Trend research of vitamin D receptor: Bibliometric analysis

Abstract

Studies on vitamin D receptor (VDR) and its association with multiple disorders are expanding. This bibliometric study aims to find and summarize VDR-related publications, and compare them across various countries, organizations, and journals to demonstrate trends in VDR research. VOSviewer and Excel 2019 were used to classify and summarize Web of Science articles from 1900 to mid-2021. Total records of 8762 articles were analyzed, and maps of co-citations bibliometric keywords co-occurrence were designed. In conclusion, relative research interest and published papers related to VDR were growing in the past 30 years. The United States of America dominates the research regarding VDR. The highest quality of VDR research was achieved by the University of California System, University of Wisconsin System, and Harvard University. J Steroid Biochem Mol Biol, PLoS One, and J Biol Chem are the leading three productive journals on VDR. Various aspects of vitamin D deficiency associated disorders and genetic studies regarding VDR, including single nucleotide polymorphism, gene variants, epigenome, long non-coding ribonucleic acid (lncRNA), and small nucleolar RNA host gene 6 are potentially the recent research hotspot in this field. Moreover, coronavirus disease, polycystic ovary syndrome, non-alcoholic fatty liver disease, gut microbiota, gestational diabetes, systemic sclerosis, and chemoresistance are the trending medical conditions associated with VDR.

Visual analysis of the research trend and status on the association between vitamin D and immunity: From 2012 to 2021

“…Our results also suggested that VDR received long-standing attention in immune-related diseases (Figures 6, 7), which was consistent with another bibliometric study on VDR (42). As addressed in the previous section, VDR mediates much known physiological functions of the active form of vitamin D, 1,25(OH) 2 D. Upon binding to 1,25(OH) 2 D, VDR is heterodimerized with the retinoid X receptor in the nucleus, which then combines with the vitamin D-response element (VDRE) in the promoter of the target gene, thereby initiating gene transcription (7).…”

Telehealth and Artificial Intelligence Insights into Healthcare during the COVID-19 Pandemic

“…The bibliometric method was based on the Clarivate Analytics online subscription database Web of Science™ (WOS) to search the literature. WOS permits a comprehensive investigation of major fields or subfields, as previously reported [ 28 , 29 ]. In this study, we adjusted the document type to “article,” the language to “English,” and the period from 2019 to December 2021.…”

Vitamin D Supplementation for the Outcomes of Patients with Gestational Diabetes Mellitus and Neonates: A Meta-Analysis and Systematic Review

“…Vitamin D levels are negatively correlated with blood sugar, and they are positively associated with insulin resistance. Vitamin defciency in pregnant women with GDM increases the risk of insulin resistance and metabolic syndrome [57,58]. At present, an international consensus has not been reached on the dosage of VD supplementation during pregnancy.…”