The effect of left ventricular volume (LVV) in relation to the left ventricular mass (LVM) was studied on the voltage electrocardiographic (ECG) criteria of left ventricular hypertrophy (LVH).
IntroductionIt is well recognized that there are numerous physiological and pathological factors that affect ECG criteria for left ventricular hypertrophy (LVH) [1]. In 1960, Allenstein and Mori evaluated ECG criteria that were introduced for the diagnosis of LVH and they noticed that the literature at that time included over 30 ECG criteria [2]. However, in clinical practice, voltage criteria are the most commonly used despite the evidence that voltage ECG-LVH criteria are influenced by many factors that might commonly co-exist with LVH. For example, there is evidence that increased left ventricular volume (LVV) might potentiate the QRS voltages [3,4]. Therefore, it might be expected that the ECG-LVH voltage criteria would be more positive in LVH with LV dilatation than in LVH with normal LVV.
MethodsConsecutive patients attending the echocardiography laboratory in Glasgow Royal Infirmary were recruited to the study provided that they had documented echo LVH in the absence of hypertrophic obstructive cardiomyopathy, bundle branch block, pericardial disease, kyphoscoliosis or emphysema, or history of myocardial infarction.The ECGs were recorded by a Siemens Mingorec 4 or by a computer compatible electrocardiograph designed locally [5]. The amplitudes of the QRS voltages were measured by a computer program described elsewhere [6]. All the amplitudes were also checked manually and were compared to age and sex dependent normal limits that were derived from an earlier study from our department [7]. The sensitivity of the following ECG-LVH voltage criteria was assessed in the twogroupsofechoLVH: The echocardiographic examinations were undertaken with a Diasonics 3400 Cardiovue phased imaging system as described in a previous study [11]. The M-mode echo dimensions of the left ventricle (LV) were used to calculate left ventricular mass (LVM) according to the Penn convention [12] but left ventricular volume (LVV) was estimated using the equation of Pombo et al [13]. Both the derived echo LVM and LVV were indexed to body surface area (BSA) according to the formula of DuBois and DuBois [14]. Patients with echo LVH were defined by echo LVM indexed to BSA exceeding 131 g/m 2 in men and 109g/m 2 in women [15]. LVV indexed to BSA (LVVI) exceeding 90 ml/m 2 identified those patients with LVH and LV dilatation [13]. Based on one of our earlier studies [11], concentric LVH was defined as increased LVM indexed to BSA in the presence of a normal or even reduced LVV (indexed to BSA), while patients with eccentric LVH were identified when LVH was associated with left ventricular dilatation.
Results36 patients completed the study including 25 men and 11 women. They had a mean age of 54.6 years and an age range of 30-72 years. The underlying pathological conditions included hypertension in 28 patients and 0276−6547/03 $17.00