Trends in breast and cervical cancer in India under National Cancer Registry Programme: An Age-Period-Cohort analysis

Sathishkumar, Krishnan; Vinodh, N.; Badwe, Rajendra; Deo, S. V. S.; Manoharan, N; Malik, Reeni; Panse, NS; Ramesh, C.; Shrivastava, Abhishek; Swaminathan, Rajaraman; Vijay, C R; Narasimhan, Sandeep; Chaturvedi, Meesha; Mathur, Prashant

doi:10.1016/j.canep.2021.101982

Cited by 37 publications

(32 citation statements)

References 21 publications

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“…More than 1,500,000 Indian females are diagnosed with breast cancer every year [ 2 ]. In 2020, breast cancer contributed to 39.4% of total cancer found in India [ 3 ]. Globally, more than 2.3 million females are diagnosed with it and approximately 685,000 females die of it [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer

et al. 2022

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The solid self-nanoemulsifying drug delivery system (s-SNEDDS) is a growing platform for the delivery of drugs via oral route. In the present work, tamoxifen (TAM) was loaded in SNEDDS with resveratrol (RES), which is a potent chemotherapeutic, antioxidant, anti-inflammatory and P-gp inhibitor for enhancing bioavailability and to obtain synergistic anti-cancer effect against breast cancer. SNEDDS were developed using capmul MCM as oil, Tween 80 as surfactant and transcutol-HP as co-surfactant and optimized by central composite rotatable design. Neusilin US2 concentration was optimized for adsorption of liquid SNEDDS to prepare s-SNEDDS. The developed formulation was characterized and investigated for various in vitro and cell line comparative studies. Optimized TAM-RES-s-SNEDDS showed spherical droplets of a size less than 200 nm. In all in vitro studies, TAM-RES-s-SNEDDS showed significantly improved (p ˂ 0.05) release and permeation across the dialysis membrane and intestinal lumen. Moreover, TAM-RES-s-SNEDDS possessed significantly greater therapeutic efficacy (p < 0.05) and better internalization on the MCF-7 cell line as compared to the conventional formulation. Additionally, oral bioavailability of TAM from SNEDDS was 1.63 folds significantly higher (p < 0.05) than that of combination suspension and 4.16 folds significantly higher (p < 0.05) than TAM suspension. Thus, findings suggest that TAM- RES-s-SNEDDS can be the future delivery system that potentially delivers both drugs to cancer cells for better treatment.

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Section: Introductionmentioning

confidence: 99%

Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer

et al. 2022

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“…Cervical cancer incidence was higher among PBCRs in north eastern region of India. However, its incidence rate showed a decreasing trend among most of the PBCRs over time [17]. The study found that most of the cervical cancers were diagnosed at locally advanced stage.…”

Section: Discussionmentioning

confidence: 85%

Epidemiology of human papillomavirus related cancers in India: findings from the National Cancer Registry Programme

Ramamoorthy¹,

Sathishkumar²,

Das³

et al. 2022

ecancer

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Human papillomavirus (HPV) causes more than one-fourth of infection related cancers globally. The present study summarises the epidemiology of HPV related cancers in India, with a special focus on cervical and oropharyngeal cancer, utilising the National Cancer Registry Programme (NCRP) data. The data on HPV related cancer incidence and treatment were extracted from 28 population-based and 96 hospital-based cancer registries under the NCRP network. Incidence was presented as rates, clinical extent of disease and treatment provided as percentages. Joinpoint regression analysis was performed to calculate annual percent change in age adjusted incidence rates (AARs) over time. Incidence of HPV related cancers for 2025 was projected. Among all cancers, 7.5% were HPV related cancers. Cervical cancer (87.6%) and oropharyngeal cancer (63.2%) were the most common HPV related cancers in India among females and males, respectively. Cervical cancer was highest in Papumpare district (AAR: 27.7 per 100,000) and oropharyngeal cancer among males in East Khasi Hills district Population Based Cancer Registry (AAR: 11.4 per 100,000). In most PBCRS, cervical cancer incidence rate decreased significantly over the period of time. The majority of these cancers presented at locoregional spread stage of the disease and were treated with chemoradiation. The projected incidence of HPV related cancers is expected to increase to 121,302 by 2025. Implementation of effective prevention and control strategies like HPV vaccination and scaling up of screening could reduce the burden of HPV related cancers. Evidence from NCRP serves as the baseline to monitor the impact of HPV related policies and programmes in improving the outcome and prognosis.

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“…The Age-Period-Cohort (APC) model worldwide is used to study the time trend and projection of future burden of cancer incidence (Poirier et al, 2019;Smittenaar et al, 2016). There are few studies published in India using the APC model for assessing the temporal trend of various cancer sites (Sathishkumar et al, 2021;Malhotra et al, 2018), and one study used the APC model for projection (Malhotra et al, 2019). No study was found from India that projected cervical cancer using APC models and reports the net change according to decomposition analysis.…”

Section: Introductionmentioning

confidence: 99%

The Trend and Prediction of Cervical Cancer Incidence in Delhi, India: An Age-Period-Cohort Analysis

Malhotra

Manoharan²,

Deo³

2022

Asian Pac J Cancer Prev

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Trends in breast and cervical cancer in India under National Cancer Registry Programme: An Age-Period-Cohort analysis

Cited by 37 publications

References 21 publications

Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer

Solid Self-Nano Emulsifying Nanoplatform Loaded with Tamoxifen and Resveratrol for Treatment of Breast Cancer

Epidemiology of human papillomavirus related cancers in India: findings from the National Cancer Registry Programme

The Trend and Prediction of Cervical Cancer Incidence in Delhi, India: An Age-Period-Cohort Analysis

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