Trends in <i>Stenotrophomonas maltophilia</i> Bloodstream Infection in Relation to Usage Density of Cephalosporins and Carbapenems During 7 Years

Paez, Jorge G.; Levin, Anna S.; Basso, Matteo; Gomez, Laura B.; Gobara, S.; Spadão, Fernanda; Oshiro, Isabel Cristina Villela Soares; Costa, Sílvia Figueiredo

doi:10.1086/591032

Cited by 4 publications

(3 citation statements)

References 7 publications

(9 reference statements)

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“…This observation highlights the importance of clearly understanding the setting of where each study is performed prior to generalizing its results to other populations. S. maltophilia BSI is usually seen in cancer patients, especially those with haematogenous malignancies, neutropenia, central venous catheters, and those receiving broad-spectrum antimicrobial agents, particularly carbapenems [28–31]. Cancer is much more prevalent in hospitalized patients at large tertiary-care centres that provide care for cancer patients, such as Mayo Medical Center, than in the general population.…”

Section: Discussionmentioning

confidence: 99%

Influence of referral bias on the clinical characteristics of patients with Gram-negative bloodstream infection

2011

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SummaryReferral bias can influence the results of studies performed at tertiary-care centers. In this study, we evaluated demographic and microbiologic factors that influenced referral of patients with gram-negative bloodstream infection (BSI OR=17.94, were overrepresented in the referral cohort. We demonstrated that demographic and microbiologic characteristics of patients with gram-negative BSI had an influence on referral patterns. These factors should be considered when interpreting results of investigations performed at tertiary-care centers.

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Section: Discussionmentioning

confidence: 99%

Influence of referral bias on the clinical characteristics of patients with Gram-negative bloodstream infection

2011

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“…Microbial populations, on the other hand, have evolved a variety of methods to combat these antimicrobial agents, which is a significant factor in the global spread of antimicrobial resistance. Sphingomonas paucimobilis is a common and adaptable human opportunistic pathogen that affects mortality and healthcare costs in both hospitals and the population [8]. Antibiotic resistance tests were conducted on Cefazolin, Ceftazidime, Ceftriaxone, Cefotaxime, Cefepime, Imipenem, Tobramycin, Ciprofloxacin, Levofloxacin, and Trimethoprim from a total of 24 samples of Sphingomonas paucimobilis obtained in Erbil.…”

Section: Antibiotics Susceptibility Tests For Sphingomonas Paucimobilismentioning

confidence: 99%

Sphingomonas Paucimobilis Bacteria Isolation From Different Clinical Samples Of a Nosocomial Infection In Erbil City

Aldilemi¹,

Ali²,

AlSudani³

et al. 2021

Al-Qadisiyah Journal of Pure Science

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Abstract Background: Sphingomonas paucimobilis is a gram-negative pathogen that causes urinary tract infections, diarrhea, septicemia, and wound infections. Due to the spread of patients with high mortality but low mortality in Sphingomonas paucimobilis, it has been isolated from different clinical samples and is increasing antibiotic resistance all over the world. Objectives: The aim of our research was to look at the epidemiology, antibiotic susceptibility series, and pathogenic potential of clinical samples from Erbil's Rizgary and Raparin hospitals. Materials and Methods: A total of 2582 samples were reviewed from different clinical samples from Rizgary Hospital and Raparin Hospital from male and female, we found 24 Sphingomonas paucimobilis isolates, identified by using microscopical, morphological, biochemical tests and Vitek2 compact system according to the standard protocol against Ampicillin/Sulbactam, Cefazolin, Ceftazidime, Ceftriaxone, Cefepime, Imipenem, Tobramycin, Ciprofloxacin, Lev- ofloxacin, Trimethoprim. using Vitek 2 compact system. Results: 24 total positive results of Sphingomonas paucimobilis isolated from 2582 different clinical specimens the highest percentage of Sphingomonas paucimobilis was isolated from female samples (65%) while from male (35%) wen performing antibiotic susceptibility the highest resistance rate was Trimethoprim (66.66%), followed by To bramycin (50%), Ciprofloxacin (50%) and Levofloxacin (41.66%), respectively in contrast the highest effective antibiotic against Sphingomonas paucimobilis was Cefepime (75%), Imipenem (75%), followed by Ceftriaxone (66.66%), Ceftazidime (66.66%), Cefazolin (66.66%), Ampicillin/Sulbactam (66.66%) Conclusion: Morbidity attribute to antibiotic resistance to third generation cephalosporin resistant, Sphingomonas paucimobilis resistant is significant, if prevailing resistance trends continue, high societal and economic costs can be expected. Better management of antibiotic use, and infection control is needed to avoid infections that caused by drug resistant pathogens like Sphingomonas paucimobilis.

