Trends and Disparities in Colonic Diverticular Disease Hospitalizations in Patients With Morbid Obesity: A Decade-Long Joinpoint Analysis

Abstract

We aimed to describe epidemiologic trends in outcomes of colonic diverticular disease (CDD) hospitalizations in morbidly obese patients. MethodsWe searched the United States National Inpatient Sample databases from 2010 through 2019, obtained the incidence rate of morbid obesity (MO) among CDD hospitalizations, and used Joinpoint analysis to obtain trends in these rates adjusted for age and sex. Hospitalizations involving patients less than 18 years of age were excluded. Trends in mortality rate, mean length of hospital stay (LOS), and mean total hospital charge were analyzed. Multivariate regression analysis was used to obtain trends in adjusted mortality, mean LOS, and mean total hospital charge. ResultsWe found an average annual percent change of 7.5% (CI = 5.5-9.4%, p < 0.01) in the adjusted incidence of MO among hospitalizations for CDD over the study period. We noted a 7.2% decline in mortality (p = 0.011) and a 0.1 days reduction in adjusted LOS (p < 0.001) over the study period. Hospitalizations among the middleaged and elderly had adjusted odds ratios of 7.18 (95% CI = 2.2-23.3, p = 0.001) and 24.8 (95% CI = 7.9-77.9, p < 0.001), respectively, for mortality compared to those in young adults. The mean LOS was 0.29 days higher in females compared to males (p < 0.001). ConclusionThe incidence of MO increased among CDD hospitalizations while mortality and mean LOS reduced over the study period. Outcomes were worse in older patients, with an increased mean LOS in females compared to males.

Association of Metabolic Syndrome Components and Colonic Diverticulosis in the Very Elderly: A Tertiary Health Network Study

“…Bae et al highlighted that MetS is strongly associated with asymptomatic CD risk, particularly in those with a larger waist circumference and BMI [27]. Ojemolon et al conducted a decade-long joinpoint analysis investigating the trends in hospitalizations for colonic diverticular disease in patients with morbid obesity and found that metabolic factors associated with morbid obesity may contribute to the development of CD and its related hospitalizations [28]. While these studies collectively provide insights into the possible link between MetS and CD, further investigation is warranted to fully elucidate the underlying mechanisms and establish the clinical implications of this relationship, particularly within the aging population.…”

Hospitalization Trends and Outcomes of Eosinophilic Esophagitis in the United States: A Decade-Long Nationwide Analysis

“…We assessed patient demographics and hospital-specific variables from the variables included in the NIS. We also assessed the comorbidity burden using Sundararajan's adaptation of the modified Deyo's Charlson comorbidity index (CCI), which has been used in prior Healthcare Cost and Utilization Project (HCUP) database research [6,7]. We highlighted the biodemographic trends over time for hospitalizations with EoE.…”