Trends in Methicillin-Resistant
            <i>Staphylococcus aureus</i>
            Anovaginal Colonization in Pregnant Women in 2005 versus 2009

Top, Karina A; Huard, Richard C.; Fox, Zachary; Wu, Fann; Whittier, Susan; Della‐Latta, Phyllis; Saiman, Lisa; Ratner, Adam J.

doi:10.1128/jcm.01129-10

Cited by 29 publications

(24 citation statements)

References 35 publications

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“…5,[21][22][23] Maternal vaginal MRSA colonization rates of 0.4 to 0.6% support this hypothesis, but concurrent maternal MSSA vaginal colonization prevalence of nearly 20-fold that of MRSA is contradictory. 24,25 This issue is further compounded by contradictory data in different reports noting cesarean section or vaginal delivery as risk factors supporting CA-MRSA colonization. 26,27 In a report by Saiman et al describing hospital transmission of CA-MRSA in postpartum women, infections presented at a mean of 23 days (range 4 to 73), suggesting that the latent period between exposure and disease with MRSA may be longer than previously appreciated.…”

Section: Mssa Versus Mrsa Tracheal Colonization and Pneumoniamentioning

confidence: 87%

Staphylococcus aureus, including Community-Acquired Methicillin-resistant S. aureus, in a Level III NICU: 2001 to 2008

et al. 2012

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Section: Mssa Versus Mrsa Tracheal Colonization and Pneumoniamentioning

confidence: 87%

Staphylococcus aureus, including Community-Acquired Methicillin-resistant S. aureus, in a Level III NICU: 2001 to 2008

et al. 2012

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“…In several recent reports, anovaginal S. aureus colonization was identified in 10 to 25% of pregnant women. [16][17][18][19][20] MRSA isolates were only identified in 0.5 to 10.4% of these women.…”

Section: Development Of Antibiotic Resistancementioning

confidence: 95%

Methicillin-Resistant Staphylococcus aureus in Obstetrics

Sheffield

2013

Amer J Perinatol

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Methicillin-resistant Staphylococcus aureus (MRSA) remains one of the major multiple antibiotic-resistant bacterial pathogens causing serious community-associated and health care-associated infections. It is now pervasive in the obstetric population associated with skin and soft tissue infections, mastitis, episiotomy, and cesarean wound infections and urinary tract infections. This review addresses the epidemiology, definitions, microbiology, and pathogenesis as well as common clinical presentations. A discussion of the 2011 Infectious Diseases Society of America MRSA treatment guidelines details available antibiotics, invasive and noninvasive MRSA management, and specific factors related to obstetrics. Finally, prevention strategies including decolonization are discussed.

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“…[22] Similarly, Top et al reported MSSA and MRSA anovaginal colonization rates of 11.8% and 0.6%, respectively, in pre-partum women, although neonatal colonization was not assessed. [23] These findings suggest that vertical transmission of S. aureus occurs, but is more relevant for MSSA than MRSA, presumably because fewer women are colonized with MRSA.…”

Section: Discussionmentioning

confidence: 99%

Epidemiology ofStaphylococcus aureusin Neonates on Admission to a Chinese Neonatal Intensive Care Unit

Geng

et al. 2019

Preprint

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25Purpose: Little is known about the molecular epidemiology of Staphylococcus aureus in 26 Chinese neonatal intensive care units (NICUs). We describe the molecular epidemiology of S. 27 aureus isolated from neonates on admission to Beijing Children's Hospital. 28 29 Methods: From May 2015-March 2016, nasal swabs were obtained on admission from 536 30 neonates. Cultures were also obtained from body sites with suspected infections. S. aureus 31 isolates were characterized by staphylococcal chromosomal cassette (SCCmec) type, 32 staphylococcal protein A (spa) type, multilocus sequence type (MLST), sasX gene, antimicrobial 33 susceptibility and cytotoxicity. Logistic regression assessed risk factors for colonization. 34 35Results: Overall, 92 (18%) infants were colonized with S. aureus and 23 (4%) were diagnosed 36 with culture-positive S. aureus infection. Of the colonized infants, 72% harbored MSSA, while 37 74% of infected infants were culture-positive for MRSA. Risk factors for colonization included 38 female sex, age 7-28 days, birthweight and vaginal delivery. The most common MRSA and 39 MSSA clones were community-associated ST59-SCCmecIVa-t437 (60%) and ST188-t189 40 (15%), respectively. The sasX gene was not detected. Some MSSA isolates (16%) were 41 penicillin-susceptible and some MRSA isolates (18%) were oxacillin-susceptible. MRSA and 42 MSSA had similar cytotoxicity, but colonizing strains were less cytotoxic than strains associated 43 with infections. 44 45 Conclusions: S. aureus colonization was common in infants admitted to our NICU and two 46 community-associated clones predominated. Several non-modifiable risk factors for S. aureus 50 51 Key words: Staphylococcus aureus, neonatal intensive care unit, colonization, MRSA, MSSA 52 4 53 54 Staphylococcus aureus infections represent a significant clinical burden for infants worldwide 55 and were recently found to be the second most common cause of late-onset sepsis in very-low 56 birth weight (VLBW) infants admitted to neonatal intensive care units (NICU) in the United 57 States and United Kingdom.[1, 2] Preterm infants are also at high risk for S. aureus 58 colonization[3], a potential risk factor for subsequent infection. In a recent meta-analysis 59 involving patients admitted to NICUs and ICUs, methicillin-resistant S. aureus (MRSA) 60 colonization was associated with a 24.2 times increased MRSA infection risk.[4] Endemic 61 transmission and outbreaks due to MRSA and methicillin-susceptible S. aureus (MSSA) occur 62 frequently in NICUs.[5] Studying the molecular epidemiology and virulence factors of S. aureus 63 in the NICU population can promote an increased understanding of pathogenesis and ultimately 64 guide preventive strategies. 65 66 While the molecular characteristics of and risk factors for S. aureus colonization and infection 67 have been described for NICU populations across the globe and have increased our knowledge of 68 the global burden,[3, 6] no previous reports have described the molecular characteristics of S. 69 aureus strains...

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Trends in Methicillin-Resistant Staphylococcus aureus Anovaginal Colonization in Pregnant Women in 2005 versus 2009

Cited by 29 publications

References 35 publications

Staphylococcus aureus, including Community-Acquired Methicillin-resistant S. aureus, in a Level III NICU: 2001 to 2008

Staphylococcus aureus, including Community-Acquired Methicillin-resistant S. aureus, in a Level III NICU: 2001 to 2008

Methicillin-Resistant Staphylococcus aureus in Obstetrics

Epidemiology ofStaphylococcus aureusin Neonates on Admission to a Chinese Neonatal Intensive Care Unit

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