Trends in Disparate Treatment of African American Men With Localized Prostate Cancer Across National Comprehensive Cancer Network Risk Groups

Mahal, Brandon A.; Aizer, Ayal A.; Ziehr, David R.; Hyatt, Andrew S.; Sammon, Jesse D.; Schmid, Marianne; Choueiri, Toni K.; Hu, Jim C.; Sweeney, Christopher J.; Beard, Clair J.; D’Amico, Anthony V.; Martin, Neil E.; Kim, Simon P.; Trinh, Quoc Dien; Nguyen, Paul L.

doi:10.1016/j.urology.2014.05.009

Cited by 89 publications

(63 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…For mortality this may be due in part to the elevated breast and prostate cancer rates among black populations in the sub-region, combined with outcome disparities and an increased risk of death for both cancers, as reported in other settings. [14][15][16][17][18][19] Lung cancer was the first cause of death in two of the sub-regions but warrants cautious interpretation on considering the relatively low rates of lung cancer incidence and the fact that mortality should closely follow incidence given the consistently poor prognosis from this cancer. The underlying inferior quality of death certificates cannot be excluded as a possible explanatory artefact.…”

Section: 23mentioning

confidence: 99%

Cancer patterns, trends and projections in Latin America and the Caribbean: a global context

Bray¹,

Piñeros²

2016

Salud Publica Mex

117

View full text Add to dashboard Cite

Objective. To develop a situation analysis encompassing the patterns and trends in cancer incidence and mortality in South and Central America and the Caribbean, with comparisons globally and with selected external countries. Materials and methods. Data on cancer incidence and mortality rates for 31 countries were obtained from the 2012 GLOBOCAN database. Incidence and mortality trends for selected countries were analysed with data from the Cancer Incidence in Five Continents (CI5) series and the WHO Mortality Database, respectively. Results. In 2012, almost 1.1 million new cancer cases were estimated annually, with important variations in rates across countries. The most common cancer types were breast, prostate, colorectum and lung cancer; stomach and cervical cancer ranked high in less developed countries. Increasing trends were observed in prostate, breast and colorectal cancer; lung cancer mortality trends diverged among males and females, while cervix cancer incidence and stomach cancer mortality uniformly decreased. A 66% increase in cancer cases in the region by 2030 is projected based on population aging and growth. Conclusions. Cancer patterns and trends reflect the significant sociodemographic changes in the region: the growing burden imposes great challenges to national health care systems to implement cancer control actions, while improving cancer surveillance to effectively measure the response.Keywords: cancer; mortality; incidence; Latin America ResumenObjetivo. Analizar la situación y tendencias en la incidencia y mortalidad por cáncer en América del Sur, Central y el Caribe, en comparación con patrones mundiales. Material y métodos. Los datos de incidencia y mortalidad por cáncer de 31 países se obtuvieron de la base de datos de GLOBOCAN 2012. Para analizar las tendencias de incidencia y mortalidad en países seleccionados, los datos se obtuvieron de la serie Incidencia de Cáncer en Cinco Continentes (CI5) y de la base de datos de mortalidad de la OMS, respectivamente. Resultados. En 2012, se estimaron casi 1.1 millones de nuevos casos de cáncer al año, con variaciones importantes en las tasas entre los distintos países. Los tipos de cáncer más comunes fueron cáncer de mama, próstata, colon y recto, y de pulmón; los cánceres de estómago y cuello uterino ocuparon puestos altos en los países menos desarrollados. Se observaron tendencias crecientes en cáncer de próstata, mama y colorrectal; las tendencias de mortalidad por cáncer de pulmón presentaron tendencias divergentes entre hombres y mujeres, mientras que la incidencia de cáncer de cuello uterino y la mortalidad por cáncer de estómago disminuyeron. Para el año 2030 se espera un incremento del 66% en los casos de cáncer. Conclusiones. Los patrones y tendencias del cáncer reflejan los importantes cambios sociodemográficos en la región e imponen grandes desafíos a los sistemas de salud para responder a la creciente carga, así como para mejorar la vigilancia del cáncer.

show abstract

Section: 23mentioning

confidence: 99%

Cancer patterns, trends and projections in Latin America and the Caribbean: a global context

