Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries

Botterweck, A.A.M.; Schouten, Leo J.; Volovics, A.; Dorant, E.; Brandt, Piet A. van den

doi:10.1093/ije/29.4.645

Cited by 482 publications

(333 citation statements)

References 27 publications

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“…20 In the Netherlands and some countries, however, previous studies showed no increase in the incidence of cardia cancer. 21,22 Our results confirm this, although in the most recent period a small proportional rise was seen in cardia carcinoma. Some suggest that misclassification of distal oesophageal cancer as gastric cardia cancer explains the non-increasing incidence of cardia carcinoma.…”

Section: Discussionsupporting

confidence: 84%

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

Dassen¹,

Lemmens²,

Poll‐Franse³

et al. 2010

European Journal of Cancer

136

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General rightsCopyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights.-Users may download and print one copy of any publication from the public portal for the purpose of private study or research -You may not further distribute the material or use it for any profit-making activity or commercial gain -You may freely distribute the URL identifying the publication in the public portal Take down policyIf you believe that this document breaches copyright, please contact us providing details, and we will remove access to the work immediately and investigate your claim. Conclusion:The absence of improvement in survival rates indicates the need for earlier detection and prospective studies to evaluate new therapy regimens with standardised surgery and pathology.

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Section: Discussionsupporting

confidence: 84%

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

Dassen¹,

Lemmens²,

Poll‐Franse³

et al. 2010

European Journal of Cancer

136

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“…The incidence of oesophageal adenocarcinoma has risen at a greater rate than any other malignancy in the USA and most European regions, currently varying from one in 146 to one in 285 cases/patient/year (Drewitz et al, 1997;O'Connor et al, 1999;Botterweck et al, 2000;Nilsson et al, 2000;Conio et al, 2001). Adenocarcinoma of the oesophagus almost always arises as a consequence of the neoplastic progression of Barrett's oesophagus and has a poor prognosis, with 5-year survival rates of only 10% (Farrow and Vaughan, 1996).…”

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confidence: 99%

Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma

et al. 2003

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p53 mutations and loss of heterozygosity have been commonly associated with oesophageal adenocarcinoma. In this investigation, the p53 status of a Welsh population of Barrett's-associated oesophageal adenocarcinomas were fully characterised at the gene sequence, chromosomal, mRNA and protein levels. In total, 31 tumours were examined for p53 gene sequence mutations using RFLP with sequencing, allelic loss of the gene was characterised by FISH, mRNA expression by p53 pathway signalling arrays and protein levels by p53 immunohistochemistry. In all, 9.6% of adenocarcinomas harboured p53 mutations, 24% displayed p53 allelic loss and 83% exhibited p53 protein accumulation. Point mutations and deletions of the gene did not coexist within the same samples. All samples containing p53 mutations also displayed positive immunostaining; however; in the majority of cases, p53 protein accumulation developed in the absence of mutations. The gene expression analysis demonstrated no differences in p53 and mdm-2 transcription levels between the p53 immunonegative and immunopositive samples, indicating other mechanisms underlie the proteins' overexpression. In conclusion, p53 mutations and deletions do not appear to be frequent events in oesophageal adenocarcinomas; however, abnormal accumulation of the protein is present in a vast majority of cases. P53 gene mutations are not the primary cause of protein overexpression -an alternative mechanism is responsible for the positive p53 immunohistochemistry detected.

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“…4 The incidence of these 2 types of cancers has progressively risen in the Western world. 2,[5][6][7][8] However, at the present time, it is impossible to predict which patients are at risk of neoplastic progression and all patients are advised to undergo a regular endoscopic followup. 9,10 BE patients have a 30 -125-fold increased risk of developing esophageal AC compared to the general population.…”

mentioning

confidence: 99%

Risk factors for Barrett's esophagus: A case‐control study

Conio¹,

Filiberti²,

Blanchi³

et al. 2001

Intl Journal of Cancer

138

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Barrett's esophagus (BE) is an acquired disorder due to chronic gastroesophageal reflux. Environmental factors seem to play an important role in the pathogenesis of BE, especially in Western society. A multicenter case-control study was carried out between February 1995 and April 1999 in 8 Italian Departments of Gastroenterology gathered in a study group (GOSPE), in order to analyze the influence of some individual characteristics and life-style habits on the occurrence of BE. Three groups of patients were studied: 149 patients with BE, 143 patients with esophagitis (E) and 308 hospital controls (C) with acute, non-neoplastic, non-gastroenterological conditions. The diagnosis of BE was based on endoscopy and histology. E was defined by the Savary classification (grade I-III). Data collection was performed by using a questionnaire that focused on smoking, coffee and alcohol consumption, medical history, drugs history, gastroesophageal reflux disease (GERD) symptoms (heartburn, regurgitation) and socio-economic status. Multivariate analysis showed that the frequency of weekly GERD symptoms was significantly associated with both BE and E (p<0.0001), such as the presence of hiatal hernia (p<0.001). Ulcer was significantly associated with BE (p‫.)100.0؍‬ Among patients with E, the risk was directly related to spirits consumption (p‫.)30.0؍‬ Patients with GERD symptoms that lasted more than 13 years were more likely to have BE than E (p‫.)10.0؍‬ In conclusion, results from our study point out that long-standing GERD symptoms, hiatal hernia and possibly alcohol consumption are risk factors in the development of the BE and E.

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Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries

Abstract: This study, using Eurocim data, supports the findings from other time-trend studies of population-based cancer registries in western countries.

Cited by 482 publications

References 27 publications

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

Trends in incidence, treatment and survival of gastric adenocarcinoma between 1990 and 2007: A population-based study in the Netherlands

Characterisation of p53 status at the gene, chromosomal and protein levels in oesophageal adenocarcinoma

Risk factors for Barrett's esophagus: A case‐control study

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