Trends in characteristics of surgically treated early gastric cancer patients after the introduction of gastric cancer treatment guidelines in Japan

Tanaka, Norimitsu; Katai, Hitoshi; Taniguchi, Hirokazu; Saka, Makoto; Morita, Shinji; Fukagawa, Takeo; Gotoda, Takuji

doi:10.1007/s10120-009-0536-5

Cited by 13 publications

(11 citation statements)

References 21 publications

(19 reference statements)

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“…Many Japanese series have consistently reported that early diagnosis and treatment of GC, with a 5-year survival rate approximately 90% (29). However, the diagnosis of gastrointestinal (GI) endoscopy cannot find all precancerous diseases and the early stages GC (30).…”

Section: Discussionmentioning

confidence: 99%

Integrated analysis of long non-coding RNA competing interactions reveals the potential role in progression of human gastric cancer

Liang

Yao

et al. 2016

International Journal of Oncology

110

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Abstract. Abnormal expression of long non-coding RNAs (lncRNAs) have been shown to play an important role in tumor biology. The Cancer Genome Atlas (TCGA) platform is a large sample sequencing database of lncRNAs, and further analysis of the associations between these data and patients' clinical related information can provide new approaches to find the functions of lncRNA. In the present study, 361 RNA sequencing profiles of gastric cancer (GC) patients were selected from TCGA. Then, we constructed the lncRNA-miRNA-mRNA competitive endogenous RNA (ceRNA) network of GC. There were 25 GC specific lncRNAs (fold change >2, p<0.05) identified, 19 of them were included in ceRNA network. Subsequently, we selected these 19 key lncRNAs and analyzed the correlations with clinical features and overall survival, 14 of them were discriminatively expressed with tumor size, tumor grade, TNM stage and lymphatic metastasis (p<0.05). In addition, eight lncRNAs (RPLP0P2, FOXD2-AS1, H19, TINCR, SLC26A4-AS1, SMIM10L2A, SMIM10L2B and SNORD116-4) were found to be significantly associated with overall survival (log-rank p<0.05). Finally, two key lncRNAs HOTAIR and UCA1 were selected for validation of their expression levels in 82 newly diagnosed GC patients by qRT-PCR. Results showed that the fold changes between TCGA and qRT-PCR were 100% in agreement. In addition, we also found that HOTAIR was significantly correlated with tumor size and lymphatic metastasis (p<0.05), and UCA1 was significantly correlated with tumor size, TNM stage and lymphatic metastasis (p<0.05).The clinical relevance of the two lncRNAs and the bioinformatics analysis results were almost the same. Overall, our study showed the GC specific lncRNAs expression patterns and a ceRNA network in GC. Clinical features related to GC specific lncRNAs also suggested these lncRNAs are worthwhile for further study as novel candidate biomarkers for the clinical diagnosis of GC and potential indicators for prognosis. IntroductionNoncoding RNAs (ncRNAs) are transcripts that have no ability of coding proteins, which widely exit in high eukaryotics. According to their characteristics, ncRNAs can be divided into several subtypes including transfer RNA, small nucleolar RNA (snoRNA), ribosomal RNA (rRNA), microRNA (miRNA) and long non-coding RNA (lncRNA). The amount of the ncRNAs transcripts is >98% of the whole genome transcripts and have been suggested to represent transcriptional noise (1). However, more and more evidence indicates that transcriptional output of genome is far more complex than predicted, and suggests new paradigms of ncRNA regulation (2).Recent studies suggest that the ncRNAs may play important biological roles in transcriptional regulation, cellular development, formation of chromosome and RNA modification (3). Based on the transcript size, ncRNAs are grouped into small ncRNAs (<200 bp) and long ncRNAs (>200 bp, up to 100 kb). lncRNA is the functional end-product, and the level of lncRNA expression correlates directly with the level of the active molecule. Thus, ...