Bray¹,

Piñeros²

2016

Salud Publica Mex

117

View full text Add to dashboard Cite

show abstract

“…A volume of literature exists describing disparities in prostate cancer care, with research detailing that men of African origin are less likely to receive definitive or adjuvant therapy for treatment of prostate cancer 30 , and are more likely to receive primary androgen deprivation therapy (ADT) [75][76][77][78] . Among African-American men receiving definitive therapy, radiation is more common than surgery 75,76,79 , and in those who undergo surgery, differences in surgical quality, oncological outcomes, and quality of life have emerged [80][81][82][83][84][85] .…”

Section: Treatment Selectionmentioning

confidence: 99%

“…Among African-American men receiving definitive therapy, radiation is more common than surgery 75,76,79 , and in those who undergo surgery, differences in surgical quality, oncological outcomes, and quality of life have emerged [80][81][82][83][84][85] . Generally, differences in biology might contribute to a later stage of disease at presentation resulting in poorer outcomes, but the contribution of the availability of early diagnosis and treatment to this disparity remains to be defined.…”

Section: Treatment Selectionmentioning

confidence: 99%

Prostate cancer in men of African origin

2015

View full text Add to dashboard Cite

Men of African origin are disproportionately affected by prostate cancer: prostate cancer incidence is highest among men of African origin in the USA, prostate cancer mortality is highest among men of African origin in the Caribbean, and tumour stage and grade at diagnosis are highest among men in sub-Saharan Africa. Socioeconomic, educational, cultural, and genetic factors, as well as variations in care delivery and treatment selection, contribute to this cancer disparity. Emerging data on single-nucleotide-polymorphism patterns, epigenetic changes, and variations in fusion-gene products among men of African origin add to the understanding of genetic differences underlying this disease. On the diagnosis of prostate cancer, when all treatment options are available, men of African origin are more likely to choose radiation therapy or to receive no definitive treatment than white men. Among men of African origin undergoing surgery, increased rates of biochemical recurrence have been identified. Understanding differences in the cancer-survivorship experience and quality-of-life outcomes among men of African origin are critical to appropriately counsel patients and improve cultural sensitivity. Efforts to curtail prostate cancer screening will likely affect men of African origin disproportionately and widen the racial disparity of disease.

show abstract

“…Based on SEER data, African-American patients were less likely to receive curative-intent therapy (adjusted odds ratio 0.82, 95 % confidence interval 0.79-0.86), especially among patients with NCCN high-risk disease (adjusted odds ratio 0.60, 95 % confidence interval 0.56-0.64) [20]. Filipino men were also less likely to receive definitive treatment in localized prostate cancer in a SEER study of Asian-Americans [21].…”

Section: Evidence Of Radiation Therapy Delivery Disparities In Non-hnmentioning

confidence: 99%

“…Filipino men were also less likely to receive definitive treatment in localized prostate cancer in a SEER study of Asian-Americans [21]. Among patients receiving definitive therapy, AfricanAmerican men are more likely to receive radiation therapy but less likely to undergo surgery [20,22].…”

Section: Evidence Of Radiation Therapy Delivery Disparities In Non-hnmentioning

confidence: 99%

Disparities in radiation therapy delivery: current evidence and future directions in head and neck cancer

Park

Decker

2016

Cancers Head Neck

View full text Add to dashboard Cite

Background: Though treatments for head and neck cancer have improved in recent years, significant variation persists in the delivery of surgery, radiation therapy, and systemic therapy to patients throughout the United States. Body: In this review, we explore the current evidence regarding radiation therapy utilization inequities across the spectra of race, socioeconomic status, and age. We also discuss hypothesized mechanisms for how non-clinical factors may influence shared clinical decisions between patients and providers. Finally, we suggest future directions for research in treatment disparities. Conclusions: Radiation therapy continues to be delivered inequitably among certain subpopulations with head and neck cancer and other cancers. More research into the drivers of these disparities and interventions designed to address them are necessary.

show abstract

Trends in Disparate Treatment of African American Men With Localized Prostate Cancer Across National Comprehensive Cancer Network Risk Groups

Cited by 89 publications

References 21 publications

Cancer patterns, trends and projections in Latin America and the Caribbean: a global context

Cancer patterns, trends and projections in Latin America and the Caribbean: a global context

Prostate cancer in men of African origin

Disparities in radiation therapy delivery: current evidence and future directions in head and neck cancer

Contact Info

Product

Resources

About