Trends in incidence and associated risk factors of suicide mortality among breast cancer patients

Gaitanidis, Apostolos; Alevizakos, Michail; Pitiakoudis, Michail; Wiggins, Doreen L.

doi:10.1002/pon.4570

Cited by 32 publications

(55 citation statements)

References 36 publications

(59 reference statements)

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“…Our study showed that the suicide rates of the white race and other races were respectively 2.77 and 1.34 times higher than that of the black race. Furthermore, the black race was proved to be a protective factor of suicide, matching the findings in previous investigations . In terms of the black race, this finding might be explained by religious beliefs, family support, and culture of rejecting suicide .…”

Section: Discussionsupporting

confidence: 86%

“…Some recent publications showed that older age was a predictor of suicide for cancer patients and the common population . Interestingly, older breast cancer patients who fare better in terms of functional status than younger patients were less likely to commit suicide . In our study, a tendency of increased suicide rate with age was also observed, although without statistical association.…”

Section: Discussioncontrasting

confidence: 52%

“…However, this finding was contrary to the previous research by Gaitanidis that earlier disease stage and lower tumor grade were associated with higher risks of committing suicide among breast cancer patients. This conflicting result might be partially attributed to the fact that all the patients with breast cancer enrolled in the study had passed away …”

Section: Discussionmentioning

confidence: 99%

“…For the behavior of suicide could be potentially recognized and prevented, the identification of patients with high‐risk factors of suicide was particularly important. The risk factors including male sex, white race, and unmarried status were demonstrated to be associated with a high incidence of suicide for some types of cancer, such as breast cancer, colorectal cancer, and pancreatic cancer …”

Section: Introductionmentioning

confidence: 99%

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Risk factors associated with suicide among kidney cancer patients: A Surveillance, Epidemiology, and End Results analysis

et al. 2019

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Background The suicide risk was higher in kidney cancer patients than in the general population. The purpose of this study was to characterize the suicide rates among kidney cancer patients and to identify the potential risk factors associated with suicide from the Surveillance, Epidemiology, and End Results (SEER) database. Methods Kidney cancer patients were identified from the SEER database during 1973‐2015. Suicide rates and standardized mortality ratios (SMRs) of this population were calculated, and the US general population during 1981‐2015 was chosen as a reference. Univariable and multivariable Cox regression were performed to find out potential risk factors of suicide. Results There were 207 suicides identified among 171 819 individuals with kidney cancer observed for 948 272 person‐years. The suicide rate was 21.83 per 100 000 person‐years, and SMR was 1.83 (95% CI: 1.59‐2.10). On Cox regression, diagnosis in early years (1973‐1982 vs 2003‐2015, HR: 2.03, 95% CI: 1.01‐4.11, P = 0.048; 1983‐1992 vs 2003‐2015, HR: 1.99, 95% CI: 1.18‐3.35, P = 0.010), male sex (vs female sex, HR: 4.43, 95% CI: 2.95‐6.65, P < 0.001), unmarried status (vs married status, HR: 2.54, 95% CI: 1.91‐3.38, P < 0.001), non‐black race (white race vs black race, HR: 4.47, 95% CI: 2.09‐9.58, P < 0.001; other races vs black race, HR: 3.01, 95% CI: 1.08‐8.37, P = 0.035), higher histologic grade (grade IV vs grade I, HR: 3.27, 95% CI: 1.50‐7.13, P = 0.003; grade III vs grade I, HR: 2.13, 95% CI: 1.19‐3.81, P = 0.011) and cancer‐directed surgery not performed (vs performed, HR: 2.78, 95% CI: 1.52‐5.11, P < 0.001) were independent risk factors of suicide among kidney cancer patients. Conclusions Diagnosis in early years, male sex, unmarried status, non‐black race, higher histologic grade, and cancer‐directed surgery not performed were significantly associated with suicide among kidney cancer patients. In order to prevent suicidal death, clinicians should pay more attention to patients with high‐risk factors of suicide.

