Trends and Racial/Ethnic Disparities in Gluten-Sensitive Problems in the United States: Findings from the National Health and Nutrition Examination Surveys From 1988 to 2012

Choung, Rok Seon; Ditah, Ivo; Nadeau, Ashley; Rubio–Tapia, Alberto; Marietta, Eric; Brantner, Tricia L.; Camilleri, Michael; Rajkumar, S. Vincent; Landgren, Ola; Everhart, James E.; Murray, Joseph A.

doi:10.1038/ajg.2015.8

Cited by 104 publications

(87 citation statements)

References 31 publications

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“…Our results confirm previous studies by the observation that CDA is more common in Western than in non-Western populations 2 3 7 9 10. It needs to be considered though that we lacked data on intestinal biopsies, thereby impeding conclusions on final CD diagnosis.…”

Section: Discussionsupporting

confidence: 83%

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Ethnic differences in coeliac disease autoimmunity in childhood: the Generation R Study

et al. 2017

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Section: Discussionsupporting

confidence: 83%

“…SEP, parity (as indicator for siblings/family size), daycare and herpesvirus infections were suggested to be potential explanatory variables in the pathway between ethnic background and TG2A positivity 2–4 7 8 20. Information on household income33 and educational level,34 both indicators of SEP, was obtained from prenatal questionnaires.…”

Section: Methodsmentioning

confidence: 99%

Ethnic differences in coeliac disease autoimmunity in childhood: the Generation R Study

et al. 2017

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“…Medical disorders affecting the gastrointestinal tract (eg, rarely autoimmune atrophic gastritis, more frequently Helicobacter pylori gastritis and celiac sprue) impair iron absorption and lead to resistance to oral iron treatment. 16,17 In inflammatory bowel diseases iron deficiency may be due to both poor absorption and blood loss. A functional reduction of iron absorption secondary to high hepcidin and ferroportin degradation may occur in these disorders, as well as in any other chronic inflammatory conditions.…”

Section: Traditional and Emerging Causes Of Iron Deficiencymentioning

confidence: 99%

Iron deficiency: new insights into diagnosis and treatment

2015

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Iron deficiency and iron deficiency anemia are common conditions worldwide affecting especially children and young women. In developing countries, iron deficiency is caused by poor iron intake and/or parasitic infection, whereas vegetarian dietary choices, poor iron absorption, and chronic blood loss are common causes in high-income countries. Erythropoiesis stimulating agents can result in functional iron deficiency for erythropoiesis even when stores are iron-replete. Diagnosis of iron deficiency is straightforward, except when it occurs in the context of inflammatory disorders. Oral iron salts correct absolute iron deficiency in most patients, because low hepcidin levels facilitate iron absorption. Unfortunately frequent side effects limit oral iron efficacy. Intravenous iron is increasingly utilized, because currently available preparations allow rapid normalization of total body iron even with a single infusion and are effective also in functional iron deficiency and in iron deficiency associated with inflammatory disorders. The evidence is accumulating that these preparations are safe and effective. However, long-term safety issues of high doses of iron need to be further explored. Learning Objectives• To diagnose absolute iron deficiency, iron deficiency anemia, and functional iron deficiency in the light of recent advances in iron metabolism • To evaluate advantages and disadvantages of oral and intravenous iron therapy

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“…A patient's small-intestinal system produces mucosal antibodies (particularly IgA) to combat the gliadin subfraction of gluten when wheat-related gluten is ingested in the diet. These pathological immune reactions result in smallintestinal inflammation as well as mucosal breakthrough (11). CD may present with a range of symptoms and findings, including malnutrition, osteoporosis, irondeficiency anemia, and increased mortality (12,14).…”

Section: Discussionmentioning

confidence: 99%

Celiac disease prevalence in patients with hydatid cyst

Poyrazoglu¹,

Dönder²,

Dülger³

et al. 2017

J Turgut Ozal Med Cent

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Aim: Hydatid cyst (HC), which is localized in the liver and lungs in most cases, has been associated with a variety of hematologic and biochemical manifestations. Celiac disease (CD) is a small-intestinal malabsorption syndrome caused by hypersensitivity to gluten in subjects who carry the HLA haplotypes HLA DQ2 and DQ8. This study has attempted to show the connection between CD and HC. Material and Methods: We prospectively analyzed data from 211 HC patients, 62 of whom had extrahepatic involvement of HC; in addition, we also classified the patients' hydatid cysts by their radiologic features. All patients tested positive for HC by ELISA. Sera from the study population were also analyzed for IgA and IgG with ELISA using human recombinant tTG (AESKU. Diagnostics, Germany); the data were then analyzed statistically. Results: Twelve cases of seropositivity of TTG IgA were found among patients with HC. In the control group, the rate of TTG IgG seropositivity was only 2 out of 211 patients (~2%), which was lower than those with HC. In patients with HC, the mean WBC level was higher in patients with TTG IgA seropositivity compared with those without TTG IgA seropositivity. Younger ages were independently associated with TTG IgA seropositivity in the HC group. Conclusion: This study furthers the understanding of CD risk in HC. If confirmed by future studies, the study's data will assist in developing optimal strategies for the detection of CD in patients with HC. Understanding the infectious factors involved in CD is important for identifying new approaches to the early detection of CD.

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Trends and Racial/Ethnic Disparities in Gluten-Sensitive Problems in the United States: Findings from the National Health and Nutrition Examination Surveys From 1988 to 2012

Abstract: The overall prevalence of CD increased between 1988 and 2012 and is significantly more common in whites. In addition, a higher proportion of individuals maintaining a gluten-free diet in the absence of a diagnosis of CD are blacks.

Cited by 104 publications

References 31 publications

Ethnic differences in coeliac disease autoimmunity in childhood: the Generation R Study

Ethnic differences in coeliac disease autoimmunity in childhood: the Generation R Study

Iron deficiency: new insights into diagnosis and treatment

Celiac disease prevalence in patients with hydatid cyst

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