Trends in Asymptomatic Nasopharyngeal Colonization With Streptococcus pneumoniae After Introduction of the 13-valent Pneumococcal Conjugate Vaccine in Calgary, Canada

Ricketson, Leah J.; Wood, Melissa Lillian; Vanderkooi, Otto G; MacDonald, Judy; Martín, Irene; Demczuk, Walter; Kellner, James D.

doi:10.1097/inf.0000000000000267

Cited by 46 publications

(50 citation statements)

References 22 publications

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“…The Calgary Area Streptococcus pneumoniae Epidemiology Research (team has conducted 10-point prevalence surveys of pneumococcal NP colonization in healthy children o5 years of age attending Community Health Centres for routine immunization visits in Calgary, Canada since 2003 (Kellner et al, 2008;Ricketson et al, 2014). The study was approved by the University of Calgary Conjoint Health Research Ethics Board.…”

Section: Cohortmentioning

confidence: 99%

“…For the study herein, a subset of the swabs collected during a large point prevalence study of S. pneumoniae serotype carriage in the Calgary area (Ricketson et al, 2014) were used. A total of 51 healthy children, with a median age of 1.1 years, from those attending community health centers for routine immunization, along with 19 accompanying parents had nasopharyngeal (NP) and oropharyngeal (OP) swabs collected.…”

Section: Introductionmentioning

confidence: 99%

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Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age

et al. 2015

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The upper respiratory tract (URT) is a crucial site for host defense, as it is home to bacterial communities that both modulate host immune defense and serve as a reservoir of potential pathogens. Young children are at high risk of respiratory illness, yet the composition of their URT microbiota is not well understood. Microbial profiling of the respiratory tract has traditionally focused on culturing common respiratory pathogens, whereas recent culture-independent microbiome profiling can only report the relative abundance of bacterial populations. In the current study, we used both molecular profiling of the bacterial 16S rRNA gene and laboratory culture to examine the bacterial diversity from the oropharynx and nasopharynx of 51 healthy children with a median age of 1.1 years (range 1-4.5 years) along with 19 accompanying parents. The resulting profiles suggest that in young children the nasopharyngeal microbiota, much like the gastrointestinal tract microbiome, changes from an immature state, where it is colonized by a few dominant taxa, to a more diverse state as it matures to resemble the adult microbiota. Importantly, this difference in bacterial diversity between adults and children accompanies a change in bacterial load of three orders of magnitude. This indicates that the bacterial communities in the nasopharynx of young children have a fundamentally different structure from those in adults and suggests that maturation of this community occurs sometime during the first few years of life, a period that includes ages at which children are at the highest risk for respiratory disease.

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Section: Cohortmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Culture and molecular-based profiles show shifts in bacterial communities of the upper respiratory tract that occur with age

et al. 2015

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show abstract

“…En países con vacuna conjugada 13-valente, que incluye el serotipo 3, se ha visto una protección sub-óptima para este serotipo 10 . Estudios epidemiológicos realizados en algunos estados, como Calgary y Alaska 11,12 , que han incorporado esquema de vacunación con PCV-13, han demostrado una disminución en la portación nasofaríngea reduciendo de 19,9% a 13,3%. Respecto a los serotipos específicos, datos aportados por un estudio realizado en Milán 13 , demuestran que la reducción en la portación ha sido más significativa para el serotipo 19 A.…”

Section: Discussionunclassified

Meningitis neumocóccica por serotipo 19 A, de curso fatal: ¿Un caso prevenible?

Rivacoba

Cofré

Santolaya

2016

Rev. chil. infectol.

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“…Кроме того, выявился непрямой эффект массовой вакцинации, проявившийся в сниже-нии заболеваний у непривитых детей старшего возраста и взрослых за счет снижения носительства вакцин-ных серотипов пневмококков в популяции привитых [14][15][16]. Вакцинация повлияла также на снижение при-менения антибиотиков, что на сегодняшний день акту-ально в связи с ростом антибиотикорезистентности микроорганизмов [17].…”

Section: оригинальная статьяunclassified