Trends and Research Hotspots of Knockdown Resistance in the Aedes Genus in Indonesia: A Bibliometric Surveillance from the Scopus Database

Abstract

Introduction: Knockdown resistance in the Aedes genus in Indonesia is increasing; however, a comprehensive analysis of trends and research hotspots has not been reported.Objectives: This study aimed to analyze the trends and research hotspots of knockdown resistance in the Aedes genus in Indonesia using bibliometric surveillance, focusing on information from the Scopus database. Methods:Various keywords and databases were used to screen the articles, and all the articles obtained were analyzed using network, overlay, and density visualization using VOSviewer software version 1.6.20. Results:The findings showed that 14 articles were identified, resulting in 86 terms corresponding to the topic of this study, forming six main clusters of 1,496 links with 7,188 links. Aedes albopictus and Aedes aegypti have been reported to be resistant to the Aedes genus. The types of insecticides reported and suspected to cause kdr are pirimiphos methyl, cyfluthrin, piperonyl butoxide, cyhalothrin, cypermermethrin, transflutrin, temephos, malathion, organophosphates and fenitrothion. For the intended kdr target, alleles affected by these conditions occurred in f1534c, l982w, s989p, v1023g, s996p, and others. The region with the highest reported kdr in the genus Aedes was Yogyakarta (central Java), followed by Bali (Denpasar) and Jakarta. The identification of kdr in the Aedes genus in Indonesia has focused on 'voltage-gated sodium channel' OR 'vgsc,' 'larvae,' and 'temephos,' which are research hotspots that have a high linkage of terms with other terms, while the phrases 'voltage sensitive sodium channel' OR 'vssc,' 'primary vector' and 'genotyping' are research coldspots characterized by links dominated by recent research.Conclusions: There has been a significant increase in the incidence of kdr in the genus Aedes in Indonesia. This highlights the importance of focusing on understanding resistance mechanisms, exploring new control strategies, addressing geographic variation, and encouraging collaborative efforts to underscore the importance of a comprehensive approach to combating mosquito-borne diseases. This surveillance provides valuable insights for policymakers, researchers, and public health practitioners for formulating targeted interventions to mitigate the future impact of Aedes mosquito-borne diseases in Indonesia.

CRISPR-Cas9 Genome Editing Technology for Zoonotic Disease Control in Indonesia: A Comprehensive Review

“…Despite efforts to control zoonotic diseases through traditional methods, such as vector control, vaccination, and public health education, challenges remain [5,6]. The emergence of drug-resistant pathogens, the spread of zoonotic diseases across countries, and the complexity of disease transmission dynamics require innovative approaches for disease control [7][8][9].…”