Trends in drug-resistant tuberculosis after the implementation of the DOTS strategy in Shenzhen, China, 2000–2013

Zhu, Lijun; Yz, Yang; Guan, H-Y; Cheng, Saifeng; Jin, Y-Y; Tan, W-G; Wu, Qiaofeng; Xl, Liu; Zhao, M-G; Zh, LU; Jia, Zheng

doi:10.5588/ijtld.16.0759

Cited by 8 publications

(11 citation statements)

References 1 publication

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, the study population is representative of most TB patients in Shenzhen City, because about 50% of all cases under DOTS came from the study site. The re-treatment rate in our study was 5.84%, which is similar to that reported in other studies, with a re-treatment rate of 6.7% in Shenzhen [36] and 6.4% in other provinces in China [37]. This indicates that our study was acceptably representative of the treatment conditions for TB patients in Shenzhen specifically and China generally.…”

Section: Strengths and Limitationssupporting

confidence: 90%

Analysis of the economic burden of diagnosis and treatment on patients with tuberculosis in Bao’an district of Shenzhen City, China

Huang

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

Background Illness-related costs experienced by tuberculosis patients produce a severe economic impact on households, especially poor families. Few studies have investigated the full costs, including direct and indirect costs, at the patient and household levels in southeast China. Methods A case follow-up study was conducted in the Bao'an district of Shenzhen City, China. Eligible new and previously treated individuals with pulmonary tuberculosis (TB) during January 1 st 2013 to June 30 th 2013 were enrolled. Medical and non-medical costs as well as income loss were calculated in diagnosis and treatment periods, respectively. Factors associated with costs due to TB diagnosis, treatment and TB care (diagnosis + treatment) were explored respectively with a linear regression model. Results Of the total 514 TB patients enrolled, 95% were from the migrant population, and 65% were males, with a mean age of 32.25 (±10.11). The median costs due to TB diagnosis and TB treatment were 79 United States dollar (USD), 748USD (6.2897 China Yuan (CNY) = 1USD, 2013) per patient, respectively. The median costs due to TB care (diagnosis and treatment) per patient was 1218USD, corresponding to 26% of patients' annual income preillness. Those who visited more times to health facilities, hospitalized, received higher education, or occupied in national civil servant/services/retired staff might expense more before diagnosis. Costs due to TB treatment was significantly higher among migrant patients, sputum smear positive patients, and widowed/divorced population. Factors associated with less total costs were native patients, fewer times of visiting to health-care facilities and those with no hospitalization history due to TB.

show abstract

Section: Strengths and Limitationssupporting

confidence: 90%

Analysis of the economic burden of diagnosis and treatment on patients with tuberculosis in Bao’an district of Shenzhen City, China

Huang

et al. 2020

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Given that RIF has been the most widely used antimicrobial agent against M. tuberculosis for decades, identification of RIF resistance trends among M. tuberculosis isolates should help us better guide clinical interventions involving this potent agent. Although some studies have compared the prevalences of RIF resistance using conventional drug susceptibility testing in China (19)(20)(21), a comparative analysis of the RIF MIC distribution has not yet been reported. In this study, we assessed the trend of RIF resistance from 2005 to 2015 in M. tuberculosis isolates chosen at random from the repository of the National Clinical Center on Tuberculosis in China.…”

mentioning

confidence: 99%

A 10-Year Comparative Analysis Shows that Increasing Prevalence of Rifampin-Resistant Mycobacterium tuberculosis in China Is Associated with the Transmission of Strains Harboring Compensatory Mutations

