Trends in Incidence of Urinary Tract Infection in Mainland China from 1990 to 2019

Yuan, Shengjie; Shi, Ying; Li, Minmin; Hu, Xiaojun; Bai, Ruhai

doi:10.2147/ijgm.s305358

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…The APC can be considered essentially as a multiple regression model which was developed based on the Poisson distribution. The specific equation was exhibited as follows: 13 Υ = μ + α A ≥ Υ i + β Period j + γ Cohort k + ε…”

Section: Methodsmentioning

confidence: 99%

Temporal Trend of Urolithiasis Incidence in China: An Age–Period–Cohort Analysis

Huang

Fan

et al. 2021

IJGM

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Purpose Urolithiasis is one of the commonest disease of the urinary system. This study aimed to assess the long-term urolithiasis incidence trends in China between 1990 and 2019. Patients and Methods The incidence data of urolithiasis were extracted from Global Burden of Disease Study 2019, and an age–period–cohort framework was used to estimate the age, period, and cohort effects. Results We found that the net drift was −2.72% (95% CI: −2.84% to −2.60%) per year for men and −2.14% (95% CI: −2.24% to −2.05%) per year for women, and except men in age group 0–4, the local drift values were below 0 in all age groups (P<0.05 for all) in both sexes during the period of 1990 to 2019. In the same birth cohort, the risk of incidence from urolithiasis rose first and then decreased with age for both sexes after controlling for period deviations, and in addition, after 20 years old, the risk of incidence of urolithiasis in men was higher than that in women (significantly with P<0.05). In general, the estimated period and cohort relative risks were found in similar downward patterns for both sexes. Conclusion In the past 30 years, the age-standard incidence of urolithiasis in both sex of Chinese people has decreased, but the crude incidence of urolithiasis in Chinese women has increased. Considering the aging of population structure in China, the overall number of female urolithiasis patients may increase, contributes to higher crude incidence rate. The problem of urolithiasis in Chinese women needs to be paid more attention.

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Section: Methodsmentioning

confidence: 99%

Temporal Trend of Urolithiasis Incidence in China: An Age–Period–Cohort Analysis

Huang

Fan

et al. 2021

IJGM

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“…The same increasing trend was observed in multiple previous studies [39][40][41][42], observing infectious episodes more frequently in patients with other associated comorbidities, such as diabetes, renal failure, or urinary lithiasis [43]. However, other authors also present slightly different data regarding the incidence of age-related UTIs; in China, Yuan S et al describe in a large cohort of patients a linear increase in incidence until the age of 30, followed by a slight decrease until the age of 40, and then an increase again until the age of 60, from where it gradually decreases [44]. Another work from Iraq by Salwa Y. showed an increase in the number of incident cases of infection until the age of 30, and then the incidence decreased in the following decade [45].…”

Section: The Incidence Of Uropathogens In Utis and Relation To Patien...mentioning

confidence: 99%

Update on Urinary Tract Infection Antibiotic Resistance—A Retrospective Study in Females in Conjunction with Clinical Data

