Trends in liver profile and nutrition outcomes in children undergoing intestinal rehabilitation using a mixed lipid injectable emulsion

Wassef, Jessica; Lipkin, Elizabeth; Hardigan, Patrick C.; Duro, Debora

doi:10.1002/ncp.10782

Cited by 2 publications

(1 citation statement)

References 22 publications

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“…Overall, studies investigating effects of HPN with SMOFlipid (doses up to 3 g lipids/kg BW/day) for varying durations ranging from 4 weeks to 6.6 years consistently report benefits in terms of the correction or prevention of liver disease following SMOFlipid administration [48,90,94,112].…”

Section: Effects On Cholestasis/liver Functionmentioning

confidence: 96%

An Overview of Parenteral Nutrition from Birth to Adolescence Based on a Composite Fish Oil Containing Lipid Emulsion and a Pediatric Amino Acid Solution

Goulet

2024

Nutrients

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Intestinal failure (IF) is characterized by a critical reduction in functional gut mass below the minimum needed for optimal growth in children. It requires parenteral nutrition (PN) and home-PN (HPN), which is challenging in terms of meeting nutritional needs according to age, growth velocity, clinical situation, and rapid changes in fluid and electrolyte requirements. Due to these complex requirements, age-adapted multi-chamber bags (MCBs) are important additions to the nutrition armamentarium. The launch of composite fish oil (FO)-containing intravenous lipid emulsions (ILEs) heralded the development of MCBs containing these ILEs in combination with a crystalline amino acid solution adapted for pediatric use. The safety and efficacy of lipid and amino acid components in this context have been widely documented in numerous published studies. This narrative manuscript includes a review of the articles published in PudMed, Embase, and Google Scholar up to June 2023 for the age groups of term infants to children and adolescents. Preterm infants with their highly specific demands are not included. It aims to offer an overview of the clinical experience regarding the use of a composite FO-based ILE and a developed specific amino acid solution.

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Section: Effects On Cholestasis/liver Functionmentioning

confidence: 96%