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“…RODRIGUES A relação do uso dos betalactâmicos com o aumento da incidência de infecções por S. maltophilia ainda é assunto controverso na literatura. Em um estudo epidemiológico realizado no Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo (HC/FMUSP) no período de 1999 a 2006, com o objetivo de avaliar o efeito do uso de carbapenêmicos e cefalosporinas de quarta ou terceira geração (com ação antipseudomonas) e a associação dessas drogas ao aumento da incidência desse agente em infecções de corrente sanguínea, não foi observado aumento significativo na taxa de incidência (18) .…”

Section: Introductionunclassified

Stenotrophomonas maltophilia: resistência emergente ao SMX-TMP em isolados brasileiros. uma realidade?

Rodrigues

Gioia²,

Rossi³

2011

J. Bras. Patol. Med. Lab.

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Introdução: Stenotrophomonas maltophilia é um importante patógeno hospitalar emergente, naturalmente resistente aos carbapenêmicos, que possui sulfametoxazol/trimetoprima (SMX-TMP) como opção terapêutica. Porém, relatos de resistência a essa droga começaram a aparecer. Objetivos: Avaliar o perfil de sensibilidade das cepas de S. maltophilia e comparar os resultados obtidos por diferentes metodologias. Método: As cepas isoladas na rotina microbiológica do Hospital das Clínicas de São Paulo em 2007 foram avaliadas quanto ao perfil de suscetibilidade por disco-difusão e microdiluição. Respeitando a padronização do Clinical and Laboratory Standard Institute (CLSI), SMX-TMP e levofloxacino foram testados pelas duas técnicas, bem como a tigeciclina, interpretada segundo a agência norte-americana Food and Drug Administration (FDA). Ticarcilina/clavulanato, ceftazidima, imipenem, meropenem e moxifloxacino foram avaliados apenas por microdiluição. O percentual de correlação entre as metodologias foi analisado pelo programa WHONET ® . Resultados: Das 126 cepas, 1,6% apresentaram resistência a SMX-TMP; 2,4%, a levofloxacino; 23%, a ticarcilina/clavulanato; 54%, a ceftazidima. Todas apresentaram concentração inibitória mínima (CIM) < 2 µg/mL para tigeciclina e 96,8%, CIM ≤ 2 µg/mL para moxifloxacino. O índice de concordância categórica entre as metodologias foi de 100% para SMX-TMP e de 89,6% para levofloxacino. Discussão e conclusão: Embora SMX-TMP seja a droga de escolha para o tratamento de infecções por S. maltophilia, há possibilidade de resistência a esse antibiótico, dificultando a decisão terapêutica empírica, sendo fundamental a realização do teste de sensibilidade. A técnica de disco-difusão demonstrou boa correlação com a microdiluição. Entre as novas opções terapêuticas, tigeciclina e moxifloxacino apresentaram boa atividade in vitro. resumo unitermos Stenotrophomonas maltophiliaDisco-difusão Microdiluição Sulfametoxazol/ trimetoprima abstract Introduction: Stenotrophomonas maltophilia is an important emerging nosocomial pathogen naturally resistant to carbapenems. Although trimethoprim/sulfamethoxazole (TMP-SMX) is commonly used as a treatment option, resistance to this drug has been recently reported. Objectives: To evaluate the susceptibility profile of S. maltophilia strains and compare the results obtained by different methods. Methods: As to susceptibility profile, all strains, which had been routinely isolated at Hospital das Clínicas, São Paulo, in 2007, were evaluated through disk diffusion and microdilution. In accordance with the Clinical and Laboratory Standard Institute (CLSI), TMP-SMX and levofloxacin were tested through both techniques, as well as tigecycline, which was interpreted in conformity with Food and Drug Administration (FDA) regulations. Ticarcillin/clavulanate, ceftazidime, imipenem, meropenem and moxifloxacin were evaluated only through microdilution. The correlation between these methods was assessed by WHONET ® . Results: 1.6% of 126 strains were resistant to TMP-SMX, 2.4% to levoflo...

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Trends in Stenotrophomonas maltophilia Bloodstream Infection in Relation to Usage Density of Cephalosporins and Carbapenems During 7 Years

Cited by 4 publications

References 7 publications

Influence of referral bias on the clinical characteristics of patients with Gram-negative bloodstream infection

Influence of referral bias on the clinical characteristics of patients with Gram-negative bloodstream infection

Sphingomonas Paucimobilis Bacteria Isolation From Different Clinical Samples Of a Nosocomial Infection In Erbil City

Stenotrophomonas maltophilia: resistência emergente ao SMX-TMP em isolados brasileiros. uma realidade?

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