Trends in cancer of the urinary bladder and urinary tract in elderly in Denmark, 2008–2012

Jensen, Thor; Jensen, Niels Viggo; Jørgensen, Simon Møller; Clark, Peter E.; Lund, Lars

doi:10.3109/0284186x.2015.1115122

Cited by 8 publications

(2 citation statements)

References 26 publications

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“…The majority of new cases affect male patients aged 65 yr and older, and mortality increases with age. Advanced age appears to be the greatest overall risk factor for developing bladder cancer, with a seven- to 10-fold increase in the risk observed in those >70 yr old [3] , [4] , [5] .…”

Section: Introductionmentioning

confidence: 99%

Living with Bladder Cancer: Self-reported Changes in Patients’ Functional and Overall Health Status Following Diagnosis

Ungerer

Anwar

Golzy

et al. 2020

European Urology Open Science

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Background Bladder cancer affects life quality, overall health, and mortality negatively. The effect of bladder cancer on activities of daily living (ADLs) is not well established. Objective To examine the effect of bladder cancer diagnosis on ADLs, in addition to physical, mental, and overall health measures. Design, setting, and participants Using data from the Surveillance, Epidemiology, and End Results (SEER)-Medicare Health Outcomes Survey (MHOS) registry, responses regarding ADLs and overall health were evaluated in bladder cancer patients over time. The Short Form 12 health survey responses were analyzed to determine the change in physical and mental health scores following bladder cancer diagnosis. Outcome measurements and statistical analysis Changes in self-reported ability to perform ADLs and health outcomes following bladder cancer diagnosis were evaluated. Chi-square statistics were used to determine whether the baseline and follow-up surveys were statistically independent for each ADL. Composites scores for physical health (PCS12) and mental health (MCS12) were compared with two-sample t test. Results and limitations A total of 498 patients with surveys before and after bladder cancer diagnosis were identified. An increased percentage of patients reported difficulty in all ADL tasks following bladder cancer diagnosis; this increase was statistically significant for bathing ( p = 0.02) and using the toilet ( p = 0.03). These patients also reported a significant decline in overall health status ( p = 0.0002). A significant reduction in the mean PCS12 and mean MCS12 composite scores was observed ( p < 0.0001 and p = 0.0003, respectively). Conclusions Patients with bladder cancer report a significant decline in functional status and overall health, including both physical and mental well-being after diagnosis. Further study is needed for factors that may be most predictive of the decline in functional independence for this population. Patient summary There is a decreased ability to perform daily activities following bladder cancer diagnosis, and patients report a decrease in their physical and mental health. This information can help patients and their caregivers anticipate patient needs following bladder cancer diagnosis, in addition to helping manage their expectations when making decisions regarding treatment options.

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Section: Introductionmentioning

confidence: 99%

Living with Bladder Cancer: Self-reported Changes in Patients’ Functional and Overall Health Status Following Diagnosis

Ungerer

Anwar

Golzy

et al. 2020

European Urology Open Science

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“…1 UBC is known to have an inferior survival among the elderly compared to younger patients. 2,3 There has been publications suggesting an inferior effect on intravesical instillation therapy in octogenarians.…”

Section: Introductionmentioning

confidence: 99%

Urothelial Carcinoma of the Bladder in Swedish Geriatric Patients: A Population-based Study

Thorstenson¹

2017

MOJGG

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Background: The aim of this study was to describe age at presentation, treatment and cancer-specific survival in patients with urinary bladder cancer (UBC) in a populationbased cohort, with special reference to patients 75years or older. Methods:All primary UBC patients with urothelial pathology reported to the Swedish National Registry of Urinary Bladder Cancer (SNRUBC) from 1997 to 2014 were included in the study. Groups were compared regarding age at diagnosis, primary treatment and survival.Results: A substantial proportion of the patients were diagnosed with UBC late in life; 10.7% of the men and 15.0% of the women were aged >85 ys at presentation. In the group of patients with T1 UBC, the patients aged 75ys or older were less often treated with intravesical installation therapy (p<0.001). The patients aged 75ys or older with T1 UBC had an inferior cancer-specific survival (p<0.001) compared to younger patients. Conclusion:In this population-based cohort comprising virtually all patients diagnosed with UBC in Sweden, age 75 ys or older is associated with an inferior proportion of patients who undergo intravesical instillation therapy. Age 75 ys or older is also associated with an inferior cancer-specific survival in urinary bladder cancer.

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Population Trends in Aging and Cancer

Lund

2017

Geriatric Oncology

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Several recent studies from Denmark have shown that age is the strongest risk factor for developing cancer. These reports gave an overview of the trends in cancer incidence, mortality, prevalence, and relative survival in Denmark from 1980 to 2012 focusing on age, comparing persons aged 70 years or more with those aged less than 70 years. Data was collected from the NORDCAN database with comparable data on cancer incidence, mortality, prevalence, and relative survival in the Nordic countries. The Danish data originate from the Danish Cancer Registry and the Danish Cause of Death Registry with follow-up for death or emigration until the end of 2013. The studies found a higher incidence and mortality rates of all sites, but nonmelanoma skin cancer, and that the relative survival was lower among persons aged 70 years or more than those aged less than 70 years. The age distribution remained constant over time while the percentage of persons dying from cancer decreased with time up to the age of 79 years but increased for those aged 80 years or more, in whom about a third of all cancer deaths occurred in 2012. There was an increase in the number of prevalent cancer

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Trends in cancer of the urinary bladder and urinary tract in elderly in Denmark, 2008–2012

Abstract: More prospective data are needed, preferably as randomized clinical trials, for determining the influence of age on the decisions of the surgical approach as well as chemo/radiotherapy for the elderly patients with urothelial cancers compared to younger patients.

Cited by 8 publications

References 26 publications

Living with Bladder Cancer: Self-reported Changes in Patients’ Functional and Overall Health Status Following Diagnosis

Living with Bladder Cancer: Self-reported Changes in Patients’ Functional and Overall Health Status Following Diagnosis

Urothelial Carcinoma of the Bladder in Swedish Geriatric Patients: A Population-based Study

Population Trends in Aging and Cancer

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