Trends in incidence for gestational trophoblastic disease over the last 20years in a population-based study

Clinical presentation and treatment outcome of molar pregnancy: Ten years experience at a Tertiary Care Hospital in Dammam, Saudi Arabia

“…The incidence of molar pregnancy is 0.5-1 per 1000 pregnancies in North America and Europe, 2 per 1000 pregnancies in Southeast Asia, 1 per 250 pregnancies in Philippines, and much higher in Taiwan, 1 per 125 pregnancies. [34] These variations may be attributed to the difference in the reporting data source, whether population-based or hospital-based. The other factors that may be responsible for this variation in the occurrence of molar pregnancy include socioeconomic and nutritional factors.…”

Type I interferons modulate methotrexate resistance in gestational trophoblastic neoplasia

“…30 Accumulating significant amounts of clinical material is difficult given the low prevalence of these diseases in the general population. 32,33 Still, specialized referral centers for GTD such as our centers continue to see patients with chemotherapy resistance, some of whom die from what is conventionally considered a curable disease. 32,33 Still, specialized referral centers for GTD such as our centers continue to see patients with chemotherapy resistance, some of whom die from what is conventionally considered a curable disease.…”

“…8,31 Furthermore, most women with molar pregnancies do not develop GTN, and among those that do, only a minority will have chemotherapy resistance or high-risk disease. 32,33 Still, specialized referral centers for GTD such as our centers continue to see patients with chemotherapy resistance, some of whom die from what is conventionally considered a curable disease. Consequently, we undertook the present study to develop a simple in vitro model which could be used to spur discovery for novel biomarkers and treatments for GTN.…”

Accuracy of p57KIP2 compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta‐analysis

“…The incidence is approximately 1–3 in 1000 pregnancies for complete hydatidiform mole (CHM) and 3 in 1000 pregnancies for partial hydatidiform mole (PHM) in North America and Europe; both conditions appear to be diagnosed more often in Asia and Latin America 2, 3. Some studies show that cases are ten times more likely in some Asian or African countries 4, 5, 6. In Brazil, there is no official gestational trophoblastic disease registry, and this disease, despite its important morbidity and psychosocial impact, may be underestimated at 1/200–800 gestations, depending on the geographical region 7, 8…”

“…2,3 Some studies show that cases are ten times more likely in some Asian or African countries. [4][5][6] In Brazil, there is no official gestational trophoblastic disease registry, and this disease, despite its important morbidity and psychosocial impact, may be underestimated at 1/200-800 gestations, depending on the geographical region. 7,8 Histopathological examination remains the basis for the diagnosis of HM; however, the diagnosis and classification of HM have become increasingly difficult because HMs are now commonly evacuated at an earlier stage and do not satisfy the well-established classic morphological features.…”