cyprus 1998–2017: A population-based study from the Cyprus Pediatric Oncology Registry

Loizou

Demetriou

Erdmann

et al. 2021

Cancer Epidemiology

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Trends in Pediatric Thyroid Cancer Incidence, Treatment, and Clinical Course in Korea During 2004–2016: A Nationwide Population-Based Study

Cited by 16 publications

References 33 publications

Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

Comparison of Surgical Outcomes between Robotic Transaxillary and Conventional Open Thyroidectomy in Pediatric Thyroid Cancer

Prognostic value of lymph node ratio in children and adolescents with papillary thyroid cancer

Increasing incidence and survival of paediatric and adolescent thyroid cancer in Cyprus 1998–2017: A population-based study from the Cyprus Pediatric Oncology Registry

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