Huo

Luo

Shi

et al. 2018

Antimicrob Agents Chemother

View full text Add to dashboard Cite

In this work, we conducted bacterial population profile studies to assess trends of rifampin (RIF) resistance of isolates collected across China from 2005 to 2015. Totals of 273 and 269 randomly selected isolates from 2005 and 2015, respectively, were analyzed. The rates of RIF resistance (36.4%), isoniazid resistance (39.0%), and levofloxacin resistance (25.7%) in 2015 were significantly higher than those in 2005 (28.2%, 30.0%, and 15.4%, respectively; < 0.05). Genotypic data revealed 256 (95.2%) Beijing-type isolates in 2015, a rate significantly higher than that in 2005 (86.4%) ( < 0.01). A higher proportion of mutations was identified within the rifampin resistance-determining region (RRDR) of in isolates from 2015 (99.0%) than in 2005 isolates (85.7%, < 0.01). In addition, a significantly higher proportion of RIF-resistant isolates carrying compensatory mutations was observed in 2015 (31.6%) than in 2005 (7.8%). Notably, the great majority of these compensatory mutations (91.9%) were observed in isolates that harbored a mutation of codon 531 of the gene. In conclusion, our data demonstrate that resistance to RIF, isoniazid, and levofloxacin has become significantly more prevalent during the past decade. In addition, the prevalence of the Beijing genotype significantly increased from 2005 to 2015. Notably, a significantly increased frequency of strains with mutations in or is observed among those that have codon 531 mutations, which suggests that they may be compensatory and may play a role in facilitating transmission.

show abstract

“…22 Early detection, regulation of treatment and management of tuberculosis patients are the key to controlling the spread of tuberculosis, and can also effectively prevent the emergence of drug-resistant tuberculosis. 23 With the expansion of directly observed treatment and short course chemotherapy (DOTs) during tuberculosis control strategy in recent years, 24 China has paid more and more attention to the tuberculosis cases of the floating population and integrated the prevention and treatment of tuberculosis into the comprehensive management of community health. The total transferred in place rate in Shaanxi province was 79.7%, which is Higher than Hubei, 25 Shenzhen, 11 but slightly lower than Fujian.…”

Section: Discussionmentioning

confidence: 99%

Tuberculosis cases in cross-regional floating population from 2009 to 2017 in Shaanxi Province, China

Men

Zhang

Liu

et al. 2020

Preprint

View full text Add to dashboard Cite

Background : The cross-regional population of tuberculosis (TB) has become an important part of the prevention and control of TB cases in China with the gradually increasing of floating population. The aim of our study was to explore the main epidemiological characteristics and provide reference for the treatment and management of TB cases in cross-regional floating population in Shaanxi Province. Methods: The data of TB cases in cross-regional floating population from 2009 to 2017 were derived from the National Tuberculosis Management Information Registration System. Descriptive analysis was applied for the baseline demographical, continuous data are expressed as means ± standard deviation and categorical in percentage. The χ2 test, which was implemented as Fisher’s exact test in this study, was applied to categorical variable comparisons. Results: A total of 613 floating TB cases consisting of 413 males (67.4%) and 200 females (32.6%) were registered in Shaanxi province from 2009 to 2017. The difference of gender distribution was statistically significant ( P =0.039). Of the total, 190 cases (31.0%) were smear-positive and 175 cases (28.5%) were negative. From 2009 to 2017, the difference of the gender distribution was not statistically significant ( P =0.732), but the difference in the rate of transferred into original was found statistically significant ( P =0.000). Conclusion: The number of TB cases in cross-regional floating population in Shaanxi Province showed a relatively stable trend from 2009 to 2017. Young males should be given more attentions in TB control because they counted most of the TB cases.

show abstract

Trends in drug-resistant tuberculosis after the implementation of the DOTS strategy in Shenzhen, China, 2000–2013

Cited by 8 publications

References 1 publication

Analysis of the economic burden of diagnosis and treatment on patients with tuberculosis in Bao’an district of Shenzhen City, China

Analysis of the economic burden of diagnosis and treatment on patients with tuberculosis in Bao’an district of Shenzhen City, China

A 10-Year Comparative Analysis Shows that Increasing Prevalence of Rifampin-Resistant Mycobacterium tuberculosis in China Is Associated with the Transmission of Strains Harboring Compensatory Mutations

Tuberculosis cases in cross-regional floating population from 2009 to 2017 in Shaanxi Province, China

Contact Info

Product

Resources

About