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Section: Discussionmentioning

confidence: 99%

Integrated analysis of long non-coding RNA competing interactions reveals the potential role in progression of human gastric cancer

Liang

Yao

et al. 2016

International Journal of Oncology

110

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“…If the diagnostic histopathological findings confirm a submucosal carcinoma (T1b) after ER, surgical resection that includes systematic lymphadenectomy has to be performed, because database findings indicate lymph node involvement in up to 20 % of these patients. The earlier established ''extended criteria'' for ER can only be used in the context of studies, since these need expertise, most likely present in high-volume centers [21][22][23][24]. ER of early gastric cancer should be performed as a complete enbloc resection, which allows a complete histological evaluation of the lateral and basal margins.…”

Section: Endoscopic Resectionmentioning

confidence: 99%

International comparison of the German evidence-based S3-guidelines on the diagnosis and multimodal treatment of early and locally advanced gastric cancer, including adenocarcinoma of the lower esophagus

et al. 2014

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Background Clinical guidelines are essential in implementing and maintaining nationwide stage-specific diagnostic and therapeutic standards. In 2011, the first German expert consensus guideline defined the evidence for diagnosis and treatment of early and locally advanced esophagogastric cancers. Here, we compare this guideline with other national guidelines as well as current literature.Methods The German S3-guideline used an approved development process with de novo literature research, international guideline adaptation, or good clinical practice. Other recent evidence-based national guidelines and current references were compared with German recommendations.

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“…Many Japanese series have consistently reported early diagnosis and treatment of GC, with a 5-year survival rate >90%. The key factor for preventing GC is early diagnosis, as confirmed by the good results obtained in surgical series in which early cases are frequent (3). Recent developments in the field of gastrointestinal (GI) endoscopy have been remarkable (4).…”

Section: Introductionmentioning

confidence: 99%

Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer

Liang

Yao

et al. 2015

Oncology Reports

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Gastric cancer (GC) is one of the most lethal malignancies worldwide. To reduce its high mortality, sensitive and specific biomarkers for early detection are urgently needed. Recent studies have reported that tumor-specific long non-coding RNAs (lncRNAs) seem to be potential biomarkers for the early diagnosis and treatment of cancer. In the present study, lncRNA and mRNA expression profiling of GC specimens and their paired adjacent non-cancerous tissues was performed. Differentially expressed lncRNAs and mRNAs were identified through microarray analysis. The function of differential mRNA was determined by gene ontology and pathway analysis and the functions of lncRNAs were studied by constructing a co-expression network to find the relationships with corresponding mRNAs. We connected the co-expression network, mRNA functions, and the results of the microarray profile differential expression and selected 14 significantly differentially expressed key lncRNAs and 21 key mRNAs. Quantitative RT-PCR (qRT-PCR) was conducted to verify these key RNAs in 50 newly diagnosed GC patients. The data showed that RP5-919F19, CTD-2541M15 and UCA1 was significantly higher expressed. AP000459, LOC101928316, RP11-167N4 and LINC01071 expression was significantly lower in 30 advanced GC tumor tissues than adjacent non-tumor tissues P<0.05. Then, we further validated the above significant differential expression candidate lncRNAs in 20 early stage GC patients. Results showed that CTD-2541M15 and UCA1 were significantly higher expressed, AP000459, LINC01071 and MEG3 expression was significantly lower in 20 early stage GC patient tumor tissues than adjacent non-tumor tissues (P<0.05). In addition, expression of these lncRNAs shows gradual upward trend from early stage GC to advanced GC. Furthermore, conditional logistic regression analysis revealed the aberrant expression of CTD-2541M15, UCA1 and MEG3 closely linked with GC. There is a set of differentially expressed lncRNAs in GC which may be associated with the progression and development of GC. The differential expression profiles of lncRNAs in GC may be promising biomarkers for the early detection and early screening of high‑risk populations.

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Trends in characteristics of surgically treated early gastric cancer patients after the introduction of gastric cancer treatment guidelines in Japan

Cited by 13 publications

References 21 publications

Integrated analysis of long non-coding RNA competing interactions reveals the potential role in progression of human gastric cancer

Integrated analysis of long non-coding RNA competing interactions reveals the potential role in progression of human gastric cancer

International comparison of the German evidence-based S3-guidelines on the diagnosis and multimodal treatment of early and locally advanced gastric cancer, including adenocarcinoma of the lower esophagus

Differential expression profiles of long non-coding RNAs reveal potential biomarkers for identification of human gastric cancer

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