Trends in local therapy application for early breast cancer patients in the Japanese Breast Cancer Society Breast Cancer Registry during 2004–2009

Saji, Shigehira; Hiraoka, Masahiro; Tokuda, Yutaka; Fukui, Naohito; Ikeda, Tadashi

doi:10.1007/s12282-011-0308-z

Cited by 23 publications

(10 citation statements)

References 2 publications

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“…Similar increase in trends in breast-conserving surgery has been observed in Japan also [18]. However, different trends in surgical methods were found in the United States.…”

Section: Discussionsupporting

confidence: 69%

Changing Patterns in the Clinical Characteristics of Korean Breast Cancer from 1996-2010 Using an Online Nationwide Breast Cancer Database

Noh²,

Kang

et al. 2012

J Breast Cancer

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PurposeBreast cancer is one of the most frequent malignancies in Korean women, and its incidence is increasing at a rapid rate. Since 1996, the Korean Breast Cancer Society has collected nationwide breast cancer data using an online registration program and analyzed the data biennial. The purpose of this study was to evaluate the characteristics of Korean breast cancer and to analyze changes in these characteristics over the period of time.MethodsData were collected from 41 medical schools (74 hospitals), 24 general hospitals, and 6 private clinics. Data on the total number, gender, and age of newly-diagnosed breast cancer patients were collected through a questionnaire. Additional data were collected and analyzed from the online database.ResultsIn 2010, 16,398 patients in Korea were newly diagnosed with breast cancer. The crude incidence rate of female breast cancer was 67.2 cases per 100,000, and the median age at diagnosis was 49 years. The incidence of breast cancer was highest in patients aged between 40 and 49 years. Since 1996, there has been a significant increase in the proportion of early-stage cancers (detected in stage 1 or 2), the percentage of estrogen receptor-positive cancers, and in the proportion of patients receiving breast-conserving surgery.ConclusionThe incidence and clinical characteristics of Korean breast cancer are slowly changing to the patterns of Western countries. To understand changing patterns in the characteristics of Korean breast cancer, the nationwide data should be continuously analyzed.

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“…Similar increase in trends in breast-conserving surgery has been observed in Japan also [18]. However, different trends in surgical methods were found in the United States.…”

Section: Discussionsupporting

confidence: 69%

Changing Patterns in the Clinical Characteristics of Korean Breast Cancer from 1996-2010 Using an Online Nationwide Breast Cancer Database

Noh²,

Kang

et al. 2012

J Breast Cancer

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“…In Japan, reported rates of breast conserving surgery increased from 2004 to 2007, and reached a plateau between 2007 and 2009 [20]. However, in the United States, different trends have been noted in the surgical treatment of breast cancer.…”

Section: Discussionmentioning

confidence: 99%

The Basic Facts of Korean Breast Cancer in 2011: Results of a Nationwide Survey and Breast Cancer Registry Database

et al. 2014

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Breast cancer is the second most frequent malignancy in Korean women, with a continuously increasing incidence. The Korean Breast Cancer Society has constructed a nationwide breast cancer database through an online registration program. The aim of the present study was to report the fundamental facts on Korean breast cancer in 2011, and to analyze the changing patterns in clinical characteristics and breast cancer management in Korea over the last 10 years. Data on newly diagnosed breast cancer patients, including the total number of cases, age, stage, and type of surgery, for the year 2011 were collected from 84 hospitals and clinics nationwide using a questionnaire survey. Additional data relating to the changing patterns of breast cancer in Korea were collected from the online breast cancer registry database and analyzed. According to nationwide survey data, a total of 16,967 patients were newly diagnosed with breast cancer in 2011. The crude incidence of female breast cancer, including invasive cancer and in situ cancer, was 67 cases per 100,000 women. Analysis of the survey and registry data gave equivalent results in terms of age distribution, stage, and type of surgery. The median age at diagnosis was 50 years, and the proportion of postmenopausal women (51.3%) was higher than that of premenopausal women (48.7%) with breast cancer. The incidence of stage 0 and stage I breast cancer increased continuously over the last 10 years (56.3% in 2011), and breast conserving surgery (65.7%) was performed more frequently than total mastectomy (33.8%). The total number of breast reconstruction surgeries increased approximately 8-fold. We conclude that the clinical characteristics of breast cancer have changed over the past 10 years in Korea, and surgical management has changed accordingly. Analysis of nationwide registry data will contribute to a better understanding of the characteristics of breast cancer in Korea.

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“…The following factors were investigated: T stage (T1 vs. T2), N stage (N0 vs. N1), ER (negative vs. positive), HER2 (negative vs. positive), Ki67 LI (Eye-5 grade 1-3 vs. [4][5]. Univariate analysis was performed and factors with p<0.5 were used to perform multivariate analysis.…”

Section: Discussionmentioning

confidence: 99%

“…3) Since 2003, BCT has been performed more often than mastectomy to treat invasive stage I-II breast cancer in Japan. 4) Local treatment during BCT includes BCT itself and the administration of postoperative radiotherapy to the entire breast on the affected side. Postoperative radiotherapy decreases postoperative recurrence by one third and improves the survival rate.…”

Section: Introductionmentioning

confidence: 99%

Ki67 Labeling Index Predicts Poor Long-term Relapse-free Survival in Patients with Invasive Stage I-II Breast Cancer After Breast-conserving Therapy

Abe

Okada

Shinozaki

et al. 2017

J St. Marianna Univ

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Background: The purpose of this retrospective study was to investigate the predictive ability of the Ki67 labeling index (LI) for relapse-free survival (RFS) of patients with stage I-II invasive breast cancer after breast-conserving therapy. Materials and methods: Between 2012 and 2016, 240 patients with stage I-II invasive breast cancer were treated at our hospital with breast-conserving therapy. Survival outcomes were analyzed using the Kaplan-Meier and cumulative incidence methods. Factors including T stage, N stage, estrogen receptor, HER2, and Ki67 LI were evaluated with regard to RFS using Cox proportional hazard regression. Results: The median duration of follow-up in the surviving patients was 36 months (range, 14-62 months). Rates of 3-year overall survival and RFS were 98.1% and 96.4%, respectively. Three-year cumulative rates of local recurrence, regional recurrence, and distant metastasis were 1.3%, 1.2%, and 2.1%, respectively. Multivariate analysis revealed that a Ki67 LI ≥33.3% was the only prognostic factor for RFS. Conclusion: A Ki67 LI ≥33.3% was a predictor of significantly worse RFS.

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Trends in local therapy application for early breast cancer patients in the Japanese Breast Cancer Society Breast Cancer Registry during 2004–2009

Cited by 23 publications

References 2 publications

Changing Patterns in the Clinical Characteristics of Korean Breast Cancer from 1996-2010 Using an Online Nationwide Breast Cancer Database

Changing Patterns in the Clinical Characteristics of Korean Breast Cancer from 1996-2010 Using an Online Nationwide Breast Cancer Database

The Basic Facts of Korean Breast Cancer in 2011: Results of a Nationwide Survey and Breast Cancer Registry Database

Ki67 Labeling Index Predicts Poor Long-term Relapse-free Survival in Patients with Invasive Stage I-II Breast Cancer After Breast-conserving Therapy

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