Trend of tuberculosis case notification and treatment outcome in Lagos State, Nigeria: a 5-year retrospective study

Adejumo, Olusola Adedeji; Daniel, Olusoji; Abdur-Razzaq, Husseine A; Shogbamimu, Yeside; Femi-Adebayo, Toriola; Adepoju, Victor Abiola; Adebayo, Bisola; Sodipo, Oluwajimi Olanrewaju

doi:10.1093/trstmh/trx060

Cited by 13 publications

(9 citation statements)

References 18 publications

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“…Lagos State is the commercial nerve center of Nigeria, although it is the smallest state in the country in terms of land mass. The state hosts about 11.4% of the Nigerian population and is divided into 20 Local government areas (LGAs) and 37 local council development areas 15 . DOTS management of TB commenced in 2003 in collaboration with the WHO and the United States Agency for International Development (USAID) in Lagos State.…”

Section: Methodsmentioning

confidence: 99%

Factors influencing tuberculosis preventive practices among people living with HIV/AIDS enrolled in secondary health facilities in Lagos, Nigeria

Olakunle Olarewaju,

Oluyemisi Akande,

Abu

et al. 2023

Afr H. Sci.

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Background information: Tuberculosis is the most potent opportunistic infection leading to deaths among patients with Human Immunodeficiency Virus (HIV). Therefore, knowledge, attitude and practices regarding tuberculosis preventive strategy among People Living with HIV/AIDS (PLWHA) is vital in minimizing the risk of developing TB infection which forms the objective of this study. Methodology: A descriptive cross-sectional study carried out using multi-stage sampling technique in selecting 606 respondents. Data was collected using a semi-structured questionnaire and analysed with SPSS version 23. Result: Of all the respondents, 245 (40.4%) were within 28-37 years, 386 (63.7%) were females and 219 (36.1%) had secondary education. Majority of the respondents 500 (82.5%), 423(69.8%) and 411(67.8%) had positive attitude, good practices and good knowledge respectively. Associated factors were age, marital status, religion, educational status, knowledge and attitude with tuberculosis practices. Respondents between 18-27 years were twice less likely to engage in good TB preventive practices (OR- 0.44, 95% CI- 0.25-0.78, p = 0.004). Conclusion: Over half of respondents had good tuberculosis preventive practices, influenced by their socio-demographic characteristics, knowledge and attitude towards TB infection. Preventive efforts need to be strengthened among individuals between 18-27 years of age, non-Christians and those with lower educational status. Keywords: PLHIV; TB prevention; knowledge; attitude; practice.

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Section: Methodsmentioning

confidence: 99%

Factors influencing tuberculosis preventive practices among people living with HIV/AIDS enrolled in secondary health facilities in Lagos, Nigeria

Olakunle Olarewaju,

Oluyemisi Akande,

Abu

et al. 2023

Afr H. Sci.

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“…I will recommend based on the result of this study: [1]. Improvement of the diagnosis of childhood TB.…”

Section: Recommendationsmentioning

confidence: 96%

Risk Factors Associated with Tuberculosis and the Impact of the Introduction of Genexpert on the Diagnosis of Tuberculosis in Presumptive cases of a Hospital in Nigeria

Famuyiwa¹

2019

TIJPH

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Objective: To investigate the risk factors and impact of the introduction of XPERT MTB/RIF test on the diagnosis of pulmonary tuberculosis (TB) in presumptive cases in a General Hospital in Nigeria.Design and setting: A retrospective study that examines the record of the hospital, from January, 2015 to December, 2017. A logistic regression analysis was utilized to identify the associated factors.Results: There were total of 753 TB cases out of a total of 3639 people investigated. The rate of TB was 0.207. The multivariable regression analysis revealed that TB was significantly associated with all age groups: 15 -24 years [odds ratio (OR) = 5.316,[25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64].HIV positivity (OR = 0.519, (OR = 0.437,, were less likely to have TB.Conclusion: Age group 25-54 is an independent predictor of positive tuberculosis results in presumptive cases.