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Section: Discussionsupporting

confidence: 86%

Section: Discussioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Risk factors associated with suicide among kidney cancer patients: A Surveillance, Epidemiology, and End Results analysis

et al. 2019

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“…This is one of the most representative large tumor databases in North America, which covers approximately 28% of the US population 29,30 . SEER has collected information on the incidence, prevalence, mortality, and other evidence‐based medicines of cancer patients in some US states and counties for decades, providing valuable information on cancer diseases for the majority of clinical medical staff 31 . Especially, it provides a broad path for the study of malignant tumors and rare tumors.…”

Section: Medical Public Database Overviewmentioning

confidence: 99%

Brief introduction of medical database and data mining technology in big data era

Yang

Liu

et al. 2020

J Evidence Based Medicine

415

285

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Data mining technology can search for potentially valuable knowledge from a large amount of data, mainly divided into data preparation and data mining, and expression and analysis of results. It is a mature information processing technology and applies database technology. Database technology is a software science that researches manages, and applies databases. The data in the database are processed and analyzed by studying the underlying theory and implementation methods of the structure, storage, design, management, and application of the database. We have introduced several databases and data mining techniques to help a wide range of clinical researchers better understand and apply database technology.

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Risk factors associated with suicide among leukemia patients: A Surveillance, Epidemiology, and End Results analysis

Cai

Huang

et al. 2020

Cancer Medicine

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Previous studies have found that the risk of suicide is higher in patients diagnosed with cancer than in the general population. We aimed to identify potential risk factors associated with suicide in leukemia patients by analyzing data obtained from the Surveillance, Epidemiology, and End Results (SEER) database. We screened the SEER database for leukemia patients added between 1975 and 2017, and calculated their suicide rate and standardized mortality rate (SMR) relative to the total United States population from 1981 to 2017 as a reference. Univariate and multivariate Cox regression analyses were used to determine the risk factors for suicide in leukemia patients. We collected 142,386 leukemia patients who had been added to the SEER database from 1975 to 2017, of whom 191 patients committed suicide over an observation period of 95,397 person‐years. The suicide rate of leukemia patients was 26.41 per 100,000 person‐years, and hence the SMR of the suicided leukemia patients was 2.16 (95% confidence interval [CI] = 1.85–2.47). The univariate and multivariate Cox regression analyses showed that a high risk of suicide was associated with male sex (vs. female: hazard ratio [HR] = 4.41, 95% CI = 2.93–6.63, p < 0.001), older age at diagnosis (60–69 years vs. ≤39 years: HR = 2.60, 95% CI = 1.60–4.23, p < 0.001; 70–79 years vs. ≤39 years: HR = 2.84, 95% CI = 1.72–4.68, p < 0.001; ≥80 years vs. ≤39 years: HR = 2.94, 95% CI = 1.65–5.21, p < 0.001), white race (vs. black: HR = 6.80, 95% CI = 1.69–27.40, p = 0.007), acute myeloid leukemia (vs. lymphocytic leukemia: HR = 1.59, 95% CI = 1.09–2.33, p = 0.016), unspecified and other specified leukemia (vs. lymphocytic leukemia: HR = 2.72, 95% CI = 1.55–4.75, p < 0.001), and living in a small city (vs. large city: HR = 2.10, 95% CI = 1.23–3.60, p = 0.007). Meanwhile, being a non‐Hispanic black (vs. Hispanic: HR = 0.06, 95% CI = 0.01–0.62, p = 0.019) was a protective factor for suicide. Male sex, older age at diagnosis, white race, and acute myeloid leukemia were risk factors for suicide in leukemia patients, while being a non‐Hispanic black was a protective factor. Medical workers should, therefore, provide targeted preventive measures to leukemia patients with a high risk of suicide.

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Trends in incidence and associated risk factors of suicide mortality among breast cancer patients

Abstract: There have been no identifiable improvements in preventing suicide mortality in the United States. Younger age, male sex, race, marital status, and undergoing surgery are independent risk factors for committing suicide, especially in the first year after diagnosis.

Cited by 32 publications

References 36 publications

Risk factors associated with suicide among kidney cancer patients: A Surveillance, Epidemiology, and End Results analysis

Risk factors associated with suicide among kidney cancer patients: A Surveillance, Epidemiology, and End Results analysis

Brief introduction of medical database and data mining technology in big data era

Risk factors associated with suicide among leukemia patients: A Surveillance, Epidemiology, and End Results analysis

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