Trend of prevalence and incidence of systemic lupus erythematosus in South Korea, 2005 to 2015: a nationwide population-based study

Bae, Eun Hui; Lim, Sang Yeob; Han, Kyung Do; Jung, Jae-Hun; Choi, Hong Sang; Kim, Ha Yeon; Kim, Chang Seong; Kwon, Seong; Kim, Soo Wan

doi:10.3904/kjim.2018.303

Cited by 32 publications

(47 citation statements)

References 35 publications

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“…Although there was a slight bimodal pattern in incidence by age, the peak age of incidence in this study was between 25-39 years, with a lower incidence rate in the early (20-24 years) and late (40-44 years) childbearing age periods, suggesting that women are at risk of developing SLE during the period of time when they are most likely to have children (25-39 years). These results are consistent with previous Koreans studies that have reported a peak age of incidence in the 30-39 year age ranges [7,21]. The peak age of incidence for SLE in other countries varies: Taiwan and Spain have peak incidence at the age of 20-29, and in Norway, the peak incidence age is 16-29 [11,31,32].…”

Section: Discussionsupporting

confidence: 91%

“…A previous study reported a decrease in the incidence of SLE between 2005 and 2010 and then a slight annual increase until 2015 in Korea [7], but we observed a relatively constant rate of SLE incidence among Korean women of childbearing age. This suggests that the risk of developing SLE for the total population in a given year is affected by extrinsic factors including differences in environmental exposures such as an influenza epidemic, whereas the risk of developing SLE for the specific sociodemographic group of women of childbearing age is mainly affected by intrinsic factors such as age, gender, and female sex hormones [29,30].…”

Section: Discussioncontrasting

confidence: 74%

“…An average of 8.12 per 100,000 Korean women of childbearing age per year were at risk for developing SLE in this study. This average incidence was higher than the incidence reported previously in the total Korean population (3.72/100,000 person-years) and in Korean women of all ages (6.52/100,000 person-years), according to a study using information from the same database from the years 2005 to 2015 [7]. This suggests that women of childbearing age are a high-risk population for developing SLE.…”

Section: Discussioncontrasting

confidence: 59%

“…The worldwide incidence and prevalence of SLE vary greatly according to region and ethnicity, with an incidence range of 0.3 to 23.2 per 100,000 person-years and a prevalence range of 0 to 241 per 100,000 people [4][5][6][7][8][9]. Despite the high regional and ethnic variation, one common feature of SLE epidemiology is that the disease predominantly affects women during their childbearing years.…”

Section: Introductionmentioning

confidence: 99%

“…SLE occurs more often in women, with a female to male ratio of 9:1, and this ratio is higher (up to 15:1) during the reproductive years [10,11]. The peak incidence age for SLE in women is between the third and the fifth decades, during the peak reproductive years, whereas peak incidence for men is later (fifth to seventh decades) [7,9]. SLE is the second most common autoimmune disease following thyroid disease in women of childbearing age [12].…”

Section: Introductionmentioning

confidence: 99%

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Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Chung¹,

Park²,

Lim³

et al. 2020

Preprint

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Background Most women with systemic lupus erythematosus (SLE) are diagnosed with the disease in their reproductive years, but the incidence and prevalence of SLE among women of childbearing age have not been studied. The objective of this study was to estimate the incidence and prevalence of SLE among the Korean women of childbearing age. Methods Women aged 20 to 44 years with SLE were identified from National Health Insurance Service – National Health Information Database (2009–2016), which contain health information of approximately 97% of the Korean population. SLE was defined by International Classification of Diseases, 10th revision code, M32. Incidence and prevalence were calculated per 100,000 person-years and stratified by year and age. Results A total of 12,756 women with SLE were identified. The incidence of SLE from 2011 to 2016 among women in childbearing years was 8.18/100,000 person-years (95% CI 7.94–8.43), with the highest incidence in 2016 (8.56/100,000 person-years, 95% CI 7.95–9.17) and the lowest incidence in 2012 (7.85/100,000 person-years, 95% CI 7.28–8.42). The prevalence of SLE from 2009 to 2016 among women in childbearing years was 77.07/100,000 person-years (95% CI 75.76–78.39), with the highest prevalence in 2014 (79.47/100,000 person-years, 95% CI 77.64–81.30) and the lowest in 2010 (74.19/100,000 person-years, 95% CI 72.45–75.93). The peak age for SLE incidence was between 25–39 years, and lower incidence was seen in the early (20–24 years) and late (40–44 years) childbearing age periods. There was an increasing trend in prevalence according to age in women of childbearing age, with the highest prevalence occurring in the 40–44 age group. Conclusions The risk and burden of SLE are high among women during their childbearing years. This calls for special attention to this particular population group when allocating health resources.

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Section: Discussionsupporting

confidence: 91%

Section: Discussioncontrasting

confidence: 74%

Section: Discussioncontrasting

confidence: 59%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Chung¹,

Park²,

Lim³

et al. 2020

Preprint

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Declining Incidence of Systemic Lupus Erythematosus in Norway 1999–2017: Data From a Population Cohort Identified by International Classification of Diseases, 10th Revision Code and Verified by Classification

Haukeland,

Moe,

Brunborg

et al. 2024

Arthritis & Rheumatology

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ObjectiveTo provide complete, robust data on annual SLE incidence rates over nearly two decades from the Southeast Norway area (2.9 million inhabitants) and assess accuracy of SLE‐specific ICD codes for SLE diagnosis.MethodsFrom administrative databases, we identified all cases ICD‐10 coded as SLE during 1999‐2017 in Southeast Norway. We manually reviewed the chart of every case ICD‐10 coded as SLE to either confirm or reject SLE diagnosis. Using SLE classification criteria, we classified all cases with confirmed SLE. We estimated annual incidence rates of classified SLE, and subsets, defined by age at diagnosis, sex, and parental country of birth. Chi‐square test was applied for linear time‐trend analyses of incidence.ResultsAmong the 3488 cases ICD‐10 coded as SLE, chart‐reviews confirmed SLE diagnosis in 1558 (45%), of which 797 had new‐onset disease during 1999‐2017. Annual SLE incidence‐rates fell during 1999‐2017. The fall was most pronounced in female subjects aged 50‐59 years at diagnosis where incidence fell from 3.4 to 1.1 per 100 000 (p‐trend <0.001). Concurrent ecological data from the study area showed a 74% reduction in prescriptions of menopausal hormone treatment. Accuracy of ICD‐10 codes for incident SLE diagnosis was acceptable in juveniles and young adults (up to 20 years) but otherwise low.ConclusionIn a presumably complete population‐based cohort, we identified decreasing incidence of SLE, especially among female subjects aged 50‐59 years. While reasons for declining incidence are not clear, ecological data indicate a possible role of environmental factors, for example menopausal hormone treatments.image

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Epidemiology of SLE and related diseases

Ward

2021

Lahita's Systemic Lupus Erythematosus

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Trend of prevalence and incidence of systemic lupus erythematosus in South Korea, 2005 to 2015: a nationwide population-based study

Cited by 32 publications

References 35 publications

Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Incidence and prevalence of systemic lupus erythematosus among Korean women in childbearing years: a nationwide population-based study

Declining Incidence of Systemic Lupus Erythematosus in Norway 1999–2017: Data From a Population Cohort Identified by International Classification of Diseases, 10th Revision Code and Verified by Classification

Epidemiology of SLE and related diseases

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