Trends in Incidence Rates of Invasive Lobular and Ductal Breast Carcinoma

Li, Christopher I.; Anderson, Benjamin O.; Daling, Janet R.; Moe, Roger E.

doi:10.1001/jama.289.11.1421

Cited by 469 publications

(330 citation statements)

References 18 publications

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“…A steady increase in lobular carcinoma incidence suggests the importance of studying its mechanism [20]. A shorter latency period of ductal compared to lobular carcinoma obtained from our analysis could be due (at least in part) to higher proliferation and apoptosis [21].…”

Section: Discussionmentioning

confidence: 60%

Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms

Kravchenko

Akushevich

Seewaldt

et al. 2011

Breast Cancer Res Treat

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The observed bimodal patterns of breast cancer incidence in the U.S. suggested that breast cancer may be viewed as more than one biological entity. We studied the factors potentially contributing to this phenomenon, specifically focusing on how disease heterogeneity could be linked to breast carcinogenesis mechanisms. Using empirical analyses and population-based biologically motivated modeling, age-specific patterns of incidence of ductal and lobular breast carcinomas from the SEER registry (1990)(1991)(1992)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003) were analyzed for heterogeneity and characteristics of carcinogenesis, stratified by race, stage, grade, and estrogen (ER)/progesterone (PR) receptor status. The heterogeneity of breast carcinoma age patterns decreased after stratification by grade, especially for grade I and III tumors. Stratification by ER/PR status further reduced the heterogeneity, especially for ER(?)/PR(-) and ER(-)/(-) tumors; however, the residual heterogeneity was still observed. The number of rate-limiting events of carcinogenesis and the latency of ductal and lobular carcinomas differed, decreasing from grade I to III, with poorly differentiated tumors associated with the least number of carcinogenesis stages and the shortest latency. Tumor grades play important role in bimodal incidence of breast carcinoma and have distinct mechanisms of carcinogenesis. Race and cancer subtype could play modifying role. ER/PR status contributes to the observed heterogeneity, but is subdominant to tumor grade. Further studies on sources of ''remaining'' heterogeneity of population with breast cancer (such as genetic/epigenetic characteristics) are necessary. The results of this study could suggest stratification rather than unification of breast cancer prevention strategies, risk assessment, and treatment.

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Section: Discussionmentioning

confidence: 60%

Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms

Kravchenko

Akushevich

Seewaldt

et al. 2011

Breast Cancer Res Treat

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“…With an incidence of 5-15 %, invasive lobular carcinoma (ILC) represents the second most common histological type of breast cancer, with distinct clinical, biological and molecular features compared with non-lobular carcinoma (non-ILC) [1,2]. In comparison with non-ILC, ILC is significantly more likely to occur in older patients, to be of larger size, hormone-receptor positive, of intermediate grade and without vascular invasion [3,4].…”

Section: Introductionmentioning

confidence: 99%

Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma

Loibl

Volz

Mau

et al. 2014

Breast Cancer Res Treat

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Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma 123Breast Cancer Res Treat (2014) 144:153-162 DOI 10.1007/s10549-014-2861 pCR and this is not well correlated with further outcome. The mastectomy rate was considerably high in ILC patients even after obtaining a pCR. We, therefore, suggest to offer NACT mainly to ILC patients with HR-negative tumours.

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“…Most occult metastases belong to the less common histological type, infiltrating lobular as opposed to infiltrating ductal carcinoma (IDC). Ovarian metastasis more commonly occurs in advanced-stage cancer [19,27].…”

Section: Introductionmentioning

confidence: 99%

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

Luyckx

Durant

Camboni

et al. 2013

J Assist Reprod Genet

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Trends in Incidence Rates of Invasive Lobular and Ductal Breast Carcinoma

Cited by 469 publications

References 18 publications

Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms

Breast cancer as heterogeneous disease: contributing factors and carcinogenesis mechanisms

Response and prognosis after neoadjuvant chemotherapy in 1,051 patients with infiltrating lobular breast carcinoma

Is transplantation of cryopreserved ovarian tissue from patients with advanced-stage breast cancer safe? A pilot study

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