Trends in antimicrobial resistance among bacteria causing septic arthritis in adults in a single center: A 15-years retrospective analysis

Ben‐Chetrit, Eli; Zamir, Amit; Natsheh, Ayman; Nesher, Gideon; Wiener-Well, Yonit; Breuer, Gabriel S.

doi:10.1007/s11739-019-02244-8

Cited by 7 publications

(6 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…8 The incidence of acute septic arthritis varies from 2 to 6 cases/ 100,000 people per year, with the highest incidence occurring in people with older than 55 years. 9 In our study, 40.57% MSKI patients met the diagnostic criteria, and MSKI patients with sepsis had a relatively higher rate of comorbidity with rheumatic diseases, diabetes, coronary heart disease, and deep vein thrombosis (DVT). Sepsis results from the host response to infection, and it was well known that rheumatic diseases and diabetes lead to an abnormal immune response including chronic inflammation or metabolic abnormalities, which further worsen the host response against infections.…”

Section: Dovepressmentioning

confidence: 71%

See 1 more Smart Citation

Clinical Features and Etiology of Musculoskeletal Infection with or without Sepsis in the Emergency Department

Zhang

Huang

et al. 2021

IJGM

View full text Add to dashboard Cite

Background: Musculoskeletal infection (MSKI) is a common reason to seek medical care in the emergency department (ED). We aimed to determine the clinical characteristics and etiology of patients with MSKI in our ED, the characteristics of MSKI with sepsis, and the predictors of death in sepsis patients. Methods: The study retrospectively analyzed patients with MSKI from April 1, 2017, to March 31, 2021. The patients were divided into non-sepsis and sepsis groups. Clinical data of these patients including their basic information, laboratory results, diagnostic results, and outcomes were collected. Statistical analysis was carried out using GraphPad Prism 5. Results: In all, 106 patients (70 male, 36 female) were enrolled in this study: 43 MSKI patients with sepsis and 63 MSKI patients without sepsis. Five patients with sepsis died. The patients' age and sex ratio were no significantly different between the sepsis and non-sepsis groups. In the sepsis group, the ratio of rheumatic diseases, diabetes, coronary heart disease, and deep vein thrombosis was significantly different than that in the non-sepsis group (all p<0.05). Fifty-six patients (54.37%) had positive etiology results. Staphylococcus, streptococcus, Klebsiella pneumoniae, Pseudomonas aeruginosa, and Escherichia coli were the most common bacteria found in both groups, but sepsis patients had more Candida albicans infections than non-sepsis patients (p=0.0331, p<0.05). The five patients who died in the sepsis group had higher serum levels of creatinine and procalcitonin (PCT). Multivariate logistic regression analyses showed that PCT (p=0.026; odds ratio, 1.038) was significantly related to mortality. Conclusion:In MSKI patients, rheumatic diseases, diabetes, coronary heart disease, and deep vein thrombosis are the risk factors for sepsis. Staphylococcus, streptococcus, K. pneumoniae, P. aeruginosa, and E. coli were the most common bacteria in MSKI patients, while MSKI patients with sepsis had more C. albicans infections. Elevated PCT was significantly related to death in sepsis patients.

show abstract

Section: Dovepressmentioning

confidence: 71%

“… 8 The incidence of acute septic arthritis varies from 2 to 6 cases/100,000 people per year, with the highest incidence occurring in people with older than 55 years. 9 …”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Etiology of Musculoskeletal Infection with or without Sepsis in the Emergency Department

Zhang

Huang

et al. 2021

IJGM

View full text Add to dashboard Cite

show abstract

“…[36][37][38]40 Second, the rising incidence of multidrug-resistant infections is increasingly documented globally as an emerging threat in both equine [61][62][63][64][65][66][67][68][69][70][71] and human clinical practice, with orthopaedic and joint surgery being affected similarly to other specialties. [72][73][74][75][76] These trends prompt re-evaluation of antibiotic protocols in general, including local injection or use in intra-synovial lavage, as inappropriate dosing may further induce greater development of resistance with potentially significant detrimental ramifications for both horses and staff in equine veterinary hospitals. 71 Multidrug-resistant bacterial isolates have been shown to be more frequently cultured from horses previously undergoing procedures or hospitalisation and those treated with antibiotics, although this trend has not been investigated specifically in relation to antibiotic use in joints.…”

Section: Ris K S and Con S Ider Ati On S With Intr A-arti Cul Ar Antib I Oti C Injec Tionsmentioning

confidence: 99%

“…However, an individualised therapeutic approach would consider trends and reported resistance patterns in pathogens most frequently encountered in different species affected by septic arthritis and antimicrobial susceptibilities to improve clinical outcomes through a multidisciplinary approach. 74 Staphylococcus and Streptococcus spp. are most commonly associated with septic arthritis in humans.…”

Section: Ris K S and Con S Ider Ati On S With Intr A-arti Cul Ar Antib I Oti C Injec Tionsmentioning

confidence: 99%

See 1 more Smart Citation

Intra‐articular administration of antibiotics in horses: Justifications, risks, reconsideration of use and outcomes

Pezzanite

Hendrickson

Dow

et al. 2021

Equine Veterinary Journal

View full text Add to dashboard Cite

Intra-articular (IA) antibiotics have been used by equine practitioners for decades when injecting joints in osteoarthritis or to treat septic arthritis. More recently, IA antibiotic usage has gained attention in human orthopaedic clinical practice with the goal of achieving high local drug concentrations in septic arthritis, particularly those associated with orthopaedic implants such as after arthroplasty. In horses, the inability to deliver antibiotics systemically for longer durations without risk of severe side effects (eg gastrointestinal and renal toxicity) has been the impetus to emphasise local vs systemic administration to treat joint infections. Furthermore, the development of biofilms or floating biofilm aggregates in synovial structures may require higher antibiotic doses to penetrate and therefore effectively treat the infection. Finally, antibiotics that would be prohibitively expensive at systemic doses may be administered intra-articularly based on sensitivity results. More rapid resolution of infection through a combination of antibiotic routes of administration (eg systemic, regional limb perfusion and intra-articularly) may also improve owner compliance and convenience in treatment, potentially decreasing cost and complications and improving prognosis with faster resolution of clinical signs compared with long-term administration of oral medications.However, as the IA route of administration is "off-label," appropriate doses have not been defined. Furthermore, the increasing

show abstract

Microbiology of Bone and Joint Infections

Chebbi,

Frigui,

Achour

2024

Histopathology of Bone and Joint Infections

View full text Add to dashboard Cite

Trends in antimicrobial resistance among bacteria causing septic arthritis in adults in a single center: A 15-years retrospective analysis

Cited by 7 publications

References 27 publications

Clinical Features and Etiology of Musculoskeletal Infection with or without Sepsis in the Emergency Department

Clinical Features and Etiology of Musculoskeletal Infection with or without Sepsis in the Emergency Department

Intra‐articular administration of antibiotics in horses: Justifications, risks, reconsideration of use and outcomes

Microbiology of Bone and Joint Infections

Contact Info

Product

Resources

About