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“…The 16s rRNA gene of the 11 M. avium complex (MAC) was amplified from the DNA sample of each isolate by PCR using primers sp1 (5'-ACCTCCTTTCTAAGGAGCACC-3') and sp2 (5'-GATGCTCGCAACCACTATCCA-3') as previously reported [16,17] The sequencing reactions were performed in 3170 Applied Biosystem sequencer. These sequences were further compared with those deposited in GenBank, using the BLAST algorithm [18] Sequences that showed 98% identity at comparison were then considered as identified species as described in previous study [19].…”

Section: Sputum Culturementioning

confidence: 99%

Prevalence and Risk Factors for Pulmonary Mycobacteriosis in Lagos, Nigeria

Raheem

Iwalokun

Oluwadun

et al. 2019

AJMAH

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Background: Pulmonary mycobacteriosis has been documented in HIV-infected, diabetics, asthmatics, smokers and alcoholics and its progression and severity are affected by these risk factors. Inappropriate diagnosis of mycobacteriosis could lead to inappropriate treatment with anti- tuberculosis drugs. Methods: This cross-sectional, prospective study was conducted in patients with TB-like diseases attending six DOTs centres in Lagos, Nigeria, from May 2012 to October 2016. Participants’ informed consent was obtained, structured questionnaires administered to obtain socio-demographic and co-morbid data. Sputum samples collected and processed for microscopy and culture using Lowenstein-Jensen medium with or without pyruvate and MGIT 960 liquid medium. Mycobacteria were identified using MPT64 immunochromatographic, biochemical and molecular methods. This study investigated the presence and prevalence of mycobacteriosis in the participants and assessed the risk factors for the mycobacterial infections. Results: Of the 1,020 participants, 339 (33.2%) had mycobacteriosis of which 33 (9.7%) were caused by Non-Tuberculosis Mycobacteria (NTM) and 306 (90.3%) caused by Mycobacterium tuberculosis complex (MTBC). Of the isolated 306 MTBC, 247 (80.7%) were M. tuberculosis, 28 (9.2%) were M. africanum, 23 (7.5%) were M. bovis while 8(2.6%) were M. ulcerans [P < 0.0005]. The 33 NTM showed 11 (33.3%), 20 (60.6%) had HIV, 8(24.2%) M. fortuitum, 2 (6.1%) M. abscessus, 2 (6.1%) M. scrofulacium, 6 (18.2%) M. kansasii, 4 (12.1%) M. megateriense and 11 (33.3%) Mycobacterium avium complex (MAC). Sequence analysis of the 16s rRNA of the 11 MAC showed 3 (27.3%) M. avium, 5(45.5%) M. intracellulare, 2(18.2%) M. colombiense and 1(9.1%) M. velneri. M. fortuitum and MAC were significantly (P<0.05) associated with HIV infection, while only M. fortuitum relate strongly with diabetes (P <0.05). Conclusion: The study showed that mycobacteriosis is caused by different species of MTBC and NTM. Relatively high mycobacteriosis were detected during dry season and were significantly associated with gender, age, HIV and diabetes.

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Trend of tuberculosis case notification and treatment outcome in Lagos State, Nigeria: a 5-year retrospective study

Abstract: The CNR declined in Lagos State despite an increasing trend in DOTS and microscopy site expansions between 2013 and 2015. The LSTBLCPs need to re-engineer current strategies of active TB case findings in order to improve case notification in the state.

Cited by 13 publications

References 18 publications

Factors influencing tuberculosis preventive practices among people living with HIV/AIDS enrolled in secondary health facilities in Lagos, Nigeria

Factors influencing tuberculosis preventive practices among people living with HIV/AIDS enrolled in secondary health facilities in Lagos, Nigeria

Risk Factors Associated with Tuberculosis and the Impact of the Introduction of Genexpert on the Diagnosis of Tuberculosis in Presumptive cases of a Hospital in Nigeria

Prevalence and Risk Factors for Pulmonary Mycobacteriosis in Lagos, Nigeria

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