Trend of morbidity and mortality of dengue in Tamil Nadu and Puducherry, South India

Sahanaa, Chandar; Mishra, Amit Kumar; Bazroy, Joy

doi:10.18203/2394-6040.ijcmph20175806

Cited by 5 publications

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References 7 publications

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“…Even this burden is a gross underestimate due to underreporting of cases and deaths, poor networking of healthcare facilities, and interstate/inter-regional differences in the availability of optimal healthcare 5 . The number of reported dengue cases in Pondicherry, South India had fallen from >3500 in 2012 to <500 in the year 2016, with a reported total mortality of just six cases during those five years 6 .…”

Section: Introductionmentioning

confidence: 99%

Quantum of fluids in hospitalised patients with dengue fever and the presence of warning signs: a pilot cross-sectional study

2019

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Background: The World Health Organization in 2009 revised categories of dengue fever severity into classes A, B, and C based on the presence or absence of warning signs. The quantum of oral and intravenous fluids (IVF) in hospitalised patients with Group B (warning signs) have, to our knowledge, not been studied. Oral fluids in hospitalised patients and monitoring administration with the help of patients’ relatives have not been assessed. Methods: Consecutive patients with dengue fever and warning signs were studied for 48 hours after hospitalisation. Patients were asked to consume 4-5 l of fluids. Maintenance and bolus IVF were administered depending upon the presence of compensated or hypotensive shock. Intake and urinary output were monitored by the patient’s attendant. Total fluids (oral and intravenous) were divided by a number of anthropometric measurements. Significance of compensated and hypotensive shock, thrombocytopenia and 20% change in haematocrit, bleeding episodes and the need for transfusions, and organ impairment were considered in relation to the total amount of fluids received daily. Results: In total, 41 patients were studied. Patients with obesity and hypotensive shock received significantly more fluids on Day 1; taller patients and those with tachycardia, higher haematocrit and elevated creatine kinase correspondingly received more on Day 2. Hypotensive shock was significantly correlated with fluids/BSA and fluids/weight, while laboratory parameters correlated most strongly with fluids/BMI. Conclusions: Most adults with dengue and warning signs seem to require >100 ml/kg/day of fluids during their stay. Advising a similar amount of fluids at home during epidemics may further reduce the need for admissions. Participation of patients and their relatives in the bedside management of fluid administration may go a long way in preventing morbidity and mortality. Adults probably need a better anthropometric measurement to decide on the quantum of fluids to be given.

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Section: Introductionmentioning

confidence: 99%

Quantum of fluids in hospitalised patients with dengue fever and the presence of warning signs: a pilot cross-sectional study

2019

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Nanotechnology-based antiviral therapeutics

Chakravarty

Vora

2020

Drug Deliv. and Transl. Res.

200

165

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The host immune system is highly compromised in case of viral infections and relapses are very common. The capacity of the virus to destroy the host cell by liberating its own DNA or RNA and replicating inside the host cell poses challenges in the development of antiviral therapeutics. In recent years, many new technologies have been explored for diagnosis, prevention, and treatment of viral infections. Nanotechnology has emerged as one of the most promising technologies on account of its ability to deal with viral diseases in an effective manner, addressing the limitations of traditional antiviral medicines. It has not only helped us to overcome problems related to solubility and toxicity of drugs, but also imparted unique properties to drugs, which in turn has increased their potency and selectivity toward viral cells against the host cells. The initial part of the paper focuses on some important proteins of influenza, Ebola, HIV, herpes, Zika, dengue, and corona virus and those of the host cells important for their entry and replication into the host cells. This is followed by different types of nanomaterials which have served as delivery vehicles for the antiviral drugs. It includes various lipid-based, polymer-based, lipid-polymer hybrid-based, carbon-based, inorganic metal-based, surface-modified, and stimuli-sensitive nanomaterials and their application in antiviral therapeutics. The authors also highlight newer promising treatment approaches like nanotraps, nanorobots, nanobubbles, nanofibers, nanodiamonds, nanovaccines, and mathematical modeling for the future. The paper has been updated with the recent developments in nanotechnology-based approaches in view of the ongoing pandemic of COVID-19.

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Quantum of fluids in hospitalised patients with dengue fever and the presence of warning signs: a pilot cross-sectional study

2019

View full text Add to dashboard Cite

Background: The World Health Organization in 2009 revised categories of dengue fever severity into classes A, B, and C based on the presence or absence of warning signs. The quantum of oral and intravenous fluids (IVF) in hospitalised patients with Group B (warning signs) has, to our knowledge, not been studied. Oral fluids in hospitalised patients and monitoring administration with the help of patients’ relatives have not been assessed. Methods: Consecutive patients with dengue fever and warning signs were studied for 48 hours after hospitalisation. Patients were asked to consume 4-5 l of fluids. Maintenance and bolus IVF were administered depending upon the presence of compensated or hypotensive shock. Intake and urinary output were monitored by the patient’s attendant. Total fluids (oral and intravenous) were divided by a number of anthropometric measurements. The significance of warning signs, compensated and hypotensive shock, thrombocytopenia, bleeding episodes and the need for transfusions, and organ impairment were considered in relation to the total amount of fluids received daily. Results: In total, 43 patients were studied. Patients with obesity and hypotensive shock received significantly more fluids on Day 1; taller patients and those with tachycardia, higher haematocrit and elevated creatine kinase correspondingly received more on Day 2. Hypotensive shock was significantly correlated with fluids/BSA, fluids/weight and fluids/BMI, while laboratory parameters correlated most strongly with fluids/BMI. Conclusions: Most adults with dengue and warning signs seem to require >100 ml/kg/day of fluids during their stay. Advising a similar amount of fluids at home during epidemics may further reduce the need for admissions. Participation of patients and their relatives in the bedside management of fluid administration may go a long way in preventing morbidity and mortality. Adults probably need a better anthropometric measurement to decide on the quantum of fluids to be given.

show abstract

Trend of morbidity and mortality of dengue in Tamil Nadu and Puducherry, South India

Cited by 5 publications

References 7 publications

Quantum of fluids in hospitalised patients with dengue fever and the presence of warning signs: a pilot cross-sectional study

Quantum of fluids in hospitalised patients with dengue fever and the presence of warning signs: a pilot cross-sectional study

Nanotechnology-based antiviral therapeutics

Quantum of fluids in hospitalised patients with dengue fever and the presence of warning signs: a pilot cross-sectional study

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