Trends in heart failure incidence and survival in a community-based population

Roger, VÃ©ronique L.; Weston, Susan A.; Redfield, M. M.

doi:10.1016/j.accreview.2004.11.055

Cited by 339 publications

(479 citation statements)

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“…Despite the poor prognosis, the incidence of CHF from 1950 to 2000 has not changed drastically (6,7). Randomized controlled trials between 1986 and 1997 found that CAD was the main etiology (found in 70% of cases) leading to CHF (3 …”

Section: Discussionmentioning

confidence: 99%

Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy

Luk

Metawee

Ahn

et al. 2009

Canadian Journal of Cardiology

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BACkGRounD: Heart transplantation remains the last treatment option for patients with end-stage cardiac disease. Such diseases include ischemic cardiomyopathy, nonischemic cardiomyopathy and other conditions such as arrhythmogenic right ventricular dysplasia, cardiac sarcoidosis and cardiac amyloidosis. oBJECTivE: To review the changes that have occurred over time in the etiology of heart disease in patients requiring heart transplantation, and to compare the clinical and histological diagnoses of explanted hearts from patients with progressive cardiac disease.

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Section: Discussionmentioning

confidence: 99%

Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy

Luk

Metawee

Ahn

et al. 2009

Canadian Journal of Cardiology

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“…HF is a complex clinical syndrome and it is the final and most severe manifestation of nearly every form of heart disease (4,5). The prognosis of HF is particularly poor, with fewer than 50% of subjects remaining alive by 5 years, and only 10% by 10 years following the initial diagnosis (14)(15)(16)(17). Likewise, we recently found that HF is an important contributor to the excess overall mortality in RA (Crow- …”

Section: Discussionmentioning

confidence: 99%

How much of the increased incidence of heart failure in rheumatoid arthritis is attributable to traditional cardiovascular risk factors and ischemic heart disease?

Crowson¹,

Nicola²,

Kremers³

et al. 2005

Arthritis & Rheumatism

144

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Objective. To compare the proportion of the risk for the development of heart failure (HF) that is attributable to traditional cardiovascular (CV) risk factors, ischemic heart disease (IHD), and alcohol abuse between subjects with and subjects without rheumatoid arthritis (RA).Methods. A population-based inception cohort of RA patients was assembled along with a similar cohort of subjects without RA. All individuals were followed up through their complete medical records, until HF incidence, death, migration, or January 1, 2001. The attributable risk of HF was estimated as the difference between the observed cumulative incidence of HF in each cohort (estimated from multivariable Cox models and adjusted for the competing risk of death) and the predicted cumulative incidence of HF in the absence of risk factors, with results expressed as a percentage of the observed cumulative incidence.Results. A total of 575 RA subjects and 583 non-RA subjects (mean age 57 years, 73% women) without HF at incidence/index date had a mean followup of 15.1 and 17.0 years, respectively. During that period, 165 RA and 115 non-RA subjects had a first episode of HF, with a cumulative incidence of 36.3% and 20.4%, respectively, at age 80 years. Among non-RA subjects, 77% of the HF at age 80 years was attributable to CV risk factors, IHD, and alcohol abuse combined, whereas among RA subjects, only 54% of the HF at age 80 years was attributable to these factors (P < 0.01). Conclusion. The excess risk of HF among RA patients is not explained by an increased frequency or effect of CV risk factors and IHD.Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease of unknown etiology, affecting ϳ1% of the adult general population (1,2). Patients with RA have twice the risk of heart failure (HF) when compared with individuals of the same age and sex without RA (3). The mechanism behind this increased risk is unknown. The etiology of HF can be multifactorial, with several clinical risk factors coexisting and interacting to produce this clinical syndrome (4,5). Ischemic heart disease (IHD) and hypertension have long been recognized as major risk factors for HF in the general population (6-9). Therefore, elimination of traditional cardiovascular (CV) risk factors and IHD is a recognized approach to prevent HF (9).However, we previously reported that the increased risk of HF in subjects with RA appears to be independent of the presence or effect of IHD and CV risk factors (3). Consequently, IHD and CV risk factors may play a different role with respect to the development and prevention of HF in RA subjects, compared with non-RA subjects. The aim of the present study was to compare the proportion of the risk for the development of HF that is attributable to traditional CV risk factors, IHD, and alcohol abuse between subjects with and subjects without RA.

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“…9 In addition, clinical outcomes among women with HF have not improved at the same rate as those seen in men. 10 It is unclear whether this is due to sex-related differences in pathophysiology, disparities in the application of evidence-based HF therapies, or a difference in response to treatment.…”

Section: Epidemiologymentioning

confidence: 99%

Heart Failure in Women

Shin

Hamad

Murthy

et al. 2012

Clinical Cardiology

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Heart failure (HF) has steadily increased in prevalence and affects both males and females equally. Despite this, there has been a significant underrepresentation of women in large scale HF trials. This disparity has lead to a deficit in understanding important gender-based differences in pathophysiology, diagnosis and treatment strategies. We review these gaps and explore a biological basis for varying outcomes. Endogenous estrogen plays an important role in epidemiology and outcome. The administration of exogenous estrogen has had varied success in treatment and is outlined extensively below. Additionally, we highlight unique HF syndromes through pregnancy and important sex-specific issues concerning transplant and mechanical circulatory support. A central theme remains: there is a clear need for increased female recruitment in clinical trials, and more studies exploring the role of gender-based biology in HF treatment. IntroductionThe prevalence of heart failure (HF) has steadily increased and is now the leading cause of hospital admissions in the adult population in the United States. 1 Women constitute approximately one half of the patients hospitalized for HF, and deaths from HF contribute 35% of the total cardiovascular disease (CVD) mortality in women. 1 -3 Despite this, women have been historically under-represented in clinical HF trials. Although the population estimate of women among patients with HF in the Unites States is about 50%, only 17% to 23% of HF randomized controlled trials enrolled women. 4 This disparity has limited our understanding of gender-related differences in HF. The objective of this article is to review the relationships between sex and the epidemiology, etiology, clinical characteristics, therapeutic management, and outcomes in patients with HF.

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Trends in heart failure incidence and survival in a community-based population

Cited by 339 publications

References 0 publications

Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy

Do clinical diagnoses correlate with pathological diagnoses in cardiac transplant patients? The importance of endomyocardial biopsy

How much of the increased incidence of heart failure in rheumatoid arthritis is attributable to traditional cardiovascular risk factors and ischemic heart disease?

Heart Failure in Women

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