Trends in mouth cancer incidence in Mumbai, India (1995⿿2009): An age-period-cohort analysis

Shridhar, Krithiga; Rajaraman, Preetha; Koyande, Shravani; Parikh, Purvish; Chaturvedi, Pankaj; Dhillon, Preet K.; Dikshit, Rajesh

doi:10.1016/j.canep.2016.03.007

Cited by 14 publications

(5 citation statements)

References 21 publications

(32 reference statements)

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“…According to NCRP data from Mumbai, the incidence of mouth cancer increased sharply in men from 1999 to 2009 (3.3% annually), while it increased somewhat in women from 2002 to 2009. [ 39 ] The world’s highest incidence rates of oral cancer have been found in South Asian nations like Bangladesh, India, Pakistan, Sri Lanka, and Taiwan. These countries’ chewing practices of tobacco and betel nut combined with a lack of knowledge and access to health care.…”

Section: Discussionmentioning

confidence: 99%

Occurrence and Distribution of Cancers with Emphasis Upon Oral Cancers in Registered Oncology Institutes of South India – A Retrospective Study

Asmin,

Nusrath,

Divakar

2024

Indian Journal of Community Medicine

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Background: In the past two decades, the growing economy associated with changes in lifestyle-related behavior is partially responsible for the increasing cancer burden in India. To assess the occurrence and distribution of oral cancer based on the analysis of hospital records from registered oncology institutes of South India over a period of three years. Materials and Methods: A multicenter, retrospective study was conducted at seven major hospitals in South India to assess the incidence and distribution of cancer among patients over a period of three years (2016–2018). Data were collected on a custom-made validated proforma. Analysis was done using R commander software. Results: A total of 156090 various types of cancers were reported to the included institutes over a three-year period, an almost similar gender distribution was observed, males (n = 78806, 42.99% per lakh) compared to their female counterparts (n = 77284, 42.16% per lakh). Among males’ lung cancer was the most common type with 17709 cases (9.65% per lakh) and among females, breast cancer was the leading cancer type with 22855 total cases (12.46% per lakh). Over a period of three years, a total of 21084 records of malignancies pertaining to oral cavity were identified accounting for 13.51% of cases. Among oral cancers, tongue was the most common site to be involved accounting for 44.22% (2016–2018) cases followed by buccal mucosa (14.69%), least common site to be involved was lip which accounted for 3.49% of the total oral cancer cases. Conclusion: Breast cancer was the most common cancer followed by lung cancer. Oral cancers occupied second among males and fifth rank in the order of occurrence among females. Tongue was the most common site followed by buccal mucosa. The least common site affected by oral cancer was the lip.

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Section: Discussionmentioning

confidence: 99%

Occurrence and Distribution of Cancers with Emphasis Upon Oral Cancers in Registered Oncology Institutes of South India – A Retrospective Study

Asmin,

Nusrath,

Divakar

2024

Indian Journal of Community Medicine

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“…[ 13 ] A report analyzing the Mumbai Cancer Registry found that the rates of oral cancer have been steadily rising over 15 years, from 1995 to 2009, at the rate of 2.7% annually. [ 14 ] A study from South India reported the overall incidence of HNSCC to have been decreasing over 10 years from 1986 to 98, however, a trend toward rising incidence of oral tongue cancers was noted. [ 15 ]…”

Section: Discussionmentioning

confidence: 99%

Human papillomavirus in head and neck cancer in India: Current status and consensus recommendations

Murthy

Calcuttawala

Chadha

et al. 2017

South Asian J Cancer

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Human papillomavirus (HPV) associated head and neck squamous cell cancers (HNSCC) have become increasingly common in the West, but the same cannot be said about India. These cancers have a different biology and confer a better prognosis, however, its current role in the management of patients in India is not clearly defined. At the 35th Indian Cooperative Oncology Network conference held in September 2016, a panel of radiation, surgical and medical oncologists, pathologists, and basic scientists from across the country having experience in clinical research with respect to HPV in HNSCC reviewed the available literature from India. All the ideas and facts were thereafter collated in this report. Various topics of controversy in dealing with the diagnosis and management of HPV-associated HNSCC have been highlighted in this report in context to the Indian scenario. Furthermore, the prevalence of the same and its association with tobacco and high-risk sexual behavior has been touched on. Conclusively, a set of recommendations has been proposed by the panel to guide the practicing oncologists of the country while dealing with HPV-associated HNSCC.

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“…Oral cancer is a malignant tumor that occurs in tissues and organs within the oral cavity and usually originates from cells in the oral cavity and can spread to lymph nodes in the neck, other tissues and organs in the head and neck, and even other parts of the body [ 1 , 2 ]. The age of onset of oral cancer is mainly in the range of 40–70 years, and incidence of oral cancer is higher in developed countries, as well as in parts of Asia and Africa [ 3 ]. Oral cancer can occur at various sites within the oral cavity, such as the lip, tongue, and oral mucosa, and has many types, is aggressive, is easy to recur, and early symptoms will be slight pain, discomfort, ulceration, and so on, which can be easily overlooked or misdiagnosed [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

CEACAM1 as a molecular target in oral cancer

Ma,

Wang,

et al. 2023

Aging

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Objective: The majority of oral cancer is caused by malignant transformation of squamous cells in surface of the oral mucosa. However, the relationship between CEACAM1 and oral cancer is unclear. Methods: GSE23558 and GSE25099 profiles were downloaded from gene expression omnibus (GEO). Differentially expressed genes (DEGs) were screened and weighted gene co-expression network analysis (WGCNA) was performed. Construction and analysis of protein-protein interaction (PPI) Network. Gene Ontology (GO) and Kyoto Encyclopedia of Gene and Genome (KEGG), gene set enrichment analysis (GSEA), gene expression heatmap, immune infiltration analysis, comparative toxicogenomics database (CTD) were performed. TargetScan screened miRNAs that regulated central DEGs. Western blotting (WB) experiment was performed. Results: 1269 DEGs were identified. According to GO analysis, they were mainly enriched in same protein binding, signal receptor binding, cell surface, epithelial cell development. KEGG analysis showed that they were mainly enriched in cancer pathways, PI3K Akt signaling pathway, TNF signaling pathway, NF kappa B signaling pathway, TGF beta signaling pathway. PPI network showed that 11 genes (CDCA8, CCNA2, MELK, KIF2C, CDC45, HMMR, TPX2, CENPF, CDK1, CEP55, CEACAM1) were obtained. Gene expression heatmap showed that CEP55 and MELK were highly expressed in oral cancer samples. CEACAM1 was lowly expressed in oral cancer samples. CEACAM1, CEP55 and MELK were involved in tumor, inflammation, necrosis, and proliferation. Western blotting (WB) showed that CEACAM1 in oral cancer samples was lower than that in normal samples, after CEACAM1 knockdown, it was lower than that in oral cancer samples. Conclusion: CEACAM1 is lowly expressed in oral cancer, the lower CEACAM1, the worse prognosis.

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Trends in mouth cancer incidence in Mumbai, India (1995⿿2009): An age-period-cohort analysis

Cited by 14 publications

References 21 publications

Occurrence and Distribution of Cancers with Emphasis Upon Oral Cancers in Registered Oncology Institutes of South India – A Retrospective Study

Occurrence and Distribution of Cancers with Emphasis Upon Oral Cancers in Registered Oncology Institutes of South India – A Retrospective Study

Human papillomavirus in head and neck cancer in India: Current status and consensus recommendations

CEACAM1 as a molecular target in oral cancer

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