Trends in liver cancer mortality in the United States: Dual burden among foreign‐ and US‐born persons

Endeshaw, Meheret; Hallowell, Benjamin D; Razzaghi, Hilda; Senkomago, Virginia; McKenna, Matthew T.; Saraiya, Mona

doi:10.1002/cncr.31869

Cited by 37 publications

(17 citation statements)

References 32 publications

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“…HCC is one of the most commonly seen malignant tumours and is the third leading the global digestive system tumour in terms of its mortality; the morbidity and mortality of HCC also show increasing trends [27,28]. The leading causes of HCC are chronic hepatitis viral infection (such as HBV and HCV), liver cirrhosis, malnutrition, toxin invasion and metabolic disturbance.…”

Section: Discussionmentioning

confidence: 99%

HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma

Chen

Cui

et al. 2020

BMC Med Genomics

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Background: DNA methylation is a common chemical modification of DNA in the carcinogenesis of hepatocellular carcinoma (HCC). Methods: In this bioinformatics analysis, 348 liver cancer samples were collected from the Cancer Genome Atlas (TCGA) database to analyse specific DNA methylation sites that affect the prognosis of HCC patients. Results: 10,699 CpG sites (CpGs) that were significantly related to the prognosis of patients were clustered into 7 subgroups, and the samples of each subgroup were significantly different in various clinical pathological data. In addition, by calculating the level of methylation sites in each subgroup, 119 methylation sites (corresponding to 105 genes) were selected as specific methylation sites within the subgroups. Moreover, genes in the corresponding promoter regions in which the above specific methylation sites were located were subjected to signalling pathway enrichment analysis, and it was discovered that these genes were enriched in the biological pathways that were reported to be closely correlated with HCC. Additionally, the transcription factor enrichment analysis revealed that these genes were mainly enriched in the transcription factor KROX. A naive Bayesian classification model was used to construct a prognostic model for HCC, and the training and test data sets were used for independent verification and testing. Conclusion: This classification method can well reflect the heterogeneity of HCC samples and help to develop personalized treatment and accurately predict the prognosis of patients.

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Section: Discussionmentioning

confidence: 99%

HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma

Chen

Cui

et al. 2020

BMC Med Genomics

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“…As far as we know, current studies of LC incidence or mortality have been mainly limited to specific regions and populations or have focused on the short-term trends of a particular indicator of mortality or morbidity [15,16,17,18], and most research globally has used data from national cancer surveillance agencies, such as the Chinese National Cancer Center, the U.S. Census Bureau, or Statistics South Africa, which has some limitations for global comparison [19,20]. However, some studies have only analyzed crude trends, and besides, few investigations have studied the simultaneous incidence and mortality trend of liver cancer in China by using age–period–cohort (APC) analysis, which can separate age, period, and cohort effects [21].…”

Section: Introductionmentioning

confidence: 99%

Long-Term Trends of Liver Cancer Incidence and Mortality in China 1990–2017: A Joinpoint and Age–Period–Cohort Analysis

Wang

Mubarik

Zhang

et al. 2019

IJERPH

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Liver cancer (LC) is one of the most common causes of cancer-related deaths: this study aims to present the long-term trends and age–period–cohort effects of the incidence of and mortality from LC in China during 1990–2017. Incidence and mortality data were obtained from the Global Burden of Disease Study 2017. We determined trends in the age-standardized incidence rate (ASIR) and mortality rate (ASMR) using Joinpoint regression. An age–period–cohort (APC) analysis was performed to describe the long-term trends with intrinsic estimator methods. The ASMR decreased markedly before 2013 and increased thereafter, with overall average annual percent change (AAPC) values of −0.5% (95% confidence interval (CI): −0.6%, −0.3%) for men and −1.3% (−1.6%, −1.0%) for women during 1990–2017. The ASIR significantly increased by 0.2% (0.1%, 0.3%) in men and decreased by 1.1% (−1.2%, −1.0%) in women from 1990 to 2017. The risks of LC incidence and mortality increased with age in both genders. The period effect risk ratios (RRs) of incidence and mortality displayed similar monotonic increasing trends in men and remained stable in women. The cohort effect showed an overall downward trend and almost overlapping incidence and mortality in both genders, and later birth cohorts experienced lower RRs than previous birth cohorts. Older age, recent period, and birth before 1923 were associated with a higher risk of liver cancer incidence and mortality. The net age and period effects showed an increasing trend, while the cohort effects presented a decreasing trend in incidence and mortality risk. As China’s population aging worsens and with the popularization of unhealthy lifestyles, the burden caused by liver cancer will remain a huge challenge in China’s future.

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“…(4,9,12) The Hispanic population is currently the second largest ethnic population in the United States, and the rising HCC mortality may be driven by increasing trends among Hispanic people. (8,9,13) There are racial and ethnic disparities in cancer diagnosis and treatment due to unique social determinants, support mechanisms, and access to health care. (14) These disparities can lead to increased cancer mortality.…”

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Hepatocellular Carcinoma in Hispanic Patients: Trends and Outcomes in a Large United States Cohort

et al. 2020

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Hepatocellular carcinoma (HCC) has a strong racial and ethnic association, with Hispanic patients having a higher incidence and mortality. However, there are limited data regarding clinical features and outcomes. This study includes Hispanic and non‐Hispanic White patients with HCC diagnosed between January 2000 and June 2014 from five United States academic medical centers. The chi‐square test for categorical variables and analysis of variance for continuous variables were used for statistical analysis, with two‐tailed P < 0.05 considered statistically significant. Of 5,327 patients, 4,217 met inclusion criteria, of whom 12.3% were Hispanic patients. Compared to their non‐Hispanic White counterparts, Hispanic patients were older at age of diagnosis (mean ± SD, 64.2 ± 10.9 vs. 61.9 ± 10.5 years; P < 0.0001), with higher body mass index (29.6 ± 6.5 vs. 28.8 ± 5.9 kg/m 2 ; P = 0.01), and were more likely to have diabetes and hypertension. Hispanic patients had significantly more nonalcoholic fatty liver disease and alcohol‐related liver disease (both P < 0.0001). Hispanic patients presented with larger tumors, more advanced stage disease, and increased rates of macrovascular invasion and extrahepatic spread. HCCs in Hispanic patients were less likely to be within Milan criteria (26% vs. 38%; P < 0.0001) and were less likely to be treated with resection (9% vs. 13%; P = 0.03) or transplantation (8% vs. 19%; P < 0.0001). Hispanic patients had a median overall survival of 1.4 years (95% confidence interval [CI], 1.22‐1.56), which was similar to that of non‐Hispanic White patients (1.3 years; 95% CI, 1.26‐1.41; P = 0.07). Conclusion : Hispanic patients with HCC were more likely to have metabolic risk factors for chronic liver disease, including obesity. Despite diagnosis at more advanced stages with less curative intervention than non‐Hispanic White patients, median overall survival was similar between groups.

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Trends in liver cancer mortality in the United States: Dual burden among foreign‐ and US‐born persons

Cited by 37 publications

References 32 publications

HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma

HDNA methylation data-based molecular subtype classification related to the prognosis of patients with hepatocellular carcinoma

Long-Term Trends of Liver Cancer Incidence and Mortality in China 1990–2017: A Joinpoint and Age–Period–Cohort Analysis

Hepatocellular Carcinoma in Hispanic Patients: Trends and Outcomes in a Large United States Cohort

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