Trends and patterns of leprosy over a decade in a tertiary care hospital in Northern India: A retrospective analysis

Mushtaq, Sabha; Dogra, Naina; Dogra, Devraj; Faizi, Nafis

doi:10.4103/ijdvl.ijdvl_377_18

Cited by 11 publications

(19 citation statements)

References 7 publications

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“…[ 16 ] The higher male-to-female ratio in the present study is also similar to another study. [ 11 ] From the sulfone era, leprosy has been associated with male predisposition and this association was also seen in this study which might be attributed to greater mobility and increased accessibility to health care of male patients. Lepra reactions were seen in 10.71% patients with type 2 reaction being the only diagnosed in this study before initiation of treatment.…”

Section: Discussionsupporting

confidence: 64%

“…[ 10 ] A recent Indian study has showed overall smear positivity in 29.6% of leprosy cases with an increasing trend of smear positivity over the years. [ 11 ] Although AFB are better demonstrated in biopsies,[ 12 13 14 ] it is technically demanding, invasive, and has no definite role in the management of leprosy. Present study mainly emphasizes on the detection of AFB in slit skin smear from suspected cases of leprosy.…”

Section: Discussionmentioning

confidence: 99%

“…The majority of AFB-positive cases in this study belonged to middle age group (31–50 years), similar to finding showed by other studies. [ 11 15 ] The incidence of leprosy is said to increase between 10 and 20 years of age and peaks between 20 and 35 years of age. [ 16 ] The higher male-to-female ratio in the present study is also similar to another study.…”

Section: Discussionmentioning

confidence: 99%

“…Such demographic changes have been also showed by other study from different parts of India as well. [ 11 ] Only limited efforts have been made in India to include the numerous nonallopathic practitioners in control as well as elimination of leprosy, but their inclusion is important to its success. [ 19 ] Sustaining the gains made so far and further reducing the disease burden in India, an innovative, integrated approach that includes ongoing education, efforts to identify interventions which can reduce stigma are required and there is a need of inclusion of nonallopathic practitioners in disease control programs.…”

Section: Discussionmentioning

confidence: 99%

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Spectrum of leprosy among suspected cases attending a teaching hospital in Western Rajasthan, India

Kalita

Nag

Yedale

2020

J Family Med Prim Care

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Background: Leprosy is a chronic granulomatous infectious disease, which mainly involves skin, peripheral nerves, mucosa of the upper respiratory tract, and eyes. According to National Leprosy Eradication Programme 2017–18 annual report, the annual new case detection rate from Rajasthan is 1.27 per 1 lakh population and prevalence rate is 0.14. Aims and Objective: The main objective of this study was to determine the spectrum of Mycobacterium leprae infections among suspected cases attending a teaching hospital in western Rajasthan, India. Materials and Methods: This is a retrospective study conducted in the Department of Microbiology, in a teaching hospital, western Rajasthan, between the period of January 2017 and April 2019. The records of modified Ziehl–Neelsen staining during the study period were analyzed. The demographic data like age and sex along with clinical diagnosis were also recorded from laboratory register and hospital information system. Results: Out of total 91 suspected cases, 30.77% was microbiologically confirmed cases of leprosy. Out of total positive cases, 71.43% were male and 28.57% were female. A maximum number of positive (50%) were found in the age group of 31–50 years. Conclusion: Present study gives an insight about the spectrum of leprosy in the region. The large number of positive cases signifies that leprosy awareness and programs aimed at elimination need to be more vigorously implemented. To achieve complete eradication from this menace, newer strategies like effective vaccine development and drug-resistance testing should be implemented.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Spectrum of leprosy among suspected cases attending a teaching hospital in Western Rajasthan, India

Kalita

Nag

Yedale

2020

J Family Med Prim Care

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“…However, there is an increase trend of pediatric cases with grade 2 disability, polar lepromatous (LL), and other multibacillary cases. LL or subpolar lepromatous leprosy patients (BL) remain a challenge for specialists who accompany them in specialized care centers [4].…”

Section: Introductionmentioning

confidence: 99%

Daily Moxifloxacin, Clarithromycin, Minocycline, and Clofazimine in Nonresponsiveness Leprosy Cases to Recommended Treatment Regimen

Almeida¹,

Buarque²,

da³

2020

Int J Trop Dis

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Background: In hyperendemic countries for leprosy, there has been a growing increase in clinical multibacillary "nonresponsiveness" leprosy cases to the fixed-duration treatment recommended by World Health Organization (MDT-MB). There are no defined protocols to treat these patients. Methods: A retrospective, observational case series study was conducted of 4 patients with multibacillary leprosy who presented to a specialized Leprosy health care. Between July 1, 2018, and July 31, 2020, they were treated with moxifloxacin, clarithromycin, minocycline, and clofazimine. A literature review was conducted on the clinical features and treatment of nonresponsiveness leprosy cases to regular MDT-MB. Results: Four patients (3 male; mean [SD] age at treatment, 41 [22.6] years) with nonresponsiveness lepromatous leprosy to regular MDT-MB were successfully treated with daily moxifloxacin, clarithromycin, minocycline and clofazimine for 24 months. There were reduction in the number and size of skin lesions and infiltrations, neural thickening (both visually and by palpation), bacteriological index, and leprosy reactions at 6 to 24 months after initiation of therapy. Conclusions: This case series suggests that daily moxifloxacin, clarithromycin, minocycline and clofazimine association may hold promise as a treatment for refractory lepromatous leprosy to regular MDT-MB.

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Multiple Asymptomatic Nodules on the Body

Pradhan

Rout

2022

Clinical Cases in Dermatology

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Trends and patterns of leprosy over a decade in a tertiary care hospital in Northern India: A retrospective analysis

Cited by 11 publications

References 7 publications

Spectrum of leprosy among suspected cases attending a teaching hospital in Western Rajasthan, India

Spectrum of leprosy among suspected cases attending a teaching hospital in Western Rajasthan, India

Daily Moxifloxacin, Clarithromycin, Minocycline, and Clofazimine in Nonresponsiveness Leprosy Cases to Recommended Treatment Regimen

Multiple Asymptomatic Nodules on the Body

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