Mareș,

Petca,

Popescu

et al. 2024

Life

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Urinary tract infections (UTIs) represent a frequent pathology among the female population that has become more and more difficult to treat in the past decade, considering the increase in antibiotic resistance—a serious global public health problem. A cross-sectional retrospective study was conducted for six months to report an update regarding the rates of resistance and susceptibility of uropathogens necessary for optimal treatment. A total of 5487 patients were screened, of which 524 (9.54%) were female patients who met the criteria for inclusion in the study. Escherichia coli was the most common pathogen, representing 290 cases (55.34%), followed by Enterococcus spp. 82 (15.64%). Escherichia coli presented the highest resistance to amoxicillin-clavulanic acid (R = 33.1%), followed by trimethoprim-sulfamethoxazole (R = 32.41%) and levofloxacin (R = 32.06%). The highest sensitivity rates were observed for fosfomycin (S = 96.55%), followed by imipenem (S = 93.1%). Enterococcus spp. showed the highest resistance to levofloxacin (R = 50.0%), followed by penicillin (R = 39.02%). The highest sensitivity was observed for fosfomycin (S = 90.24%), linezolid (S = 89.02%), and nitrofurantoin (S = 86.58%). The second most frequent Gram-negative uropathogen was represented by Klebsiella spp., which had the highest resistance to amoxicillin-clavulanic acid (R = 35.89%), followed by levofloxacin (R = 25.64) and trimethoprim-suflamethoxazole (R = 24.35%). The most frequently associated pathology was an episode of UTI in the previous year, followed by diabetes and chronic kidney disease. Antibiotic resistance is a serious problem for all clinicians who treat UTIs. An up-to-date knowledge of antibiotic resistance rates is a major necessity to stop its evolution. Overall, the highest resistance rates were observed for aminopenicillins, fluoroquinolones, and trimethoprim-sulfamethoxazole. The best susceptibility rates were observed for fosfomycin, nitrofurantoin, and carbapenems. Our report aims to guide clinicians whenever they are forced to prescribe antibiotics empirically.

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Section: Introductionmentioning

confidence: 99%

“…3 In China between 2006 and 2016, cases of urinary tract infections accounted for 11.65% of all healthcare-related infections, 4 and in the past three decades, there has been a notable surge in elderly women developing such infections. 5 K. pneumoniae is a significant causative agent of UTI, which can result in high rates of illness and death. 6,7 Due to the high empiric use of antibiotics for the treatment of UTI, the antibiotic resistance of K. pneumoniae increased significantly worldwide.…”

Section: Introductionmentioning

confidence: 99%

Hybrid Sequencing-Based Genomic Analysis of Klebsiella pneumoniae from Urinary Tract Infections Among Inpatients at a Tertiary Hospital in Beijing

Zhang,

Wang,

Wang

et al. 2024

IDR

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Background Urinary tract infection (UTI) associated with Klebsiella pneumoniae poses a serious threat for inpatients. This study aimed to describe the genomic characteristics of K. pneumoniae causing UTI in a tertiary-care hospital in Beijing, China. Methods A total of 20 K. pneumoniae strains collected from 2020 to 2021 were performed whole-genome sequencing. The Antibiotic susceptibility of 19 common antimicrobial agents was tested against all strains. The multi-locus sequence types (MLSTs) and serotypes were determined from the WGS data. De novo assemblies were used to identify resistance and virulence genes. The presence and characteristics of the plasmids were detected using hybrid assembly of long and short-read data. Results These K. pneumoniae strains were clustered into nine sequence types (STs) and twelve K-serotypes. All the carbapenem-resistant K. pneumoniae (CRKP) strains acquired carbapenemase bla KPC-2 (n=7). Two CRKP strains exhibited increased resistance to Polymyxin B with MIC ≥ 4 mg/L due to insertion of an IS5-like sequence in the mgrB gene, and they were also involved in a transmission event in Intensive Care Unit. Long-read assemblies identified many plasmids co-carrying multiple replicons. Acquisition of a new IncM2_1 type bla CTX-M-3 positive plasmid was observed after transfer from ICU to neurovascular surgery by comparing the two strains collected from the same patient. Conclusion K. pneumoniae is a significant pathogen responsible for urinary tract infections. The ST11-KL47 strain, prevalent at our hospital, exhibits a combination of high drug resistance and hypervirulence. It is imperative to enhance ongoing genomic surveillance of urinary tract infection-causing pathogens.

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Trends in Incidence of Urinary Tract Infection in Mainland China from 1990 to 2019

Cited by 5 publications

References 34 publications

Temporal Trend of Urolithiasis Incidence in China: An Age–Period–Cohort Analysis

Temporal Trend of Urolithiasis Incidence in China: An Age–Period–Cohort Analysis

Update on Urinary Tract Infection Antibiotic Resistance—A Retrospective Study in Females in Conjunction with Clinical Data

Hybrid Sequencing-Based Genomic Analysis of Klebsiella pneumoniae from Urinary Tract Infections Among Inpatients at a Tertiary Hospital in Beijing

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